Cell Level- Modeling of Aging and Rejuvenation DOI Open Access
Andrey Koptyug,

Yurij Sukhovei,

Е. Г. Костоломова

et al.

OBM Geriatrics, Journal Year: 2023, Volume and Issue: 07(04), P. 1 - 30

Published: Dec. 22, 2023

Understanding processes related to human aging and rejuvenation relies on experimental data advanced models operating at different levels. There are several existing conceptual specific modeling approaches. However, one of the tasks is compiling generic linking properties cell cell-element levels systemic - tissue, organ, whole body. One critical issues in relevant enormity interacting components sub-cell needed represent high-level systems properly. This paper describes a promising approach simulation population level for studying rejuvenation. It also presents initial conclusions formulated based results experiments coupled it. The model concepts proliferation niche homeostatic number stabilization through associated action apoptosis. Importantly, we address issue defining “aging” “rejuvenation” populations containing large numbers cells ages. possible demonstrate that regulation can be performed by maintaining concentration single regulatory substance. Predictions simulations proposed compared from publications specifically conducted validate model. Currently, none available contradicts detail. an inadequate elements employed statistical further limit progress such modeling. Expanding method include realistic features representing tissues, organs, body allow proper requires more techniques.

Language: Английский

"Possible Existence of the Relict Mechanism of Cell Protection During Division" DOI Open Access
Andrey Koptyug

Biomedical Journal of Scientific & Technical Research, Journal Year: 2023, Volume and Issue: 51(3)

Published: July 12, 2023

Antibacterial properties of the stem cells and human- plant- derived microvesicles are attracting increasing attention research community. Awareness publications pointing out to pronounced anti-bacterial isolated from supernatants different human origin prompted us test corresponding supernatant using simplified protocol. Extensive with more than 100 laboratory strains hospital isolates Gram-positive Gram- negative bacteria point a activity cultures actively dividing cells.

Language: Английский

Citations

2
Cell Level- Modeling of Aging and Rejuvenation DOI Open Access
Andrey Koptyug,

Yurij Sukhovei,

Е. Г. Костоломова

et al.

OBM Geriatrics, Journal Year: 2023, Volume and Issue: 07(04), P. 1 - 30

Published: Dec. 22, 2023

Understanding processes related to human aging and rejuvenation relies on experimental data advanced models operating at different levels. There are several existing conceptual specific modeling approaches. However, one of the tasks is compiling generic linking properties cell cell-element levels systemic - tissue, organ, whole body. One critical issues in relevant enormity interacting components sub-cell needed represent high-level systems properly. This paper describes a promising approach simulation population level for studying rejuvenation. It also presents initial conclusions formulated based results experiments coupled it. The model concepts proliferation niche homeostatic number stabilization through associated action apoptosis. Importantly, we address issue defining “aging” “rejuvenation” populations containing large numbers cells ages. possible demonstrate that regulation can be performed by maintaining concentration single regulatory substance. Predictions simulations proposed compared from publications specifically conducted validate model. Currently, none available contradicts detail. an inadequate elements employed statistical further limit progress such modeling. Expanding method include realistic features representing tissues, organs, body allow proper requires more techniques.

Language: Английский

Citations

0