The multiscale topological organization of the functional brain network in adolescent PTSD DOI Open Access
David Corredor, Shailendra Segobin, Thomas Hinault

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 22, 2023

Abstract The experience of an extremely aversive event can produce enduring deleterious behavioral and neural consequences, among which posttraumatic stress disorder (PTSD) is a representative example. In this work, we aim to study the whole-cortex functional organization adolescents with PTSD without priori selection specific regions interest or networks. To do so, built on network neuroscience framework specifically multisubject community analysis connectivity brain. We show, across different topological scales (the number communities composing cortex), increased coupling between belonging unimodal (sensory) reduced transmodal (association) in adolescent group. These results open up intriguing possibility concerning altered large-scale cortical PTSD. Significance Statement understanding brain responses following traumatic eventual apparition symptoms during youth remains active topic research clinical neuroscience. adapted detection algorithm from whole cortex multiscale perspective, thereby taking into account complex (network) patients control subjects presented that remained present scales. showed decreased interaction cortices and, inversely, enhanced cortices. This investigation highlights importance studying perspective.

Language: Английский

The multiscale topological organization of the functional brain network in adolescent PTSD DOI Open Access
David Corredor, Shailendra Segobin, Thomas Hinault

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 22, 2023

Abstract The experience of an extremely aversive event can produce enduring deleterious behavioral and neural consequences, among which posttraumatic stress disorder (PTSD) is a representative example. In this work, we aim to study the whole-cortex functional organization adolescents with PTSD without priori selection specific regions interest or networks. To do so, built on network neuroscience framework specifically multisubject community analysis connectivity brain. We show, across different topological scales (the number communities composing cortex), increased coupling between belonging unimodal (sensory) reduced transmodal (association) in adolescent group. These results open up intriguing possibility concerning altered large-scale cortical PTSD. Significance Statement understanding brain responses following traumatic eventual apparition symptoms during youth remains active topic research clinical neuroscience. adapted detection algorithm from whole cortex multiscale perspective, thereby taking into account complex (network) patients control subjects presented that remained present scales. showed decreased interaction cortices and, inversely, enhanced cortices. This investigation highlights importance studying perspective.

Language: Английский

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