Protective effect and mechanism of CoQ10 in mitochondrial dysfunction in diquat‐induced renal proximal tubular injury

Journal of Biochemical and Molecular Toxicology, Journal Year: 2024, Volume and Issue: 38(11)

Published: Oct. 21, 2024

Abstract Coenzyme Q10 (CoQ10) plays an important role in improving mitochondrial function and has many beneficial effects on the kidney. However, whether CoQ10 protects against diquat (DQ)‐induced acute kidney injury (AKI) remains unclear. In this study, we investigated protective mechanism of action DQ‐induced AKI. Institute Cancer Research (ICR) mice were intraperitoneally injected with DQ to induce The expression levels serum creatinine (Cr), urea, molecule‐1 (KIM‐1) increased, those aquaporin 1 (AQP‐1) decreased, reactive oxygen species (ROS) increased depolarization membranes rupture. contrast, treatment significantly improved reduced Cr, KIM‐1 contents, AQP‐1 expression, ROS contents poisoning. Our results suggest that AKI caused by poisoning may be related disruption homeostasis kinetic homeostasis. Thus, represents a new therapeutic option for prevention

Language: Английский

Effect of ethyl acetate extract from Usnea longissima on chemotherapy-associated multiple organ dysfunction in rats

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 181, P. 117636 - 117636

Published: Nov. 2, 2024

Language: Английский