Neural Correlates of Resilience to Trauma During Adolescence: A Multi-Modal Study DOI
Lu Zhang, Vanessa Cropley, Divyangana Rakesh

et al.

Published: July 6, 2024

Background: Understanding resilience mechanisms is important for advancing early intervention strategies, yet research on the neurobiology of in adolescents limited. The present study examined brain structural and resting-state functional connectivity (rsFC) correlates to internalizing externalizing symptoms a large sample adolescents. Methods: We analyzed longitudinal data from 8,499 (baseline mean age 9.92 0.62 years) Adolescent Brain Cognitive Development Study. Participants were categorized as resilient, maladaptive, healthy, or vulnerable based reports traumatic events internalizing/externalizing three years later. used multinomial logistic regressions examine associations structure rsFC with resilience. Sex differences also investigated. Results: Increased odds being resilient (relative healthy) both associated between dorsal ventral attention networks hippocampus. Resilience was cingulo-opercular network found association fusiform cortical area, hippocampus, group membership maladaptive) be opposite directions males females. Conclusions: may involved salience detection encoding, some However, it unclear if our findings reflect specifically, could better interpreted reflecting trauma exposure psychopathology. This underscores need further into neurobiological basis during adolescence.

Language: Английский

Neural Correlates of Resilience to Trauma During Adolescence: A Multi-Modal Study DOI
Lu Zhang, Vanessa Cropley, Divyangana Rakesh

et al.

Published: July 6, 2024

Background: Understanding resilience mechanisms is important for advancing early intervention strategies, yet research on the neurobiology of in adolescents limited. The present study examined brain structural and resting-state functional connectivity (rsFC) correlates to internalizing externalizing symptoms a large sample adolescents. Methods: We analyzed longitudinal data from 8,499 (baseline mean age 9.92 0.62 years) Adolescent Brain Cognitive Development Study. Participants were categorized as resilient, maladaptive, healthy, or vulnerable based reports traumatic events internalizing/externalizing three years later. used multinomial logistic regressions examine associations structure rsFC with resilience. Sex differences also investigated. Results: Increased odds being resilient (relative healthy) both associated between dorsal ventral attention networks hippocampus. Resilience was cingulo-opercular network found association fusiform cortical area, hippocampus, group membership maladaptive) be opposite directions males females. Conclusions: may involved salience detection encoding, some However, it unclear if our findings reflect specifically, could better interpreted reflecting trauma exposure psychopathology. This underscores need further into neurobiological basis during adolescence.

Language: Английский

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