Acta Materia Medica,
Journal Year:
2025,
Volume and Issue:
4(2)
Published: Jan. 1, 2025
The
concept
of
food
and
medicine
homology
(FMH)
is
deeply
embedded
in
traditional
Chinese
carries
historical
importance.
recent
rigorous
definition
FMH
pertains
to
substances
that
exhibit
both
pharmacological
nutritional
functions,
have
active
ingredients
are
fundamentally
non-toxic
appropriate
for
extended
consumption.
With
the
progression
modern
biotechnology,
application
this
treating
diseases
has
markedly
expanded,
its
intrinsic
mechanisms
been
examined
detail.
use
cancer
therapy,
as
either
a
primary
treatment
or
an
adjuvant
paved
way
low-toxicity
treatments.
This
commentary
examines
theoretical
underpinnings,
potential
advantages,
practical
applications
prevention,
treatment,
support
enhancement.
Advantages
including
low
toxicity,
long-term
edibility,
minimal
adverse
effects,
high
patient
compliance
discussed.
Moreover,
owing
multicomponent
multitarget
characteristics,
may
provide
novel
opportunities
therapy.
Given
lethality
associated
ethical
implications,
current
research
should
prioritize
fundamental
studies
investigating
Concurrently,
preliminary
preclinical
would
be
establish
solid
foundation
subsequent
clinical
trials.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: Feb. 26, 2025
Emodin
has
shown
certain
anti-rheumatoid
arthritis
(RA)
activity
in
preliminary
studies.
However,
the
precise
mechanisms
of
emodin's
anti-RA
effects,
particularly
its
direct
targets,
remain
unclear.
This
study
aimed
to
evaluate
emodin
and
elucidate
potential
mechanisms,
with
a
specific
focus
on
identifying
molecular
targets.
Employing
collagen-induced
(CIA)
rat
model,
along
transcriptomic
analysis,
thermal
proteome
profiling
(TPP)
TNF-α-induced
L929
cell
was
confirmed,
TNF-α
as
target.
Techniques
such
drug
affinity
responsive
target
stability
(DARTS),
cellular
shift
assay
(CETSA),
Affinity
ultrafiltration-liquid
chromatography/mass
spectrometry
(AUF-LC/MS),
surface
plasmon
resonance
(SPR)
bio-layer
interferometry
(BLI)
validated
binding
TNF-α.
Molecular
dynamics
simulation,
ELISA
BLI
further
revealed
that
stabilizes
asymmetric
trimeric
structure
TNF-α,
disrupting
TNF-α-TNFR1
interaction.
In
vitro
assays,
including
luciferase
reporter
gene
MH7A
demonstrated
this
disruption
inhibits
NF-κB
activation,
leading
downregulation
inflammatory
mediators
IL-6,
IL-1β,
COX2.
conclusion,
directly
targets
stabilizing
blocking
interaction,
which
subsequently
suppresses
downstream
pathway
activation
contributes
potent
properties.
Foods,
Journal Year:
2025,
Volume and Issue:
14(1), P. 83 - 83
Published: Jan. 1, 2025
Chicken
with
Armillaria
mellea
prepared
via
pressure
cooking
is
a
traditional
Chinese
delicacy
great
potential
for
food
development.
Optimizing
its
time
crucial.
In
this
study,
chicken
and
were
pressure-cooked
different
amounts
of
(20
min,
25
30
35
40
min).
total,
101
81
volatile
compounds
identified
by
GC-MS
GC-IMS,
respectively.
The
results
showed
that
the
content
was
highest
at
min.
Nonanal,
decanal,
(E,E)-2,4-nonadienal,
(E,E)-2,4-decadienal,
1-octen-3-ol
as
most
critical
aroma
time,
which
brought
unique
fat,
oil,
mushroom
to
during
pressure-cooking
process.
optimal
determined
be
min
through
sensory
properties.
summary,
35–40
Our
research
not
only
preliminarily
conditions
industrial
processing
dish
cooking,
laying
foundation
later
production
dishes
international
sales,
but
also
stimulated
innovative
composite
development
promoted
people’s
exploration
mechanism
heat
treatment
on
flavor
taste.
Journal of Agricultural and Food Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 12, 2025
Under
the
guidance
of
a
bioactivity-guided
approach
and
HSQC
characteristic
signals,
nine
pairs
phthalic
dimers,
angesilides
A-I
(1-9),
with
complex
polycyclic
skeletons
featuring
bridged,
fused,
spiro
ring
systems
were
discovered
from
rhizomes
Angelica
sinensis.
Their
structures
absolute
configurations
established
by
comprehensive
spectroscopic
methods,
X-ray
diffraction
analysis,
chiral
separation.
Plausible
biosynthetic
pathway
for
1-9
was
proposed.
Moreover,
anti-inflammatory
activities
all
isolates
evaluated
in
lipopolysaccharide
(LPS)
stimulated
mouse
leukemia
cells
monocyte
macrophages
(RAW
=
264.7).
Among
them,
compound
9
showed
remarkable
inhibitory
activity
IC50
values
425
nM
could
significantly
decrease
IL-1β
IL-6
transcription
levels.
Interestingly,
(+)-9
has
superior
NO
compared
to
that
(-)-9,
which
verified
further
molecular
docking
analysis.
The
findings
provide
new
insights
into
A.
sinensis
as
functional
food
or
development
drug
candidates.
