Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161104 - 161104
Published: Feb. 1, 2025
Language: Английский
Nano Biomedicine and Engineering, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
2
Materials Horizons, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
In this study, we reported a flower-like Cu 2 O@Ag SERS substrate for distinguish three types of cancer cells from white blood by using machine learning-assisted LDA, after separating samples via microfluidic chip.
Language: Английский
Citations
10
Small, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 7, 2025
Abstract Capturing circulating tumor cells (CTCs) in vivo from the bloodstream lessens metastasis and recurrence risks. However, absence of CTC receptors due to epithelial‐mesenchymal transition (EMT), limited binding capacity a single ligand, complexity blood flow environment significantly reduce efficiency capture vivo. Herein, multivalent ligand‐decorated microsphere enrichment system (MLMES) is crafted that incorporates column replete with an immunosorbent precisely recognizes binds stably expressed cluster differentiation 44 (CD44) glucose transporter protein 1 (GLUT1) present on exterior CTCs. As peripheral flows through column, CTCs are efficiently captured, achieving rate up 64.2%, highest reported date. Moreover, MLMES demonstrates excellent biocompatibility, broad‐spectrum capture, storage stability. Importantly, it eliminates substantial quantity blood, reducing risk metastasis. This breakthrough method has broad clinical application potential preventing recurrence, bringing new possibilities for improving cancer treatment.
Language: Английский
Citations
1
Biotechnology and Applied Biochemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 21, 2025
ABSTRACT As a significant cause of global mortality, the cancer has also economic impacts. In era therapy, mitigating side effects and costs overcoming drug resistance is crucial. Microbial species can grow inside tumor microenvironment inhibit growth through direct killing cells immunoregulatory effects. Although microbiota or their products have demonstrated anticancer effects, possibility acting as pathogens exerting in certain individuals risk. Hence, several genetically modified/engineered bacteria (GEB) been developed to this aim with ability diagnosing selective targeting destruction cancers. Additionally, GEB are expected be considerably more efficient, safer, permeable, less costly, invasive theranostic approaches compared wild types. Potential strains such Escherichia coli (Nissle 1917, MG1655), Salmonella typhimurium YB1 SL7207 ( aroA gene deletion), VNP20009 (∆msbB/∆purI) ΔppGpp (P Tet P BAD ), Listeria monocytogenes Lm at ‐LLO combat cells. When used tandem conventional treatments, substantially improve efficacy therapy outcomes. addition, public acceptance, optimal timing (s), duration dose identification, interactions other host cells, efficacy, safety quality, potential risks ethical dilemmas include major challenges.
Language: Английский
Citations
1
Nano Biomedicine and Engineering, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
1
Nano Biomedicine and Engineering, Journal Year: 2024, Volume and Issue: 16(3), P. 416 - 428
Published: July 4, 2024
Malignant tumors remain a serious threat to human health and life are major public problem globally. Herein, we designed synthesized novel nucleic acid nanomedicine AS1411-siRNA-LNPs (As@LNPs). Bmi-1 siRNA was coated with cationic liposomes, aptamer AS1411 tumor cell-targeting ability attached the outermost layer of liposomes. The average particle size As@LNPs 183 nm, polydispersion coefficient 0.187. encapsulation rate drug loading were 85% 4.6%, respectively. electron mobility 2.64 (μ/s)/(V/cm), zeta potential 33.79 ± 0.78 mV. microstructure evaluated via transmission microscopy. In vitro in vivo experiments showed that significantly inhibited growth promoted cell apoptosis. favorable biosafety tissues organs, except glomerulus renal epithelial cells.
Language: Английский
Citations
6
Nano Letters, Journal Year: 2024, Volume and Issue: 24(35), P. 11002 - 11011
Published: Aug. 21, 2024
Early stage hepatocellular carcinoma (HCC) presents a formidable challenge in clinical settings due to its asymptomatic progression and the limitations of current imaging techniques detecting micro-HCC lesions. Addressing this critical issue, we introduce novel ultrathin gadolinium-oxide (Gd-oxide) nanosheet-based platform with heightened sensitivity for high-field MRI as therapeutic agent HCC. Synthesized via digestive ripening process, these Gd-oxide nanosheets exhibit an exceptional acid-responsive profile. The integration polymer creates ultrasensitive probe, enabling visualization submillimeter-sized tumors superior sensitivity. Our research underscores probe's efficacy treatment orthotopic Notably, probe functions dually companion diagnostic tool, facilitating simultaneous therapy real-time monitoring capabilities. In conclusion, study showcases innovative tool that holds promise early detection effective micro-HCC.
Language: Английский
Citations
5
ACS Nano, Journal Year: 2024, Volume and Issue: 18(43), P. 30053 - 30068
Published: Oct. 16, 2024
The endoplasmic reticulum (ER) and mitochondria are essential organelles that play crucial roles in maintaining cellular homeostasis. simultaneous induction of ER stress mitochondrial dysfunction represents a promising yet challenging strategy for cancer treatment. Herein, hollow calcium–copper bimetallic nanoplatform is developed as cascade amplifier to reinforce breast For this purpose, we report facile method preparing CaCO3 (HCC) nanoparticles by regulating the dissolution–recrystallization process amorphous CaCO3, D@HCC-CuTH meticulously fabricated sequentially coating disulfiram-loaded HCC with copper coordination polymer hyaluronan. In tumor cells, dithiocarbamate–copper complex generated situ liberated disulfiram Cu2+ inhibits ubiquitin–proteasome system, causing irreversible intracellular Ca2+ redistribution. Meanwhile, induces via triggering self-amplifying loop burst, reactive oxygen species augment. Additionally, dihydrolipoamide S-acetyltransferase oligomerization mitochondria, further exacerbating damage cuproptosis. Collectively, amplification synergistically induce cuproptosis–paraptosis–apoptosis trimodal cell death pathway, which demonstrates significant efficacy suppressing growth. This study presents paradigm synchronously inducing subcellular organelle disorders boost multimodal therapy.
Language: Английский
Citations
5
ACS Nano, Journal Year: 2024, Volume and Issue: 18(44), P. 30345 - 30359
Published: Oct. 21, 2024
Lactate-enriched tumor microenvironment (TME) fosters an immunosuppressive milieu to hamper the functionality of tumor-associated macrophages (TAMs). However, tackling effects wrought by lactate accumulation is still a big challenge. Herein, we construct dual enzyme-driven cascade reaction platform (ILH) with TME modulation for photoacoustic (PA) imaging-guided catalytic therapy and immune activation. The ILH composed iridium (Ir) metallene nanozyme, oxidase (LOx), hyaluronic acid (HA). combination Ir nanozyme LOx can not only efficiently consume reverse into immunoreactive one promoting polarization TAMs from M2 M1 phenotype, thus enhancing antitumor defense, but also alleviate hypoxia as well induce strong oxidative stress, triggering immunogenic cell death (ICD) activating immunity. Furthermore, photothermal performance strengthen ability endow PA response. Based on changes in signals endogenous molecules, three-dimensional multispectral imaging was utilized track process vivo. This work provides nanoplatform activation regulating TME.
Language: Английский
Citations
5
Nano Biomedicine and Engineering, Journal Year: 2024, Volume and Issue: 16(3), P. 345 - 356
Published: Sept. 1, 2024
Language: Английский
Citations
5