Links between Oropharyngeal Microbiota and IgA Nephropathy: A Paradigm Shift from isolated Microbe to Microbiome DOI

Narongsak Tangon,

Sirinart Kumfu, Nipon Chattipakorn

et al.

Microbiological Research, Journal Year: 2024, Volume and Issue: 292, P. 128005 - 128005

Published: Dec. 8, 2024

Language: Английский

The prevalence and characteristics of IgA antibodies to β2-spectrin and CBX3 in IgA nephropathy DOI Creative Commons

Ayako Koizumi,

Yoshihito Nihei, Kazuaki Mori

et al.

Kidney International Reports, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Carboxymethyl-lysine is a prominent target of circulating IgA in IgA Nephropathy DOI Creative Commons
Sara Alibrandi, Talita Ferreira Marques Aguiar,

Mattea Ausmeier

et al.

Kidney International Reports, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Pathogenesis of IgA nephropathy as a tissue-specific autoimmune disease DOI Creative Commons
Yoshihito Nihei, Daisuke Kitamura

International Immunology, Journal Year: 2024, Volume and Issue: unknown

Published: July 26, 2024

Abstract Glomerulonephritis (GN) is a group of heterogeneous immune-mediated kidney diseases that causes inflammation within the glomerulus. Autoantibodies (auto-Abs) are considered to be central effectors in pathogenesis several types GN. Immunoglobulin A nephropathy (IgAN) most common GN worldwide and characterized by deposition IgA glomerular mesangium kidneys, which thought mediated immune complexes containing non-specific IgA. However, we recently reported auto-Abs specific mesangial cells (anti-mesangium IgA) were found sera gddY mice, spontaneous IgAN model, patients with IgAN. We identified two autoantigens (β2-spectrin CBX3) selectively expressed on cell surface targeted anti-mesangial Our findings redefined as tissue-specific autoimmune disease. Regarding mechanisms production anti-mesangium IgA, studies using mice have revealed anti-CBX3 induced particular strains commensal bacteria oral cavity, possibly through their molecular mimicry CBX3. Here, discuss new concept from perspective this disease caused auto-Abs.

Language: Английский

Citations

1
IgA Nephropathy: Significance of IgA1-Containing Immune Complexes in Clinical Settings DOI Open Access
Hitoshi Suzuki, Jan Novák

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(15), P. 4495 - 4495

Published: Aug. 1, 2024

IgA nephropathy (IgAN) is considered to be an autoimmune disease characterized by the formation of IgA1-containing immune complexes in circulation and glomerular immunodeposits. Extensive research has identified multiple genetic, immunological, environmental factors contributing development progression. The pathogenesis IgAN a multifactorial process involving wherein aberrantly O-glycosylated IgA1 recognized as autoantigen. Consequently, clinical presentation highly variable, with wide spectrum manifestations ranging from isolated microscopic hematuria or episodic macroscopic nephrotic-range proteinuria. Whereas some patients may exhibit slowly progressive form IgAN, others present rapidly glomerulonephritis leading kidney failure. Development treatment for requires understanding characteristics pathogenic that enter mesangium induce injury. However, not all details mechanisms involved production galactose-deficient immune-complex are fully understood. Here, we review what have learned about nephritogenic half-century since first description 1968.

Language: Английский

Citations

1
IgA nephropathy ‘Treatment to Prevention’ DOI
Yusuke Suzuki

Nephrology, Journal Year: 2024, Volume and Issue: 29(S2), P. 47 - 50

Published: Sept. 1, 2024

Language: Английский

Citations

0
Lessons from IgA Nephropathy Models DOI Open Access

Toshiki Kano,

Hitoshi Suzuki, Yuko Makita

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11484 - 11484

Published: Oct. 25, 2024

IgA nephropathy (IgAN) is the most common type of primary glomerulonephritis worldwide; however, underlying mechanisms this disease are not fully understood. This review explores several animal models that provide insights into IgAN pathogenesis, emphasizing roles aberrant IgA1 glycosylation and immune complex formation. It discusses spontaneous, immunization, transgenic illustrating unique aspects development progression. The models, represented by grouped ddY (gddY) mouse, have provided guidance concerning multi-hit pathogenesis IgAN. In paradigm, genetic environmental factors, including dysregulation mucosal system, lead to increased levels aberrantly glycosylated IgA, nephritogenic formation, subsequent glomerular deposition, followed mesangial cell activation injury. Additionally, considers implications clinical trials targeting molecular pathways influenced (e.g., a proliferation-inducing ligand [APRIL]). Collectively, these expanded understanding while facilitating therapeutic strategies currently under investigation. Animal-model-based studies potential facilitate targeted therapies with reduced side effects for patients.

Language: Английский

Citations

0
Links between Oropharyngeal Microbiota and IgA Nephropathy: A Paradigm Shift from isolated Microbe to Microbiome DOI

Narongsak Tangon,

Sirinart Kumfu, Nipon Chattipakorn

et al.

Microbiological Research, Journal Year: 2024, Volume and Issue: 292, P. 128005 - 128005

Published: Dec. 8, 2024

Language: Английский

Citations

0