Oxalis pes-caprae L. Extract Conferred Its Biological Activities to Silver Nanoparticles DOI Creative Commons
Zahid Hussain Khan, Rahmat Ali Khan, Mushtaq Ahmed

et al.

Nano Biomedicine and Engineering, Journal Year: 2024, Volume and Issue: unknown

Published: March 7, 2024

This study used Oxalis pes-caprae L. (OP) to develop a low-budget, low-maintenance, and environment-friendly production method for silver nanoparticles (AgNPs) evaluated their antibacterial, antifungal, antioxidant abilities. Ultraviolet–visible (UV–Vis) spectroscopy results revealed maximum of absorbance at 431 nm, confirming the formation AgNPs. Moreover, Fourier transform infrared (FTIR) analysis synthesized AgNPs indicated presence various important functional groups, such as O–H, CH, H–C–H, C–O–C, which are involved in synthesis stability OP-AgNPs. X-ray diffraction (XRD) confirmed crystalline nature AgNPs, had an average particle size 46.31 nm four Bragg reflections 38.2°, 44.32°, 64.4°, 77.1°. The Nanomeasurer software that 89% particles 50 scanning electron microscope also spherical shaped, monodispersed, high-density formation. Energy dispersive was main element with highest sharp peak 3.0 keV. We assessed antibacterial antifungal activities OP extract on bacteria strains Escherichia coli, Acetobacter, Staphylococcus epidermidis, fungi Aspergillus nigar flavus. displayed more potent inhibition abilities than plant. Similarly, 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2-azobis,3-ethylbenzothiazoline-6-sulphonic acid (ABTS), hydrogen peroxide (H2O2) assays, better reduction capacities plant extract.

Language: Английский

Biopolymer based nanoparticles and their therapeutic potential in wound healing – A review DOI
Mohit Kumar, Syed Mahmood,

Shruti Chopra

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 267, P. 131335 - 131335

Published: April 10, 2024

Language: Английский

Citations

49
Fabrication of amino-capped Pluronic F127 with aldehyde dextran chains: A strategy improving extensibility, compressibility and self-healing hydrogel for wound healing DOI

Yutao Zheng,

Pengqi Guo,

Fengyuan Yong

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 304, P. 140774 - 140774

Published: Feb. 10, 2025

Language: Английский

Citations

1
Green methods for determination of paracetamol in drug samples: A comparative study DOI Creative Commons
Elham N. Mezaal, Kawther Ahmed Sadiq, Muntadhar M. Jabbar

et al.

Green Analytical Chemistry, Journal Year: 2024, Volume and Issue: 10, P. 100123 - 100123

Published: June 24, 2024

Non-steroidal anti-inflammatory drugs like paracetamol, which have strong antibacterial and analgesic properties, are frequently employed in medicine. On the other hand, fulminant liver necrosis adverse reactions can result from paracetamol exposure. The development of useful analytical techniques is therefore necessary to identify quantify paracetamol. Green determination been thoroughly studied last few years because their simplicity, increased sensitivity selectivity, cost-effectiveness. methods for quantification presence biological products has advanced, as this review details. advancement selective detection during past was studied. In particular, emphasis on inventive aspects brought about by spectrophotometry, chromatography, automated devices. There a lot reviews topic, but no one assessed greenness approaches samples. two scales were utilized calculating results. Analytical Greenness Calculator (AGREE) Complementary Procedure Index (ComplexGAPI) simple, free, sensitive programs.

Language: Английский

Citations

8
An Overview of The Green Synthesis of Coinage Metallic Nanoparticles: Protocols, Challenges, And Cancer Treatments DOI
Ebaa Adnan Azooz,

Nargis Amer Abduladheem,

Nidhal K. El Abbadi

et al.

Nano LIFE, Journal Year: 2024, Volume and Issue: 15(05)

Published: Nov. 9, 2024

Green nanomaterial synthesis is the process of producing various metallic nanoparticles (MNPs) utilizing bioactive reagents. It attempts to reduce waste and promote environmental sustainability by employing mild reaction conditions safe materials. Researchers have demonstrated a strong interest in using natural biomolecules extracted from plants synthesize MNPs. The individual this plant extract function as reducing, capping, stabilizing substances green production stable MNPs their related metal ion precursor solution. advantages method are that it environmentally friendly, does not require energy, cheap quick. Recently, been developed field cancer due qualities, including increased reactive surfaces small specified volume, which make them suited for traditional pharmaceuticals pharmaceutical compounds. MNPs, such gold (AuNPs), silver (AgNPs) copper (CuNPs), increasingly being used anticancer agents. This review describes three MNPs: AuNPs, AgNPs CuNPs extracts. most often synthetic NPs, accounting more than 25% all consumer items. generally employed antibacterial, antifungal antiviral purposes. Also, anti-cancer activities were explained. challenges predicted developments future studies addressed, critical real-world applications. In future, new types NPs will be generated modern technology, with wide range uses numerous industries.

