Resting After Learning Facilitates Memory Consolidation and Reverses Spatial Reorientation Impairments in 'New Surroundings' in 3xTg-AD Mice DOI Open Access
Alina C. Stimmell,

Leslie J. Alday,

Jose Diaz

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 14, 2024

Sleep is an essential component of productive memory consolidation and waste clearance, including pathology associated with Alzheimer's disease (AD). Facilitation sleep decreases Aβ tau accumulation important for the spatial memories. We previously found that 6-month female 3xTg-AD mice were impaired at reorientation. Given association between AD, we assessed impact added rest on reorientation observed. randomly assigned to a (n=7; 50 min pre- & post-task induced rest) or non-rest group remained in home cage post-task). Mice both groups compared non-Tg, age-matched, controls (n=6). To confirm our condition sleep, performed same experiment sessions non-Tg (n=6/group) implanted recording electrodes capture local field potentials (LFPs), which used classify states. Markers also parietal-hippocampal network, where showed pTau positive cell density predicted ability (pTau, 6E10, M78, M22). However, not better than (replicating previous work). This recovered behavior persisted despite no change cells. Thus, improving early stages AD offers promising approach facilitating cognition.

Language: Английский

Resting After Learning Facilitates Memory Consolidation and Reverses Spatial Reorientation Impairments in 'New Surroundings' in 3xTg-AD Mice DOI Open Access
Alina C. Stimmell,

Leslie J. Alday,

Jose Diaz

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 14, 2024

Sleep is an essential component of productive memory consolidation and waste clearance, including pathology associated with Alzheimer's disease (AD). Facilitation sleep decreases Aβ tau accumulation important for the spatial memories. We previously found that 6-month female 3xTg-AD mice were impaired at reorientation. Given association between AD, we assessed impact added rest on reorientation observed. randomly assigned to a (n=7; 50 min pre- & post-task induced rest) or non-rest group remained in home cage post-task). Mice both groups compared non-Tg, age-matched, controls (n=6). To confirm our condition sleep, performed same experiment sessions non-Tg (n=6/group) implanted recording electrodes capture local field potentials (LFPs), which used classify states. Markers also parietal-hippocampal network, where showed pTau positive cell density predicted ability (pTau, 6E10, M78, M22). However, not better than (replicating previous work). This recovered behavior persisted despite no change cells. Thus, improving early stages AD offers promising approach facilitating cognition.

Language: Английский

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