Recent Progress in Electrochemical Biosensors Based on DNA-functionalized Nanomaterials

Nano Biomedicine and Engineering, Journal Year: 2024, Volume and Issue: 16(3), P. 309 - 330

Published: April 19, 2024

Electrochemical biosensors are characterized by rapid response, miniaturization, portability, and ease of operation. With tunable nanostructure, DNA has been comprehensively combined with electrochemical devices to design high-sensitivity selectivity for the achievement disease diagnosis, food safety, environmental monitoring. In recent years, DNA-functionalized have made significant research progress. this article, progress in vitro vivo diagnosis was reviewed. The structure sensing principles were first summarized. preparation based on nanomaterials introduced in detail. Meanwhile, latest evolution integrated portable For a further step, construction implantable real-time monitoring overviewed. Finally, challenges outlook discussed provide guideline future development biosensors.

Language: Английский

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Liposomes-enabled cancer chemoimmunotherapy

Biomaterials, Journal Year: 2024, Volume and Issue: 313, P. 122801 - 122801

Published: Sept. 3, 2024

Language: Английский

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Microfluidic-based electrically driven particle manipulation techniques for biomedical applications

RSC Advances, Journal Year: 2025, Volume and Issue: 15(1), P. 167 - 198

Published: Jan. 1, 2025

Microfluidic chips exhibit unique advantages in both economy and rapidity, particularly for the separation detection of biomolecules.

Language: Английский

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FAP-targeting biomimetic nanosystem to restore the activated cancer-associated fibroblasts to quiescent state for breast cancer radiotherapy

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 670, P. 125190 - 125190

Published: Jan. 7, 2025

Language: Английский

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A Dual‐Targeting Biomimetic Nanoplatform Integrates SDT/CDT/Gas Therapy to Boost Synergistic Ferroptosis for Orthotopic Hepatocellular Carcinoma Therapy

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Abstract The development of efficient therapeutic strategies to promote ferroptotic cell death offers significant potential for hepatocellular carcinoma (HCC) treatment. Herein, this study presents an HCC‐targeted nanoplatform that integrates bimetallic FeMoO 4 nanoparticles with CO‐releasing molecules, and further camouflaged SP94 peptide‐modified macrophage membrane enhanced ferroptosis‐driven multi‐modal therapy HCC. Leveraging the multi‐enzyme activities multivalent metallic elements, not only decomposes H 2 O generate oxygen alleviate tumor hypoxia but also depletes glutathione inactivate peroxides 4, which amplify sonodynamic under ultrasound (US) irradiation. Meanwhile, catalyzes Fenton reaction produce hydroxyl radicals chemodynamic therapy. Elevated intracellular reactive species trigger cascade release CO, leading lethal lipid peroxidation enhancing ferroptosis‐mediated This demonstrates robust anti‐tumor efficacy US irradiation favorable biosafety in both subcutaneous orthotopic HCC models, representing a promising approach Additionally, findings offer new insights into microenvironment modulation optimize US‐triggered cancer

Language: Английский

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Amorphous/Crystalline Urchin‐Like TiO₂ SERS Platform for Selective Recognition and Efficient Identification of Glutathione

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Glutathione serves as a common biomarkers in tumor diagnosis and treatment. The levels of its intracellular concentration permit detailed investigation the microenvironment. However, low polarization weak Raman scattering cross‐section make direct indirect detection challenging. This study designs an amorphous‐crystalline urchin‐like TiO 2 (AC‐UL‐TiO ) for accurate identification GSH GSSG. By synergistically regulating crystalline core amorphous shell, bandgap structure is optimized, thereby enhancing charge transfer efficiency. AC‐UL‐TiO demonstrates excellent SERS performance detecting dye molecules with good selectivity mixed analytes. enhancement factor (EF) R6G 6.89 × 10 6 , limit (LOD) −10 M. A SERS‐colorimetric dual‐modality platform developed based on @DTNB system to accurately monitor concentrations from 0 1000 µM, providing robust dual‐confirmation result. Importantly, combined principal component analysis method, can directly distinguish GSSG molecules. Besides, LOD are −8 M, which 100 times higher than that detection. These findings indicate holds potential trace microenvironments.

Language: Английский

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Nanobiomaterials Based Sonodynamic Therapy for Treament of Helicobacter pylori Infections: A Review

Nano Biomedicine and Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Advances in SERS detection method combined with microfluidic technology for bio-analytical applications

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: unknown, P. 125797 - 125797

Published: Jan. 1, 2025

Language: Английский

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Preparation of multifunctional theranostic nanoplatform SA-PB by in-situ polymerization

Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 138143 - 138143

Published: Jan. 1, 2025

Language: Английский

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An antigen-capturing and lymph node-targeting nanoparticle for cancer immunotherapy

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 993 - 1005

Published: Feb. 1, 2025

Language: Английский

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