Language: Английский

Citations

6
A hyaluronic acid-based dual-functional hydrogel microneedle system for sequential melanoma ablation and skin regeneration DOI

Zixuan Zhang,

Zhuo Zhang, Wen Zeng

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 138039 - 138039

Published: Nov. 1, 2024

Language: Английский

Citations

4
Plasma-Activated Water Improve Wound Healing in Diabetic Rats by Influencing the Inflammatory and Remodelling Phase DOI Open Access
Jovana Rajić, Nevena Grdović,

A. Markovic

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1265 - 1265

Published: Jan. 31, 2025

Diabetic foot ulcers have an enormous impact on patients’ quality of life and represent a major economic burden. The cause is delayed incomplete wound healing due to hyperglycemia, reduced blood flow, infections, oxidative stress chronic inflammation. Plasma-activated water (PAW) emerging as new therapeutic approach in treatment, it has many the advantages cold atmospheric plasma but easier apply, thus allowing for widespread use. aim this study was investigate potential PAW improve diabetic rats, with focus uncovering underlying mechanisms. Two full-thickness wounds control animals were treated PAW, monitored 15 days at five time points. improved rats mainly affected inflammatory phase healing. Application decreased number cells, myeloperoxidase (MPO) N-acetyl-b-D-glycosaminidase (NAG) activity, well mRNA expression proinflammatory genes rats. Ten after injury, treatment increased collagen deposition by almost 10% without affecting expression, correlation decrease Mmp-9/Timp-1 ratio. In conclusion, affects reducing response influencing extracellular matrix turnover, suggesting that great accelerate wounds.

Language: Английский

Citations

0
Biomineralized Nanocomposite‐Integrated Microneedle Patch for Combined Brachytherapy and Photothermal Therapy in Postoperative Melanoma Recurrence and Infectious Wound Healing DOI Creative Commons
Peng Liu, Hao Lü, Jessica C. Hsu

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Abstract In the surgical management of malignant melanoma, incomplete tumor resection and large‐area cutaneous defects are major contributors to high locoregional recurrence uncontrolled wound infections, resulting in poor prognosis prolonged recovery times for patients. Herein, a versatile nanocomposite microneedle patch (referred as GM‐Ag 2 S/Ca 32 P) is designed simultaneously eliminate residual post‐surgery promote healing infectious wounds. This effectively penetrates subcutaneous tissues, delivering therapeutic payloads infiltrating cells bacteria. The Ag P nanocomposites encapsulated within decompose acidic microenvironment tumors bacterial biofilms, releasing radioactive S nanodots, which enhance eradication bacteria killing through synergistic brachytherapy photothermal therapy (PTT). Moreover, promotes scar‐free by reducing inflammation, promoting granulation tissue formation, collagen deposition, angiogenesis, thanks localized hyperthermia, radiation, swelling biodegradation matrices. patch‐based postoperative adjuvant offers comprehensive strategy addressing melanoma healing, with promising potential clinical application postsurgical management.

Language: Английский

Citations

0
High-precision phenotyping of breast cancer exosomes based on washable magnetic microarrays and super-resolution tricolor fluorescence co-localization DOI

Jinxiu Wei,

Kai Zhu, Tingyu Wang

et al.

Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: 276, P. 117253 - 117253

Published: Feb. 12, 2025

Language: Английский

Citations

0
Apoptosis-inducing effects of aqueous extract of Eleutherococcus senticosus on non-small cell lung cancer cell proliferation DOI Creative Commons

Xiaolan Kou,

Yufeng Li, Lei Wang

et al.

CHINESE JOURNAL OF ANALYTICAL CHEMISTRY (CHINESE VERSION), Journal Year: 2025, Volume and Issue: unknown, P. 100510 - 100510

Published: Feb. 1, 2025

Language: Английский

Citations

0
In-Silico Analysis of Genetic Mutations in BRAF and PMS2 for Biomarker Discovery to Transform Colorectal Cancer Research DOI
Nusrat Jahan, Aziz Arshad, Sami Ullah

et al.

Indus journal of bioscience research., Journal Year: 2025, Volume and Issue: 3(2), P. 143 - 156

Published: Feb. 15, 2025

Point mutations in the PMS2 and BRAF genes have emerged as critical drivers of colorectal cancer, influencing key cellular processes such mismatch repair signal transduction. Understanding impact these at molecular level is essential for advancing cancer diagnostics therapies. This study leverages advanced bioinformatics tools to systematically identify evaluate potentially deleterious single nucleotide polymorphisms (SNPs) coding regions BRAF. Using SIFT, PolyPhen-2, I-Mutant 2.0, we assessed functional 2412 SNPs 453 From these, 32 one were predicted be highly deleterious, with significant implications protein stability function. Specifically, c.137G>T (p.Ser46Ile) c.383C>T (p.Ser128Leu) found disrupt structure, impairing its role repair. The mutation V600E was identified damaging, consistent previous studies that associate it oncogenic activation several cancers. These results highlight importance computational approaches predicting pathogenicity genetic their potential therapeutic targets cancer. establishes a foundation future experimental clinical research aimed evaluating targeting specific Computational analysis 21 BRAF, which may findings underscore significance progression targeted strategies.

Language: Английский

Citations

0