Harnessing ferroptosis for precision oncology: challenges and prospects

BMC Biology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 24, 2025

Language: Английский

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Immunity and neuroinflammation in early stages of life and epilepsy

Epilepsia, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Abstract The immune system is crucial for the correct brain development, and recent findings also point toward central control of response. As not fully developed at birth, early years become an important window infections development epilepsy. Both even peripheral inflammation may impact function, promoting opening blood–brain/blood cerebrospinal barriers allowing entry cells cytokines, which in turn affect neuron function connections. resident cells, microglia, besides providing protection, neurons, myelination, astrocyte function. They may, via complement system, remove synapses, both physiologically pathologically. After seizures during activated microglia releases proinflammatory molecules, are detrimental inhibition microglial activation shows promising antiepileptogenic effects. In addition to excessive excitability stimulate calpain 2 expression, can promote loss contribute amplification inflammatory responses stimulation cytokines. summary, immature postnatal life be target long‐desired drugs.

Language: Английский

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The miR-34a-5p Promotes Hippocampal Neuronal Ferroptosis in Epilepsy by Regulating SIRT1

Neurochemical Research, Journal Year: 2025, Volume and Issue: 50(2)

Published: March 24, 2025

Language: Английский

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Lipid metabolism: Novel approaches for managing idiopathic epilepsy

Neuropeptides, Journal Year: 2024, Volume and Issue: 108, P. 102475 - 102475

Published: Sept. 30, 2024

Language: Английский

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