Guidance for establishing and applying tolerable upper intake levels for vitamins and essential minerals DOI Creative Commons
Dominique Turck, Torsten Bohn,

Montaña Cámara

et al.

EFSA Journal, Journal Year: 2024, Volume and Issue: 22(11)

Published: Nov. 1, 2024

Abstract Vitamins and essential minerals are micronutrients that required for the normal functioning of human body. However, they may lead to adverse health effects if consumed in excess. A tolerable upper intake level (UL) is a science‐based reference value supports policy‐makers other relevant actors managing risks excess nutrient intake. EFSA's principles establishing ULs vitamins were originally developed by Scientific Committee on Food 2000. This guidance from EFSA Panel Nutrition, Novel Foods Allergens provides an updated framework UL assessments. draft was published 2022 underwent 2‐year piloting period. The present document incorporates revisions based experience gained through its practical implementation. It covers aspects related planning risk assessment (problem formulation definition methods) implementation (evidence retrieval, appraisal, synthesis, integration, uncertainty analysis). As previous framework, general chemicals food applied, i.e. hazard identification, characterisation, assessment, characterisation. Specific nutrients their biochemical physiological roles specific selective mechanisms maintain systemic homeostasis accumulation Such considerations must also be taken into account when conducting assessments nutrients.

Language: Английский

Scientific opinion on the tolerable upper intake level for vitamin D, including the derivation of a conversion factor for calcidiol monohydrate DOI Creative Commons
Dominique Turck, Torsten Bohn,

Jacqueline Castenmiller

et al.

EFSA Journal, Journal Year: 2023, Volume and Issue: 21(8)

Published: Aug. 1, 2023

Following two requests from the European Commission (EC), EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver a scientific opinion revision of tolerable upper intake level (UL) for vitamin D propose conversion factor (CF) calcidiol monohydrate into

Language: Английский

Citations

37
A view on vitamin D: a pleiotropic factor? DOI
Andrea Giustina, Marise Lazaretti‐Castro, Adrian R. Martineau

et al.

Nature Reviews Endocrinology, Journal Year: 2024, Volume and Issue: 20(4), P. 202 - 208

Published: Jan. 22, 2024

Language: Английский

Citations

16
Vitamin D and Cardiovascular Diseases: From Physiology to Pathophysiology and Outcomes DOI Creative Commons
Matteo Nardin, Monica Verdoia, Simone Nardin

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(4), P. 768 - 768

Published: March 30, 2024

Vitamin D is rightly recognized as an essential key factor in the regulation of calcium and phosphate homeostasis, affecting primary adequate bone mineralization. In last decades, a more complex wider role vitamin has been postulated demonstrated. Cardiovascular diseases have found to be strongly related levels, especially its deficiency. Pre-clinical studies suggested direct several pathophysiological pathways, such endothelial dysfunction platelet aggregation; moreover, observational data confirmed relationship with different conditions, including coronary artery disease, heart failure, hypertension. Despite significant evidence available so far, most clinical trials failed prove any positive impact supplements on cardiovascular outcomes. This discrepancy indicates need for further information knowledge about metabolism effect system, order identify those patients who would benefit from supplementation.

Language: Английский

Citations

8
Guidance on risk–benefit assessment of foods DOI Creative Commons
Simon J. More,

Diane Benford,

Susanne Hougaard Bennekou

et al.

EFSA Journal, Journal Year: 2024, Volume and Issue: 22(7)

Published: July 1, 2024

The EFSA Scientific Committee has updated its 2010 Guidance on risk-benefit assessment (RBA) of foods. update addresses methodological developments and regulatory needs. While it retains the stepwise RBA approach, provides additional methods for complex assessments, such as multiple chemical hazards all relevant health effects impacting different population subgroups. guidance includes approaches systematic identification, prioritisation selection hazardous beneficial food components. It also offers updates to characterising adverse effects, measures effect size dose-response modelling. expands options risks benefits, incorporating variability, uncertainty, severity categorisation ranking (beneficial or adverse) effects. impact types is assessed qualitatively quantitatively, depending problem formulation, scope question data availability. integration benefits often involves value-based judgements should ideally be performed with manager. Metrics Disability-Adjusted Life Years (DALYs) Quality-Adjusted (QALYs) can used. Additional are presented, probability and/or given severities their using weight functions. practical reporting results, interpreting outcomes communicating outcome an RBA, considering consumer perspectives responses advice.

Language: Английский

Citations

8
Vitamin D fortification of foods – sensory, acceptability, cost, and public acceptance considerations DOI Creative Commons
Kevin D. Cashman

The Journal of Steroid Biochemistry and Molecular Biology, Journal Year: 2024, Volume and Issue: 239, P. 106494 - 106494

Published: Feb. 25, 2024

Language: Английский

Citations

7
Modelling vitamin D fortification scenarios for the Australian population DOI
Eleanor Dunlop, A Lawrence, Belinda Neo

et al.

Journal of Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Vitamin D status in Norwegian children and associations between child vitamin D status, dietary factors, and maternal vitamin D status DOI Creative Commons
Anne Lene Kristiansen, Jannicke Borch Myhre,

Linn K. L. Øyri

et al.

