Triple Negative Breast Cancer (TNBC): Cannabis sativa-Role of Phytocannabinoids DOI Creative Commons
Ravindra B. Malabadi,

Kiran P. Kolkar,

Sadiya MR

et al.

World Journal of Biology Pharmacy and Health Sciences, Journal Year: 2024, Volume and Issue: 17(3), P. 140 - 179

Published: March 16, 2024

This review paper highlights the role of phytocannabinoids in controlling triple-negative breast cancer (TNBC). Triple-negative (TNBC) is a specific subtype that does not express estrogen receptor (ER), progesterone (PR), or human epidermal growth factor 2 (HER-2), which has clinical features include high invasiveness, metastatic potential, proneness to relapse, and poor prognosis. TNBC one most aggressive subtypes often associated with patient outcomes because development metastases secondary organisms like brain, bone, lungs. kind have any receptors are commonly found cancer. The highest number cases been recorded India. Currently, highly prevalent among Indian women develops approximately 20% 43% all patients an malignancy requires effective targeted drug therapy. Patients develop metastasis recurrence over time reduced survival compared other Pre-clinical studies demonstrated exert important antitumor properties main subtypes, particularly TNBC, where different synthetic cannabinoids shown interesting therapeutic actions. Neither CBD nor THC universally efficacious reducing cell viability. Focusing on vitro studies, effect viability ranges from no effect, modest reduction, significant cytotoxicity depending concentrations, lines, conditions, performed assays, exposure. However, it should also be noted research into efficacy, dosage safety tumor therapy still long way go, especially regard trials conducted, through alone benefits advantages for but possible risks can defined.

Language: Английский

Role of Plant derived-medicine for controlling Cancer DOI Creative Commons
Ravindra B. Malabadi,

Sadiya MR,

Kiran P. Kolkar

et al.

International Journal of Science and Research Archive, Journal Year: 2024, Volume and Issue: 11(1), P. 2502 - 2539

Published: Feb. 28, 2024

This review paper has highlighted a list of plants containing active phytochemicals with anticancer potential, as well data supporting their use in cancer therapy, animal models, and pharmacological properties. Cancer is among the leading causes morbidity mortality worldwide. disease characterized by abnormal cell division proliferation that result from disruption molecular signals control these processes. abnormal, uncontrolled cells body. The when malignant, invade various parts body through bloodstream. spread its or tissue origin to another healthy part tissues organs called metastasis. Some regular characteristics cancers are apoptosis, angiogenesis, multiple replication, growth signal production, insensitivity anti-growth These features make have continuous growth, long time survival potential normal cells. Moreover, if activities not blocked, will continue increase, overwhelm finally kill patient cancer. Oncology study An oncologist doctor who treats provides medical care for person diagnosed may also be specialist. Today, despite considerable efforts, still remains an aggressive killer success rate therapies diminished toxicities, drug resistance, recurrence treatment failure. A significant challenge associated much art it science. Therefore, there constant demand develop new, effective, affordable drugs. Several factors, such environmental habitual activities, genetic etc., responsible Many patients seek alternative and/or complementary treatments because high death linked adverse side effects chemotherapy, radiation immunotherapy, surgery, stem therapy. Medicinal could possess effective compounds used adjuvants existing chemotherapy improve efficacy reduce drug-induced toxicity; chemotherapy-induced nausea vomiting patients’ quality life. Cell caused whole plant extracts via apoptosis. However, majority been researched prevention rather than treatment, resulting low uptake practice. Prevention certainly attractive management strategy. Thus might possible process carcinogenesis along lifestyle.

Language: Английский

Citations

8
Cannabis sativa: Cervical cancer treatment- Role of phytocannabinoids-A story of concern DOI Creative Commons
Ravindra B. Malabadi,

Sadiya MR,

Prathima TC

et al.

World Journal of Biology Pharmacy and Health Sciences, Journal Year: 2024, Volume and Issue: 17(2), P. 253 - 296

Published: Feb. 20, 2024

This litrature review paper highlights the role of phytocannabinoids in controlling cervical cancer. Cervical cancer is one leading causes death among females worldwide. (CC) a malignant form tumor which originates cervix. cancer, develops woman’s cervix, second-most common women India The causative agent persistent infection with high-risk subtypes Human Papillomavirus (HPV) and E5, E6 E7 viral onco-proteins cooperate host factors to induce maintain phenotype. papillomavirus responsible for subclinical/clinical lesions HPV types 16 18 are most identified invasive Currently, recommended therapeutic regimens include chemotherapy, radiation therapy either alone or combination surgical interventions. However, they present several limitations including side effects ineffectiveness. Medicinal plants Cannabis sativa have been used decades health benefits treat different diseases has thousands years recreational, medicinal, religious purposes. Phytocannabinoids cannabinoids that occur naturally cannabis plant. two well known their properties are, Δ9-tetrahydrocannabinol (THC) Cannabidiol (CBD). hold big promise therapy. there need understand more about Endocannabinoid system (ECS) normal human physiology transformations. Molecular mechanisms regulation anticancer also be clarified. treatment durations existing trials concern. Future epidemiological clinical studies required further assess herbal medicines prevention In addition, preclinical trial evaluations not specifically conducted, so investigations related this warranted. Therefore, immunization programme best ideal solution eradication

Language: Английский

Citations

4
Assessment of Microbiological Safety and Physiochemical Quality of Potable Jar Water in Dhaka, Bangladesh DOI

Rowson Habiba Tisha,

Jannatul Ferdose Supti,

Mahima Hossain Supti

et al.

