Nano-based formulations of thymoquinone are new approaches for psoriasis treatment: a literature review
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Aug. 12, 2024
Psoriasis,
a
persistent
immune-mediated
inflammatory
skin
condition,
affects
approximately
2-3%
of
the
global
population.
Current
treatments
for
psoriasis
are
fraught
with
limitations,
including
adverse
effects,
high
costs,
and
diminishing
efficacy
over
time.
Thymoquinone
(TQ),
derived
from
Nigella
sativa
seeds,
exhibits
promising
anti-inflammatory,
antioxidant,
immunomodulatory
properties
that
could
prove
beneficial
in
managing
psoriasis.
However,
TQ’s
hydrophobic
nature
poor
bioavailability
have
hindered
its
usefulness
as
therapeutic
agent.
Recent
research
has
strategically
addressed
these
challenges
by
developing
nano-thymoquinone
(nano-TQ)
formulations
to
enhance
delivery
treating
Preclinical
studies
employing
mouse
models
demonstrated
nano-TQ
effectively
mitigates
inflammation,
erythema,
scaling,
epidermal
thickness,
cytokine
levels
psoriatic
lesions.
Various
formulations,
nanoemulsions,
lipid
vesicles,
nanostructured
carriers,
ethosomes,
been
explored
improve
solubility,
facilitate
penetration,
ensure
sustained
release,
achieve
site-specific
targeting.
Although
clinical
trials
currently
scarce,
outcomes
vitro
animal
promising.
The
potential
co-delivery
other
anti-psoriatic
agents
also
presents
avenues
further
investigation.
Language: Английский
"The Benefits of Nigella sativa for Skin Diseases and Heal Skin Injuries: An Overview of Phytochemicals and Pharmacological Properties"
Biomedical Journal of Scientific & Technical Research,
Journal Year:
2023,
Volume and Issue:
54(1)
Published: Dec. 13, 2023
Nigella
sativa
(N.
sativa)
is
a
medicinal
plant
with
long
history
of
use
in
various
traditional
systems
medicine,
such
as
Arab
and
Islamic
Unani,
Ayurveda,
Chinese
medicine.
N.
has
many
active
compounds,
alkaloids,
saponins,
thymoquinone,
that
give
it
wide
range
health
benefits.
It
can
act
diuretic,
bronchodilator,
antihypertensive,
antidiabetic,
analgesic.
Moreover,
antimicrobial,
anti-inflammatory,
antineoplastic
properties,
which
make
promising
natural
treatment
for
skin
conditions.
Language: Английский