sTREM2 and cerebral blood flow in White Matter Hyperintensity Patients: Associations with Cognitive Impairment DOI
Man Zhang, Xiaoqun Zhu

Published: May 15, 2025

Background: White matter hyperintensities (WMHs) are common neuroimaging markers of cerebral small vessel disease (CSVD) and strongly associated with cognitive impairment. While hypoperfusion neuroinflammation recognized as major contributors to WMH pathology, the interplay between inflammatory biomarkers blood flow (CBF) remains poorly understood. Soluble triggering receptor expressed on myeloid cells 2 (sTREM2), a marker microglial activation, may play dual role in vascular dysfunction. Methods: A total 138 participants aged 50–80 years were enrolled, including 75 individuals group 63 healthy control (HC) group. All subjects underwent magnetic resonance imaging (MRI) arterial spin labeling(ASL) for CBF quantification neuropsychological assessments. Serum sTREM2 levels measured. Group comparisons, logistic regression, partial correlation analyses performed explore associations among sTREM2, CBF, performance. Results: Compared HC group, serum significantly elevated (P = 0.036), gray matter(GM) was lower 0.038). Logistic regression identified (OR 1.041, P 0.006) age 1.081, 0.018) independent risk factors WMHs. Partial revealed positive association controls, but negative Additionally, GM positively correlated global scores (MMSE, MoCA) executive function (Stroop Test C) Conclusion: Our findings suggest that higher reduced brain perfusion be closely linked presence progression white decline. Notably, direction relationship appears vary by status, indicating possible shift from compensatory harmful inflammation. These results highlight clinical value combining identifying at vessel-related impairment provide useful targets early intervention monitoring.

Language: Английский

sTREM2 and cerebral blood flow in White Matter Hyperintensity Patients: Associations with Cognitive Impairment DOI
Man Zhang, Xiaoqun Zhu

Published: May 15, 2025

Background: White matter hyperintensities (WMHs) are common neuroimaging markers of cerebral small vessel disease (CSVD) and strongly associated with cognitive impairment. While hypoperfusion neuroinflammation recognized as major contributors to WMH pathology, the interplay between inflammatory biomarkers blood flow (CBF) remains poorly understood. Soluble triggering receptor expressed on myeloid cells 2 (sTREM2), a marker microglial activation, may play dual role in vascular dysfunction. Methods: A total 138 participants aged 50–80 years were enrolled, including 75 individuals group 63 healthy control (HC) group. All subjects underwent magnetic resonance imaging (MRI) arterial spin labeling(ASL) for CBF quantification neuropsychological assessments. Serum sTREM2 levels measured. Group comparisons, logistic regression, partial correlation analyses performed explore associations among sTREM2, CBF, performance. Results: Compared HC group, serum significantly elevated (P = 0.036), gray matter(GM) was lower 0.038). Logistic regression identified (OR 1.041, P 0.006) age 1.081, 0.018) independent risk factors WMHs. Partial revealed positive association controls, but negative Additionally, GM positively correlated global scores (MMSE, MoCA) executive function (Stroop Test C) Conclusion: Our findings suggest that higher reduced brain perfusion be closely linked presence progression white decline. Notably, direction relationship appears vary by status, indicating possible shift from compensatory harmful inflammation. These results highlight clinical value combining identifying at vessel-related impairment provide useful targets early intervention monitoring.

Language: Английский

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