New approach methodologies (NAMs): identifying and overcoming hurdles to accelerated adoption

Toxicology Research, Journal Year: 2024, Volume and Issue: 13(2)

Published: March 1, 2024

Abstract New approach methodologies (NAMs) can deliver improved chemical safety assessment through the provision of more protective and/or relevant models that have a reduced reliance on animals. Despite widely acknowledged benefits offered by NAMs, there continue to be barriers prevent or limit their application for decision-making in assessment. These include related real and perceived scientific, technical, legislative economic issues, as well cultural societal obstacles may relate inertia, familiarity, comfort with established methods, perceptions around regulatory expectations acceptance. This article focuses science, exposure, hazard, risk assessment, explores nature these how they overcome drive wider exploitation acceptance NAMs. Short-, mid- longer-term goals are outlined embrace opportunities provided NAMs protection human health environmental security part new paradigm incorporates exposure science culture promotes use toxicological assessments.

Language: Английский

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Current and emerging issues in chemical food safety

Current Opinion in Food Science, Journal Year: 2025, Volume and Issue: unknown, P. 101284 - 101284

Published: Feb. 1, 2025

Language: Английский

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Novel foods, food enzymes, and food additives derived from food by-products of plant or animal origin: principles and overview of the EFSA safety assessment

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: May 3, 2024

The European Union (EU) is committed to transitioning toward a circular economy model, with food waste being one of the areas be targeted. To close loop generated during processing and discarded at retail or consumption phases, research innovation parties proposed valorize agro-food by-products produce novel foods improvement agents (food additives, enzymes, flavorings). In EU, authorization such governed by different regulatory frameworks. A centralized safety assessment Food Safety Authority (EFSA) prerequisite for their through so-called Lists. Up December 2023, EFSA published 45 scientific opinions on foods, additives derived from plant animal origin. current study illustrates examples these production data requirements behind respective assessments conducted EFSA. this review, applications received were screened analyzed find common differences in terms evaluation products. Various (i.e., corncobs, coffee husks, spent grains barley rice, grape pomace, pumpkin peels, bovine whey, eggshells, shrimp heads, organs tissues) described as processed (extraction, physical treatments, chemical enzymatic reactions) obtain agents. heterogeneity complexity products emphasize challenge assessment, depending characteristics each product. However, shows, underpinning do not differ substantially regulated product considered, similar information needed assess identity, process, compositional characterization, proposed/intended uses exposure toxicological information, allergenicity data. Additional nutritional history use are required case foods.

Language: Английский

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An Overview of Current New Approach Methodologies for Developmental Toxicity and the Current Research Gaps

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Harnessing artificial intelligence in microbial food safety: global progress and implications in the ASEAN region

International Journal of Food Science & Technology, Journal Year: 2024, Volume and Issue: 59(10), P. 7754 - 7766

Published: May 15, 2024

Abstract Food safety remains one of the major concerns in ASEAN, with many recent developmental plans and published policies region being focused on topic. Most WHO data indicate that over 90% food burden ASEAN is due to microbial foodborne diseases. However, conventional systems for controlling FBDs are resource-intensive require significant infrastructure which may not yet be present ASEAN. Prior work use Artificial intelligence (AI) application has shown its potential reduce costs increase efficiency. there a paucity such research specific region. In this review, state unique challenges presented. The global state-of-the-art applications AI presented possible steps adaptation context then discussed.

Language: Английский

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Artificial intelligence-based data extraction for next generation risk assessment: Is fine-tuning of a large language model worth the effort?

Toxicology, Journal Year: 2024, Volume and Issue: 508, P. 153933 - 153933

Published: Aug. 23, 2024

To underpin scientific evaluations of chemical risks, agencies such as the European Food Safety Authority (EFSA) heavily rely on outcome systematic reviews, which currently require extensive manual effort. One specific challenge constitutes meaningful use vast amounts valuable data from new approach methodologies (NAMs) are mostly reported in an unstructured way literature. In EFSA-initiated project 'AI4NAMS', potential large language models (LLMs) was explored. Models GPT family, where refers to Generative Pre-trained Transformer, were used for searching, extracting, and integrating publications NAM-based risk assessment. A case study bisphenol (BPA), a substance very high concern due its adverse effects human health, focused structured extraction information test systems measuring biologic activities BPA. Fine-tuning GPT-3 model (Curie base model) tasks tested performance fine-tuned compared ready-to-use (text-davinci-002). update findings AI4NAMS check technical progress, fine-tuning exercise repeated newer (text-davinci-003) served comparison. both cases, Curie found be superior model. Performance improvement also obvious between text-davinci-002 text-davinci-003. Our demonstrate how swift general development improve contribute growing number investigations AI regulatory tasks.

Language: Английский

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Development of a roadmap for action on the application of Omics and associated Bioinformatics Approaches in Risk Assessment

EFSA Supporting Publications, Journal Year: 2024, Volume and Issue: 21(10)

Published: Oct. 1, 2024

Abstract The implementation of omics technologies and associated bioinformatics approaches hold significant promise for generating additional evidence food feed risk assessments thereby enhancing the European Food Safety Authority (EFSA) capacity to deliver scientific opinions guidance documents in future. To explore this possibility, EFSA launched a Call development roadmap identify main actions needed wider use Omics future assessments. address objective, action outlines six project proposals. These proposals are based on comprehensive mapping state‐of‐the‐art research, EFSA's activities as well current planned from other relevant regulatory bodies organisations. outlined recommendations also some identified knowledge gaps highlight added value that further investments different & safety domains could bring. In addition, work addresses key challenges blockers might hinder integration assessment leverages opportunities cooperation with external stakeholders. Finally, provides suggestions how may more broadly effectively engage stakeholders science.

Language: Английский

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New Approach Methodologies (NAMs) to Support Regulatory Decisions for Chemical Safety

FSA research and evidence., Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

Language: Английский

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