Lactic acid contributes to the emergence of depression-like behaviors triggered by blue light exposure during sleep DOI Creative Commons
Yinhan Li,

Xinhui Zou,

Ying Ma

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 289, P. 117643 - 117643

Published: Jan. 1, 2025

The threat posed by light pollution to human health is increasing remarkably. As demand for high-efficiency and bright lighting increases, so does the blue content from artificial sources. Although animal studies suggested induced depression-like behaviors, evidence remained limited, mechanisms which affects depression elusive. This study aimed investigate association between exposure in humans, explored underlying that driving behaviors light. Our population findings showed high-blue-light at night was positively associated with depressive symptoms. Lactic acid relevant Mendelian randomization analysis. Moreover, demonstrated during sleep (BLS) animals. Metabolomics colorimetric analyses revealed elevated levels of lactic cerebrospinal fluid lateral habenula (LHb) rats BLS. administration a lactate inhibitor (Oxamate) alleviated these along changes neuronal excitability, synaptic function, morphology LHb. Overall, our suggests excessive high light-content links increased symptoms, revealing possible molecular prevention strategies, are crucial addressing environmentally related mental issues.

Language: Английский

Lactic acid contributes to the emergence of depression-like behaviors triggered by blue light exposure during sleep DOI Creative Commons
Yinhan Li,

Xinhui Zou,

Ying Ma

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 289, P. 117643 - 117643

Published: Jan. 1, 2025

The threat posed by light pollution to human health is increasing remarkably. As demand for high-efficiency and bright lighting increases, so does the blue content from artificial sources. Although animal studies suggested induced depression-like behaviors, evidence remained limited, mechanisms which affects depression elusive. This study aimed investigate association between exposure in humans, explored underlying that driving behaviors light. Our population findings showed high-blue-light at night was positively associated with depressive symptoms. Lactic acid relevant Mendelian randomization analysis. Moreover, demonstrated during sleep (BLS) animals. Metabolomics colorimetric analyses revealed elevated levels of lactic cerebrospinal fluid lateral habenula (LHb) rats BLS. administration a lactate inhibitor (Oxamate) alleviated these along changes neuronal excitability, synaptic function, morphology LHb. Overall, our suggests excessive high light-content links increased symptoms, revealing possible molecular prevention strategies, are crucial addressing environmentally related mental issues.

Language: Английский

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