PLoS ONE, Journal Year: 2024, Volume and Issue: 19(10), P. e0309389 - e0309389

Published: Oct. 31, 2024

This study reports the facile hydrothermal synthesis of pure Bi2WO6 and Bi2WO6\MWCNTs nanocomposite at specific molar ratio 1:2.5 Bi2WO6:MWCNTs elucidates their role in modulating NLRP3 inflammasome pathway via autophagy induction. Comprehensive characterization techniques, including XRD, Raman, UV.Vis PL,FESEM,EDS TEM, revealed successful incorporation MWCNTs into structures, leading to enhanced crystattlinity, reduced band gap energy (2.4 eV) suppressed charge carrier recombination mitigated nanoparticles aggregation. Notably, facikitaed improved visible light harvesting, a crucial attribute for photocatalytic applications. Significantly, nanocompsoite exhibited remarkable capacity augment bone marrow-derived macrophages (BMDMs), consequently down-regulating inflammasom activation IL-1β secretion upon LPS ATP stimulation. Immunofluorescence assays unveiled increased co-localization LC3 NLRP3, suggestion targeting by autophagy. Inhibition 3-MA reversed these effects, confirming pivotal Furthermore, attenuated caspase-1 ASC oligomerzation, thereby impeding assembly. Collectively, findings underscore potential nanocompsite as multifaceted therapeutic platform, levering its tailored optoelectronic properties sbility modulate infalmmasome augmentation. work covers way development advanced nanomaterials with tunable functionalities combating inflammatory disorders antimicrobial

Language: Английский