trans -Tiliroside and (+)-pinoresinol: polyphenols against albumin glycation, α-glucosidase activity and ROS formation, with in silico pharmacokinetic evaluation

Natural Product Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9

Published: April 22, 2025

trans-Tiliroside and (+)-pinoresinol, a flavonoid lignan found in plants traditionally used for diabetes mellitus care, were investigated antidiabetic properties through vitro silico studies. Four assays conducted: Bovine Serum Albumin (BSA) assay to assess inhibition of albumin glycation, α-glucosidase evaluate decrease carbohydrate digestion, Oxygen Radical Absorbance Capacity (ORAC) antioxidant activity cytotoxicity evaluation on HT-29 cells. showed higher protein with IC50 values 113.6, 71.03 95.73 µM against glucose, fructose ribose-induced respectively. Moreover, trans-tiliroside demonstrated capacity than (+)-pinoresinol. Both compounds slight inhibitory no cells at 0.1-100 µM. An pharmacokinetic study evaluated their bioavailability. Results suggest can act as an inhibitor potentially reducing unwanted glycation reactions preventing hyperglycaemia-related diseases.

Language: Английский

Rhododendri Daurici Folium: An Overview of Studies on the Study of Herbal Medicine, Chemical Composition, Pharmacological Action, Clinical Application, and Quality Control

Phytochemical Analysis, Journal Year: 2025, Volume and Issue: unknown

Published: May 19, 2025

ABSTRACT The Rhododendri Daurici Folium (RDF) represents the desiccated foliage of Rhododendron dauricum L., belonging to family. RDF abounds in diverse chemical elements, predominantly flavonoids, volatile oils, phenols, coumarin, and lignans. functions as a cough expectorant agent, primarily employed management acute chronic bronchitis pharyngitis. is also known for its pharmacological properties, including antibacterial, cardiotonic, antihypertensive, anticancer properties. frequently utilized potent ingredient Yingshanhong tablets, compound syrup, XiaoKeChuan various traditional Chinese medicinal concoctions, it holds significant importance clinical settings. This article's data were sourced from publications PubMed, CNCK, SCI‐HUB, Web Science, Scopus, Pharmacopoeia, Dictionary Traditional Medicine, Flora, associated studies. present document provides comprehensive examination herbal effects, makeup, application, quality assurance, safety assessments RDF, serving guide advancing applying medicine RDF.

Language: Английский