Journal of Research in Pharmacy, Journal Year: 2024, Volume and Issue: 28(2)(28(2)), P. 470 - 481
Published: Jan. 1, 2024
This study investigates the encapsulation of bakuchiol, a renowned compound for hyperpigmentation treatment, utilizing transfersomes as delivery system.The were fabricated using thin-film hydration technique and subjected to thorough characterization across various parameters.The resulting transfersome formulation, after optimization, demonstrated notably high efficiencies, with bakuchiol registering at 86.7±3.6%,accompanied by narrow particle size distribution (179.9 ± 5.4 nm).In vitro release studies unveiled cumulative percentages 71.98±6.52%for over 24-hour period.Ex vivo permeation further affirmed heightened retention within skin layers compared control group.Stability assessments indicated that optimized remained stable 5°C least 90 days.These findings underscore remarkable potential in facilitating offering compelling viable alternative formulations.
Language: Английский