Molecular Medicine,
Journal Year:
2023,
Volume and Issue:
29(1)
Published: July 5, 2023
Abstract
Abnormal
microbial
colonization
in
the
gut
at
an
early
stage
of
life
affects
growth,
development,
and
health,
resulting
short-
long-term
adverse
effects.
Microbial
patterns
preterm
infants
differ
from
those
full-term
that
babies
their
mothers
have
more
complicated
prenatal
postnatal
medical
conditions.
Maternal
complications,
antibiotic
exposure,
delivery
mode,
feeding
type,
use
probiotics
may
significantly
shape
microbiota
life;
however,
these
influences
subside
with
age.
Although
some
factors
processes
are
difficult
to
intervene
or
avoid,
understanding
potential
determinants
will
help
developing
timely
strategies
for
a
healthy
infants.
This
review
discusses
underlying
mechanisms.
EFSA Journal,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Jan. 1, 2025
Abstract
The
qualified
presumption
of
safety
(QPS)
process
was
developed
to
provide
a
assessment
approach
for
microorganisms
intended
use
in
food
or
feed
chains.
In
the
period
covered
by
this
Statement,
no
new
information
found
that
would
change
status
previously
recommended
QPS
taxonomic
units
(TUs).
TUs
list
were
updated
based
on
verification,
against
their
respective
authoritative
databases,
correctness
names
and
completeness
synonyms.
Of
54
notified
EFSA
between
April
September
2024
(33
as
additives,
17
enzymes
4
novel
foods),
50
not
evaluated
because:
12
filamentous
fungi,
1
Enterococcus
faecium
8
Escherichia
coli
(all
excluded
from
evaluation),
29
already
have
status.
One
notification
(Ensifer
adhaerens)
previous
Panel
Statement.
Another
(Enterococcus
lactis)
3‐year
cycle
reassessed
within
document.
Two
first
time
assessed
possible
status:
Serratia
plymuthica
Lacticaseibacillus
huelsenbergensis.
Bacillus
thuringiensis
nakamurai
been
response
internal
requests.
following
concluded
five
TUs.
L.
huelsenbergensis
can
be
granted
its
close
relatedness
several
other
species.
E.
lactis
is
due
insufficient
safety.
S.
B.
are
concerns.
cannot
lack
body
knowledge
chain.
EFSA Journal,
Journal Year:
2025,
Volume and Issue:
23(2)
Published: Feb. 1, 2025
Abstract
The
food
enzyme
bacillolysin
(EC
3.4.24.28)
is
produced
with
the
genetically
modified
Bacillus
amyloliquefaciens
strain
NPR
by
DSM
Food
Specialties
B.V.
production
meets
requirements
for
qualified
presumption
of
safety
(QPS)
status.
genetic
modifications
do
not
give
rise
to
concerns.
was
considered
free
from
viable
cells
organism
and
its
DNA.
intended
be
used
in
10
manufacturing
processes.
Since
residual
amounts
enzyme‐total
organic
solids
(TOS)
are
removed
one
process,
dietary
exposure
calculated
only
remaining
nine
It
estimated
up
6.450
mg
TOS/kg
body
weight
per
day
European
populations.
Given
QPS
status
absence
concerns
resulting
toxicity
tests
were
unnecessary
Panel.
A
search
homology
amino
acid
sequence
known
allergens
made
no
match
found.
Panel
that
risk
allergic
reactions
upon
cannot
excluded,
but
likelihood
low.
Based
on
data
provided,
concluded
this
does
concerns,
under
conditions
use.
EFSA Journal,
Journal Year:
2025,
Volume and Issue:
23(3)
Published: March 1, 2025
Abstract
The
food
enzyme
aqualysin
1
(EC
3.4.21.111)
is
produced
with
the
genetically
modified
Bacillus
subtilis
strain
LMG
S‐25520
by
Puratos
N.V.
In
a
previous
evaluation,
Panel
could
not
exclude
safety
concerns
due
to
an
insufficient
margin
of
exposure
and
noted
presence
recombinant
DNA
in
all
batches
tested.
As
follow‐up,
applicant
changed
manufacturing
process
provided
new
data.
These
data
established
that
production
meets
requirements
for
qualified
presumption
(QPS)
status,
no
arose
from
process;
hence,
toxicological
tests
were
considered
necessary.
free
viable
cells
organism
its
DNA.
It
intended
be
used
baking
processes.
Dietary
estimated
up
0.385
mg
TOS/kg
body
weight
per
day
European
populations.
A
search
homology
amino
acid
sequence
known
allergens
was
made,
matches
one
allergen,
20
respiratory
three
contact
found.
Based
on
provided,
concluded
risk
allergic
reactions
upon
dietary
cannot
excluded.
does
give
rise
under
conditions
use.
