The impact of compression and confinement in tumor growth and progression: emerging concepts in cancer mechanobiology DOI Creative Commons

Allison McKenzie Johnson,

Charles Froman-Glover,

Akshitkumar M. Mistry

et al.

Frontiers in Materials, Journal Year: 2025, Volume and Issue: 12

Published: April 9, 2025

Cancer is one of the deadliest diseases despite aggressive therapeutics. This due in part to evolving tumor microenvironment (TME), which provide supportive cues that promote adaptation and progression. Emerging studies highlight significant role biophysical characteristics TME modulating all aspects cancer spread. With advance bioengineering platforms, deeper investigations into impact these features on progression are being conducted with a growing appreciation intratumoral compression underlie many changes. Intratumoral emerges early development increases magnitude as rapidly expands against itself its surrounding tissue. stress has effects both cells TME, including hypoxia, shear stress, extracellular matrix (ECM) remodeling, substrate stiffness. creates physically dense, pro-malignant environment can metastatic phenotypes spread but also present barriers for immune cell infiltration. review will analyze effect compressive cells, confined migration populations.

Language: Английский

Gene Expression Analysis of Autophagy Markers in Primary and Secondary Myelofibrosis DOI Open Access
Marin Međugorac,

Katarina Marija Glick,

Ana Livun

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2333 - 2333

Published: March 28, 2025

Background/Objectives: According to previous research, the process of autophagy in myeloid neoplasms has proven be ambivalent depending on type and stage disease. The aim our work was investigate mechanism patients with primary secondary myelofibrosis. Methods: Based RT-PCR method, we retrospectively analyzed expression Beclin-1 LC3B-II bone marrow cells myelofibrosis (74 participants) compared control group which had lymphoma a localized without infiltration (11 participants). Results: There no statistically significant difference between participants. Among myelofibrosis, higher significantly associated lower DIPSS. Higher better patient survival. Conclusions: Our results suggest that upregulation genes may favorable prognosis survival

Language: Английский

Citations

0
The impact of compression and confinement in tumor growth and progression: emerging concepts in cancer mechanobiology DOI Creative Commons

Allison McKenzie Johnson,

Charles Froman-Glover,

Akshitkumar M. Mistry

et al.

Frontiers in Materials, Journal Year: 2025, Volume and Issue: 12

Published: April 9, 2025

Cancer is one of the deadliest diseases despite aggressive therapeutics. This due in part to evolving tumor microenvironment (TME), which provide supportive cues that promote adaptation and progression. Emerging studies highlight significant role biophysical characteristics TME modulating all aspects cancer spread. With advance bioengineering platforms, deeper investigations into impact these features on progression are being conducted with a growing appreciation intratumoral compression underlie many changes. Intratumoral emerges early development increases magnitude as rapidly expands against itself its surrounding tissue. stress has effects both cells TME, including hypoxia, shear stress, extracellular matrix (ECM) remodeling, substrate stiffness. creates physically dense, pro-malignant environment can metastatic phenotypes spread but also present barriers for immune cell infiltration. review will analyze effect compressive cells, confined migration populations.

Language: Английский

Citations

0