Journal of Preventive Diagnostic and Treatment Strategies in Medicine, Journal Year: 2025, Volume and Issue: 4(1), P. 36 - 43

Published: Jan. 1, 2025

Abstract BACKGROUND: Worldwide, the most significant public health concern is safe drinking water. Consumption of untreated or poorly treated water major cause contracting diseases such as dysentery, diarrhea, and many more. Dhaka, capital Bangladesh, has been dealing with problems contamination, poor infrastructure, rising urbanization its delivery faulty jar production systems. METHODS: In this study, we have collected 20 different samples potable from areas in a 4-month study period to enumerate indicator microorganisms Escherichia coli Klebsiella pneumoniae through standard microbiological detection techniques. The physicochemical parameter analysis tests were also done assess quality RESULTS: result showed that samples, 16 indicated presence coliform fecal coliforms highest load 214 174 colony-forming units (CFU)/100 mL, respectively. antibiotic susceptibility pattern suspected bacterial isolates all E. 100% resistant cefuroxime, vancomycin, cefepime. On other hand, cefuroxime vancomycin. CONCLUSION: highlighted need for frequent surveillance millions city dwellers every day depend on it suggested hygienic needs be supplied human purposes. Preventive measures should focus improving treatment practices sanitation standards reduce contamination. Finally, strategies must address resistance, emphasizing responsible use development new therapeutic options.

Language: Английский

Citations

0
Prevalence and Serotype Distribution of Shiga Toxin-Producing Escherichia coli (STEC) in Raw Animal and Plant Food Samples from Kocaeli Province, Türkiye DOI
Adem Soycan, Doğanhan Kadir Er, Devrim Dündar

et al.

Food Control, Journal Year: 2025, Volume and Issue: 176, P. 111382 - 111382

Published: April 23, 2025

Language: Английский

Citations

0
Potential Application of Postbiotics as a Natural Preservative in Cheese DOI
Nader Khani, Amir Hessam Shakeri, Mir‐Hassan Moosavy

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Language: Английский

Citations

0
Plant-Derived Polysaccharides Benefit Weaned Piglets by Regulating Intestinal Microbiota: A Review DOI
Huang Xiao-yan, Faming Jiang,

X Chen

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

The intestine harbors a community of bacteria that is intestinal microbiota, which complex and highly diverse community. This review discusses the gut microbiota in piglets, including role homeostasis maintaining piglet health various factors influence microbiota. Nutritional interventions, particularly supplementation plant-derived polysaccharides, dietary fiber, for weaned piglets have been shown to enhance abundance colonization beneficial microbes, reduce incidence gastrointestinal infections, decrease frequency diarrhea, thereby improving growth performance. In this context, such as those derived from

Language: Английский

Citations

2
Triple Negative Breast Cancer (TNBC): Cannabis sativa-Role of Phytocannabinoids DOI Creative Commons
Ravindra B. Malabadi,

Kiran P. Kolkar,

Sadiya MR

et al.

World Journal of Biology Pharmacy and Health Sciences, Journal Year: 2024, Volume and Issue: 17(3), P. 140 - 179

Published: March 16, 2024

This review paper highlights the role of phytocannabinoids in controlling triple-negative breast cancer (TNBC). Triple-negative (TNBC) is a specific subtype that does not express estrogen receptor (ER), progesterone (PR), or human epidermal growth factor 2 (HER-2), which has clinical features include high invasiveness, metastatic potential, proneness to relapse, and poor prognosis. TNBC one most aggressive subtypes often associated with patient outcomes because development metastases secondary organisms like brain, bone, lungs. kind have any receptors are commonly found cancer. The highest number cases been recorded India. Currently, highly prevalent among Indian women develops approximately 20% 43% all patients an malignancy requires effective targeted drug therapy. Patients develop metastasis recurrence over time reduced survival compared other Pre-clinical studies demonstrated exert important antitumor properties main subtypes, particularly TNBC, where different synthetic cannabinoids shown interesting therapeutic actions. Neither CBD nor THC universally efficacious reducing cell viability. Focusing on vitro studies, effect viability ranges from no effect, modest reduction, significant cytotoxicity depending concentrations, lines, conditions, performed assays, exposure. However, it should also be noted research into efficacy, dosage safety tumor therapy still long way go, especially regard trials conducted, through alone benefits advantages for but possible risks can defined.

Language: Английский

Citations

1