Prolactin in sleep and EEG regulation: new mechanisms and sleep-related brain targets complement classical data

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 106000 - 106000

Published: Jan. 1, 2025

The role of prolactin in sleep regulation has been the subject extensive research over past 50 years, resulting identification multiple, disparate functions for hormone. Prolactin demonstrated a characteristic circadian release pattern with elevation during dark and diminution light. High levels were linked to non-rapid eye movement electroencephalogram delta activity humans. Conversely, hyperprolactinemia showed strong correlation REM rodent studies. may be implicated alterations female patterns observed reproductive cycle, it play enhancement following stress sleep-related immunological processes. In conclusion, appears have sleep-promoting role, particularly phase. However, does not appear central coherent regulation, as some neuropeptides such orexin. its principal function facilitate situational, yet adaptive, changes response challenging physiological phases, those associated stress, challenges, or cycle. Neuronal substrates prolactin-mediated effects remain unknown; however, recent studies provide insights into potential sites these effects.

Language: Английский

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The paraventricular nucleus of the hypothalamus: a key node in the control of behavioural states

The Journal of Physiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 22, 2025

Abstract The paraventricular nucleus (PVN) of the hypothalamus contains diverse populations neuropeptide‐producing neurons. These include neurons that synthesise oxytocin, vasopressin, corticotropin‐releasing hormone, thyrotropin‐releasing hormone and somatostatin. While it is well established these control secretion neuroendocrine hormones, there growing evidence they also expression important homeostatic behaviours. Here we review recent data showing a critical role PVN in controlling arousal, social behaviour, defensive behaviour pain. Collectively, this suggests key node wider neural network behavioural states. image

Language: Английский

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Lifelong Chronic Sleep Disruption in a Mouse Model of Traumatic Brain Injury

Neurotrauma Reports, Journal Year: 2024, Volume and Issue: 5(1), P. 61 - 73

Published: Jan. 1, 2024

Chronic sleep/wake disturbances (SWDs) are strongly associated with traumatic brain injury (TBI) in patients and being increasingly recognized. However, the underlying mechanisms largely understudied there is an urgent need for animal models of lifelong SWDs. The objective this study was to develop a chronic TBI rodent model investigate effect on behavior. We performed repetitive midline fluid percussion (rmFPI) 4-month-old mice monitored their behavior using non-invasive PiezoSleep system. Sleep/wake states were recorded before (baseline) then monthly thereafter. found that displayed significant decrease sleep duration both light dark phases, beginning at 3 months post-TBI continuing throughout study. Consistent phenotype, these showed circadian locomotor activity phenotypes exhibited reduced anxiety-like also gained less weight, had lean mass total body water content, compared sham controls. Further, extensive tissue loss increased glial fibrillary acidic protein ionized calcium-binding adaptor molecule 1 levels hypothalamus vicinity injury, indicative neuropathology. In summary, our identified critical time window pathology phenotypes. Future studies should leverage mouse molecular early life.

Language: Английский

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Sleep Disruption in a Mouse Model of Chronic Traumatic Brain Injury

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 14, 2023

Chronic sleep/wake disturbances are strongly associated with traumatic brain injury (TBI) in patients and being increasingly recognized. However, the underlying mechanisms largely understudied there is an urgent need for animal models of lifelong disturbances. The objective this study was to develop a chronic TBI rodent model investigate effect on behavior. We performed repetitive midline fluid percussion (rmFPI) four months old mice monitored their behavior using non-invasive PiezoSleep system. states were recorded before (baseline) then monthly thereafter. found that displayed significant decrease sleep duration both light dark phases, beginning at three post-TBI continuing throughout study. Consistent phenotype, these showed circadian locomotor activity phenotypes exhibited reduced anxiety-like also gained less weight, had lean mass total body water content, compared sham controls. Furthermore, extensive tissue loss increased GFAP IBA1 levels hypothalamus vicinity injury, indicative neuropathology. In summary, our identified critical time window pathology phenotypes. Future studies should leverage mouse molecular following early life.

Language: Английский

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New advances in molecular and neural mechanisms of sleep regulation

Brain Science Advances, Journal Year: 2022, Volume and Issue: 8(3), P. 163 - 164

Published: Sept. 1, 2022

Language: Английский

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