Impact of QazVac vaccination on clinical manifestations and immune responses in post—COVID syndrome: a cross-sectional study

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 26, 2025

Introduction Post-COVID syndrome, also known as long COVID, has emerged a major public health concern, affecting substantial proportion of individuals recovering from SARS-CoV-2 infection. This condition is characterized by persistent symptoms lasting at least 2 months after acute infection, significantly impacting quality life and increasing healthcare burdens. In Kazakhstan, the recognition post- COVID syndrome in national clinical protocols highlights need for effective prevention management strategies. Vaccination been suggested key intervention to reduce severity prevalence symptoms, yet data on its effectiveness, particularly domestic QazVac vaccine, remain limited. The aim this study investigate impact vaccination with vaccine features humoral cellular immunity patients post-COVID conditions identify leading variants course. Methods We analyzed 90 vaccinated 217 non-vaccinated patients, examining sex, age, smoking status, BMI, comorbidities, manifestations. Results There were no significant differences between groups regard status. However, characteristics subjects indicated that was correlated lower diabetes mellitus (2.2% vs. 11.1%, p = 0.011) cardiovascular diseases (0.0% 10.1%, 0.047), higher hypertension among subjects. With presented decreased frequency neurological (51.1% 74.2%, 0.001), gastrointestinal (4.4% 15.2%, 0.008), respiratory (21.1% 36.4%, 0.009), rheumatological (26.7% 38.7%, 0.044), kidney 9.7%, 0.024). contrast, unvaccinated participants had more memory loss (49.8% 22.2%, < depression (31.3% 6.7%, joint pain (33.2% 14.4%, other psychopathological symptoms. Discussion A sharp decrease neurological, gastrointestinal, respiratory, recorded advocating protective role against COVID-19 sequelae. These findings highlight potential mitigate burden complications across various organ systems.

Language: Английский

ScRNA-Seq reveals T cell immunity in COVID-19 patients and implications for immunotherapy

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 155, P. 114663 - 114663

Published: April 14, 2025

Language: Английский