Exploring the lipid-lowering effects of cinnamic acid and cinnamaldehyde from the perspective of gut microbiota and metabolites DOI
Xueke Wang, Tianxing Li, Ling Dong

et al.

Food & Function, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The increasing incidence and associated metabolic complications pose major challenges in the treatment of hyperlipidaemia. Cinnamon is a food medicinal resource with lipid metabolism, but mechanism by which its active components, cinnamic acid (CA) cinnamaldehyde (CM), alleviate hyperlipidaemia remains unclear. Biochemical, pathological, gut microbiota, metabolomic analyses were performed to investigate effects CA CM on HFD-fed mice underlying mechanisms involved. Supplementation reduced body weight, liver, adipose tissue accumulation HFD-induced mice; improved glucose metabolism; decreased inflammation oxidative stress levels, showing superior efficacy. Faecal microbiota transplantation confirmed that therapeutic effect was closely related core bacteria metabolites. Specifically, inhibited growth metabolism-related genera (e.g., Turicibacter Romboutsia) metabolites PC, LysoPCs, prostaglandin E2, arachidonic acid) while promoting beneficial Oscillospiraceae Colidextribacter) linoleic acid, phytosphingosine, stercobilin). Additionally, Spearman's correlation analysis revealed serum hepatic lipids, as well inflammatory factors, positively correlated Erysipelatoclostridium, Turicibacter, Eubacterium fissicatena, Enterorhabdus, cervonoyl ethanolamide, acetoxystachybotrydial acetate, whereas they negatively Lachnospiraceae NK4A136, stercobilin, LysoPE (15:0/0:0), phytosphingosine. In contrast, markers exhibited opposite pattern. conclusion, have potential regulate improve metabolism decrease levels.

Language: Английский

Comparative Genomics of Bifidobacterium animalis subsp. lactis Reveals Strain-Level Hyperdiversity, Carbohydrate Metabolism Adaptations, and CRISPR-Mediated Phage Immunity DOI Creative Commons
Özge Can, Ismail Gumustop,

Ibrahim Genel

et al.

Fermentation, Journal Year: 2025, Volume and Issue: 11(4), P. 179 - 179

Published: March 31, 2025

Several strains of Bifidobacterium animalis subsp. lactis are blockbusters commercial dietary supplement cocktails, widely recognized for their probiotic properties and found in various ecological niches. The present study aimed to perform an in-depth comparative genomic analysis on 71 B. isolated from diverse sources, including human animal feces, breast milk, fermented foods, supplements, better elucidate the strain level diversity biotechnological potential this species. average genome size was be 1.93 ± 0.05 Mb, with a GC content 60.45% 0.2, 1562 41.3 coding sequences (CDS), 53.4 1.6 tRNA genes. A revealed significant genetic among strains, core showing that 34.7% total genes were conserved, while pan-genome remained open, indicating ongoing gene acquisition. Functional annotation through EggNOG-Mapper CAZYme clustering highlighted metabolic capabilities, particularly carbohydrate metabolism. Nearly all (70 71) harbor CRISPR-Cas adaptive immune systems (predominantly Type I-E subtype), underscoring ubiquity phage defense mechanism spacer distinct strain-specific CRISPR profiles, certain sharing identical spacers correlate common phylogenetic clades or similar isolation sources—an indication exposure same populations shared selective pressures. These findings highlight dynamic co-evolution between its bacteriophages across niches point leveraging native future applications. Our enhance our understanding functional lactis, providing valuable insights use probiotics foods.

Language: Английский

Citations

0
Optimizing Cancer Treatment Through Gut Microbiome Modulation DOI Open Access

Kyuri Kim,

Mingyu Lee,

Yoojin Shin

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(7), P. 1252 - 1252

Published: April 7, 2025

The gut microbiome plays a pivotal role in modulating cancer therapies, including immunotherapy and chemotherapy. Emerging evidence demonstrates its influence on treatment efficacy, immune response, resistance mechanisms. Specific microbial taxa enhance checkpoint inhibitor while dysbiosis can contribute to adverse outcomes. Chemotherapy effectiveness is also influenced by composition, with engineered probiotics prebiotics offering promising strategies drug delivery reduce toxicity. Moreover, metabolites, such as short-chain fatty acids, systems have shown potential improve therapeutic responses. These findings underscore the importance of personalized microbiome-based approaches optimizing treatments.

Language: Английский

Citations

0
Polystyrene microplastics impair brown and beige adipocyte function via the gut microbiota-adipose tissue crosstalk in high-fat diet mice DOI
Guangning Kou, Yao Shuai, Amin Ullah

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138225 - 138225

Published: April 1, 2025

Language: Английский

Citations

0
Association of cardiovascular health with morbidity and mortality among U.S. adults with osteoarthritis: a population-based study DOI Creative Commons
Xuan Zhang, Haoxian Tang, Jingtao Huang

et al.

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 30, 2025

Language: Английский

Citations

0
Exploring the lipid-lowering effects of cinnamic acid and cinnamaldehyde from the perspective of gut microbiota and metabolites DOI
Xueke Wang, Tianxing Li, Ling Dong

et al.

Food & Function, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The increasing incidence and associated metabolic complications pose major challenges in the treatment of hyperlipidaemia. Cinnamon is a food medicinal resource with lipid metabolism, but mechanism by which its active components, cinnamic acid (CA) cinnamaldehyde (CM), alleviate hyperlipidaemia remains unclear. Biochemical, pathological, gut microbiota, metabolomic analyses were performed to investigate effects CA CM on HFD-fed mice underlying mechanisms involved. Supplementation reduced body weight, liver, adipose tissue accumulation HFD-induced mice; improved glucose metabolism; decreased inflammation oxidative stress levels, showing superior efficacy. Faecal microbiota transplantation confirmed that therapeutic effect was closely related core bacteria metabolites. Specifically, inhibited growth metabolism-related genera (e.g., Turicibacter Romboutsia) metabolites PC, LysoPCs, prostaglandin E2, arachidonic acid) while promoting beneficial Oscillospiraceae Colidextribacter) linoleic acid, phytosphingosine, stercobilin). Additionally, Spearman's correlation analysis revealed serum hepatic lipids, as well inflammatory factors, positively correlated Erysipelatoclostridium, Turicibacter, Eubacterium fissicatena, Enterorhabdus, cervonoyl ethanolamide, acetoxystachybotrydial acetate, whereas they negatively Lachnospiraceae NK4A136, stercobilin, LysoPE (15:0/0:0), phytosphingosine. In contrast, markers exhibited opposite pattern. conclusion, have potential regulate improve metabolism decrease levels.

Language: Английский

Citations

0