Combating Multidrug Resistance: The Potential of Antimicrobial Peptides and Biofilm Challenges DOI Open Access

Heba A. Azmy,

Ahmed R. Sofy,

Akram Aboseidah

et al.

International Journal of Innovative Science and Research Technology (IJISRT), Journal Year: 2024, Volume and Issue: unknown, P. 307 - 335

Published: April 18, 2024

The escalating crisis of antibiotic resistance represents a formidable challenge to global public health, necessitating urgent and innovative solutions. This review delves into the multifaceted nature resistance, emphasizing pivotal role biofilms genetic mechanisms underpinning in both Gram-positive Gram-negative bacteria. A significant focus is placed on Staphylococcus aureus, particularly methicillin-resistant S. aureus (MRSA), its including SCCmec element agr quorum sensing system. also explores alarming rise pathogens, such as E. coli K. pneumoniae, highlighting perilous spread extended-spectrum β- lactamases (ESBLs) carbapenemases. Amidst this dire landscape, antimicrobial peptides (AMPs), melittin from bee venom (BV), emerge promising agents capable breaching microbial defenses, those dormant cells within biofilms, thus offering potential strategy circumvent traditional mechanisms. underscores necessity understanding bacterial survival strategies, biofilm formation adaptation, develop effective countermeasures against antibiotic-resistant infections.

Language: Английский

Combating Multidrug Resistance: The Potential of Antimicrobial Peptides and Biofilm Challenges DOI Open Access

Heba A. Azmy,

Ahmed R. Sofy,

Akram Aboseidah

et al.

International Journal of Innovative Science and Research Technology (IJISRT), Journal Year: 2024, Volume and Issue: unknown, P. 307 - 335

Published: April 18, 2024

The escalating crisis of antibiotic resistance represents a formidable challenge to global public health, necessitating urgent and innovative solutions. This review delves into the multifaceted nature resistance, emphasizing pivotal role biofilms genetic mechanisms underpinning in both Gram-positive Gram-negative bacteria. A significant focus is placed on Staphylococcus aureus, particularly methicillin-resistant S. aureus (MRSA), its including SCCmec element agr quorum sensing system. also explores alarming rise pathogens, such as E. coli K. pneumoniae, highlighting perilous spread extended-spectrum β- lactamases (ESBLs) carbapenemases. Amidst this dire landscape, antimicrobial peptides (AMPs), melittin from bee venom (BV), emerge promising agents capable breaching microbial defenses, those dormant cells within biofilms, thus offering potential strategy circumvent traditional mechanisms. underscores necessity understanding bacterial survival strategies, biofilm formation adaptation, develop effective countermeasures against antibiotic-resistant infections.

Language: Английский

Citations

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