Involvement of the left uncinate fasciculus in the amyotrophic lateral sclerosis: an exploratory longitudinal multi-modal neuroimaging and neuropsychological study DOI
Sadegh Ghaderi, Farzad Fatehi, Sanjay Kalra

et al.

Brain Structure and Function, Journal Year: 2024, Volume and Issue: 230(1)

Published: Dec. 17, 2024

Language: Английский

Regional Cerebral Atrophy Contributes to Personalized Survival Prediction in Amyotrophic Lateral Sclerosis: A Multicentre, Machine Learning, Deformation‐Based Morphometry Study DOI Creative Commons

Isabelle Lajoie,

Sanjay Kalra, Mahsa Dadar

et al.

Annals of Neurology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 22, 2025

Objective Accurate personalized survival prediction in amyotrophic lateral sclerosis is essential for effective patient care planning. This study investigates whether grey and white matter changes measured by magnetic resonance imaging can improve individual predictions. Methods We analyzed data from 178 patients with 166 healthy controls the Canadian Amyotrophic Lateral Sclerosis Neuroimaging Consortium study. A voxel‐wise linear mixed‐effects model assessed disease‐related survival‐related atrophy detected through deformation‐based morphometry, controlling age, sex, scanner variations. Additional models explored associations between regional clinical measurements, their time to composite outcome of death, tracheostomy, or permanent assisted ventilation. evaluated incorporating features alongside could performance an distribution model. Results Deformation‐based morphometry uncovered distinct patterns linked disease progression survival, many these atrophies significantly associated manifestations disease. By integrating data, we observed a substantial enhancement across key metrics. Our analysis identified specific brain regions, such as corpus callosum, rostral middle frontal gyrus, thalamus, where predicted increased risk mortality. Interpretation suggests that provide valuable insights beyond assessments prognosis. It offers more comprehensive approach prognosis highlights regions involved potentially leading better understanding sclerosis. ANN NEUROL 2025

Language: Английский

Citations

1
Quantitative susceptibility mapping in amyotrophic lateral sclerosis: automatic quantification of the magnetic susceptibility in the subcortical nuclei DOI
Sadegh Ghaderi, Farzad Fatehi, Sanjay Kalra

et al.

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 12

Published: July 3, 2024

: Previous studies have suggested a link between dysregulation of cortical iron levels and neuronal loss in amyotrophic lateral sclerosis (ALS) patients. However, few reported differences quantitative susceptibility mapping (QSM) values subcortical nuclei patients with ALS healthy controls (HCs).

Language: Английский

Citations

7
Volume loss in the left anterior‐superior subunit of the hypothalamus in amyotrophic lateral sclerosis DOI Creative Commons
Sadegh Ghaderi, Farzad Fatehi, Sanjay Kalra

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(6)

Published: June 1, 2024

Amyotrophic lateral sclerosis (ALS) causes motor neuron loss and progressive paralysis. While traditionally viewed as disease (MND), ALS also affects non-motor regions, such the hypothalamus. This study aimed to quantify hypothalamic subregion volumes in patients with versus healthy controls (HCs) examine their associations demographic clinical features.

Language: Английский

Citations

6
Cross-Sectional and Longitudinal Patterns of Atrophy in Thalamic and Deep Gray Matter Nuclei in Frontotemporal Dementia DOI
Arit Banerjee, Fan Yang, Joyita Dutta

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Frontotemporal dementia involves progressive atrophy in deep gray matter nuclei, including the thalamus and basal ganglia (such as caudate, putamen, nucleus accumbens, globus pallidus), which are critical for cognition behavior. This study examined cross-sectional longitudinal using a state-of-the-art multi-atlas segmentation method sTHOMAS. T1-weighted MRI scans from 274 participants at baseline 237 follow-up obtained Lobar Degeneration Neuroimaging Initiative database were analyzed Group differences assessed ANCOVA, adjusting age, gender intracranial volume covariates. Atrophy was significant mediodorsal, pulvinar, anterior ventral claustrum, with bvFTD most affected cross-sectionally. Longitudinally, pulvinar nuclei declined further. correlated naming (mediodorsal), working memory (ventrolateral posterior), executive dysfunction (nucleus accumbens) neuropsychological tests. These findings highlight progressive, nucleus-specific FTD emphasize importance of well imaging sex-specific analyses understanding disease progression.

Language: Английский

Citations

0
Metabolite Alterations in the Left Dorsolateral Prefrontal Cortex and its Association with Cognitive Assessments in Amyotrophic Lateral Sclerosis: A Longitudinal Magnetic Resonance Spectroscopy Study DOI Creative Commons
Sadegh Ghaderi, Farzad Fatehi, Sanjay Kalra

et al.

Brain Research Bulletin, Journal Year: 2024, Volume and Issue: 219, P. 111125 - 111125

Published: Nov. 13, 2024

To characterize the longitudinal metabolite profile of left dorsolateral prefrontal cortex (DLPFC) in amyotrophic lateral sclerosis (ALS) using magnetic resonance spectroscopy (MRS) and to examine its correlation with cognitive assessments.

Language: Английский

Citations

0
Involvement of the left uncinate fasciculus in the amyotrophic lateral sclerosis: an exploratory longitudinal multi-modal neuroimaging and neuropsychological study DOI
Sadegh Ghaderi, Farzad Fatehi, Sanjay Kalra

et al.

Brain Structure and Function, Journal Year: 2024, Volume and Issue: 230(1)

Published: Dec. 17, 2024

Language: Английский

Citations

0