Alternative Splicing Landscape of Head and Neck Squamous Cell Carcinoma

Technology in Cancer Research & Treatment, Journal Year: 2024, Volume and Issue: 23

Published: Jan. 1, 2024

Head and neck malignancies are a significant global health concern, with head squamous cell carcinoma (HNSCC) being the sixth most common cancer worldwide accounting for > 90% of cases. In recent years, there has been growing recognition potential role alternative splicing (AS) in etiology cancer. Increasing evidence suggests that AS is associated various aspects progression, including tumor occurrence, invasion, metastasis, drug resistance. Additionally, involved shaping microenvironment, which plays crucial development response to therapy. can influence expression factors angiogenesis, immune response, extracellular matrix remodeling, all contribute formation supportive microenvironment growth. Exploring mechanism events HNSCC could provide insights into progression this cancer, as well its interaction microenvironment. Understanding how contributes molecular changes cells influences lead identification new therapeutic targets. Targeted chemotherapy immunotherapy strategies tailored specific patterns potentially improve treatment outcomes reduce side effects. This review explores concept, types, processes, technological advancements AS, focusing on initiation, treatment, prognosis HNSCC.

Language: Английский

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Multi-modal transcriptomic analysis reveals metabolic dysregulation and immune responses in chronic obstructive pulmonary disease

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 30, 2024

Language: Английский

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Aging and head and neck cancer insights from single cell and spatial transcriptomic analyses

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 18, 2024

Head and neck squamous cell carcinoma(HNSCC) is the sixth most common malignancy worldwide, with more than 890,000 new cases 450,000 deaths annually. Its major risk factors include smoking, alcohol abuse, aging, poor oral hygiene. Due to lack of early effective detection screening methods, many patients are diagnosed at advanced stages a five-year survival rate less 50%. In this study, we deeply explored expression Aging-related genes(ARGs) in HNSCC analyzed their prognostic significance using single-cell sequencing spatial transcriptomics analysis. This research aims provide theoretical support directions for personalized treatment. Annually, head carcinoma (HNSCC) globally, leading deaths, making it worldwide. The primary Many due absence resulting research, single transcriptome analysis were used investigate genes (ARGs) analyse significance.

Language: Английский

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SP110 Could be Used as a Potential Predictive and Therapeutic Biomarker for Oral Cancer

Molecular Biotechnology, Journal Year: 2024, Volume and Issue: unknown

Published: June 28, 2024

Language: Английский

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