Food & Nutrition Research, Journal Year: 2025, Volume and Issue: 69

Published: Feb. 5, 2025

Background and aims: There is limited data regarding the vitamin D status of infants young children in Norway. We aimed to assess among Norwegian at approximately 6 12 months age explore associations between child status, dietary factors, maternal status. Methods: Mothers/parents completed a food frequency questionnaire for their 6/12-month-old child. Dried blood spot samples were collected from mother Results: The mean serum 25-hydroxyvitamin (S-25(OH)D) concentration was 81 nmol/L (standard deviation [SD] 22 nmol/L) 6-month-old (n = 84) 72 (SD 12-month-old 56) (P 0.03 difference groups). In younger older groups, 94 88% children, respectively, had S-25(OH)D ≥ 50 nmol/L. intake μg/day 6-month-olds 14 12-month-olds. Adjusted linear regression models showed that every increase intake, 25(OH)D (nmol/L) increased by around one both groups 0.002 group P 0.04 group). Use supplements associated with higher concentrations while formula users found only youngest group. Breastfeeding not either Small positive correlations observed (r 0.22) 0.28) Conclusion: While there wide range most within sufficient range. Adequate should be encouraged first second year life.

Language: Английский

Citations

0
Vitamin E (α-Tocopherol): Emerging Clinical Role and Adverse Risks of Supplementation in Adults DOI Open Access
Alan D. Kaye,

Anne Thomassen,

Sydney A. Mashaw

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Vitamin E, primarily in its active form α-tocopherol, is a well-known antioxidant that protects cells from oxidative stress and free radical damage. It plays an essential role maintaining cellular integrity supporting immune function, making E widely popular easily accessible dietary supplement for overall health wellness. However, high-dose supplementation has become concern related to potential risks. The scientific research surrounding the safety efficacy of complex yet emphasizes balance use supplementation. Excessive or causes shift this balance, as E's beneficial properties are outweighed by harmful interference normal processes such immunity, cell growth, stress. An additional complication involves anticoagulant effects, which have been shown amplify risk bleeding when combined with blood thinners warfarin aspirin. Studies linked adverse outcomes, including enhanced risks all-cause mortality, hemorrhagic stroke, cardiovascular events, certain cancers. These particularly significant individuals pre-existing conditions heart failure, coagulation disorders, history stroke. side effects need further into This review will provide comprehensive analysis multifaceted physiology, focusing on navigating between benefits

Language: Английский

Citations

0
Quantifying vitamin D intake among Aboriginal and Torres Strait Islander peoples in Australia DOI Creative Commons
Belinda Neo,

Dale Tilbrook,

Noel Nannup

et al.

European Journal of Clinical Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Abstract Background/Objective Vitamin D deficiency (serum 25-hydroxyvitamin [25(OH)D] concentration < 50 nmol/L) is prevalent among Aboriginal and Torres Strait Islander peoples in Australia. Alternative to sun exposure (the primary source of vitamin D), can also be obtained from food (e.g. fish, eggs, meat) supplements. However, the intake this population group unknown. We aimed provide first quantification using nationally representative data peoples. Methods used consumption collected 2012–2013 National Nutrition Physical Activity Survey ( n = 4109) composition quantify by sex, age group, remoteness location. Wilcoxon rank-sum test was assess difference between sexes Results The median (25th, 75th percentile) aged ≥ 2 years 80 (45, 145) IU/day. statistically significantly different males females p 0.001). There no significant non-remote remote areas 0.292). Conclusions low. Food-based public health strategies guided Elders communities could developed promote higher population.

Language: Английский

Citations

0
Vitamin D status in children undergoing allogeneic hematopoietic stem cell transplantation: A prospective exploratory study DOI Open Access
Janne Anita Kvammen, Rut Anne Thomassen, Jochen Buechner

et al.

Journal of Pediatric Gastroenterology and Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Abstract Objectives Allogeneic hematopoietic stem cell transplantation (HSCT) is associated with nutritional risks. This study describes vitamin D status and intake in children undergoing HSCT compares results to healthy children. Methods In a prospective observational study, 25(OH)D 1,25(OH) 2 were assessed at hospital admission before (baseline), 3‐month 1‐year post‐transplant. Vitamin deficiency was defined as < 50 nmol/L. A 4‐day diet record 3‐months 1‐year. Healthy once. Results Twenty‐eight patients (mean age: 10.3‐years, standard deviation [SD]: 4.0) 10.0‐years, SD: 3.6) included. more prevalent baseline (36%, p 0.001) (24%, = 0.007) but not (14%, 0.084) than (2%). Median significantly lower the two first visits ( 0.198). provision higher (18.1 µg/day) (25 compared (5.3 µg/day, 0.001). Conclusions Children high risk of post‐transplant, after These findings indicate that requirements are elevated patients, emphasizing need for monitoring adequate supplementation. Trial Registration Clinical Trials AEV2017/1. 2016/391/REK sør‐øst B.

Language: Английский

Citations

0