Formation and hazard of ethyl carbamate and construction of genetically engineered Saccharomyces cerevisiae strains in Huangjiu (Chinese grain wine)

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2024, Volume and Issue: 23(2)

Published: March 1, 2024

Abstract Huangjiu , a well‐known conventional fermented Chinese grain wine, is widely consumed in Asia for its distinct flavor. Trace amounts of ethyl carbamate (EC) may be generated during the fermentation or storage process. The International Agency Research on Cancer elevated EC to Class 2A carcinogen, so it necessary regulate content . risk intake dietary mainly assessed through margin exposure (MOE) recommended by European Food Safety Authority, with smaller MOE indicating higher risk. Interventions are reduce formation. As urea, one main precursors formation primarily produced Saccharomyces cerevisiae catabolism arginine, construction dominant engineered strains favorable trend future production and application This review summarized carcinogenic mechanism from perspectives precursor substances, metabolic pathways after ingestion, assessment. methods constructing S. genetic engineering technology were reviewed, which provided an important theoretical basis reducing strengthening practical control safety, research direction was prospected.

Language: Английский

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Metabolomics as a critical tool for deeper understanding of pickled foods: From biomarker discovery to nutrition function

Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: 147, P. 104456 - 104456

Published: March 25, 2024

Language: Английский

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High-confidence structural annotation of substances via multi-layer molecular network reveals the system-wide constituent alternations in milk interfered with diphenylolpropane

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 471, P. 134334 - 134334

Published: April 17, 2024

Language: Английский

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Improving curcumin bioavailability: Targeted delivery of curcumin and loading systems in intestinal inflammation

Food Research International, Journal Year: 2024, Volume and Issue: 196, P. 115079 - 115079

Published: Sept. 14, 2024

Language: Английский

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Molecular docking and transcriptomic analysis reveal the mechanism of myosin-derived peptides activating bitter receptor of hT2R1

Food Bioscience, Journal Year: 2024, Volume and Issue: 62, P. 105067 - 105067

Published: Sept. 7, 2024

Language: Английский

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3D-MPEA: A Graph Attention Model-Guided Computational Approach for Annotating Unknown Metabolites in Interactomics via Mass Spectrometry-Focused Multilayer Molecular Networking

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(19), P. 7532 - 7541

Published: May 3, 2024

The spectral matching strategy of MS2 fragment spectrograms serves as a ubiquitous method for compound characterization within the matrix. Nevertheless, challenges arise due to deficiency distinctions in spectra across instruments caused by coelution peak-derived fragments and incompleteness current reference database, leading dilemma multidimensional omics annotation. graph attention model embedded with long short-term memory was proposed an optimized approach involving integrating similar into molecular networks according isotopic ion peak cluster spacing features collapse diverse species expand library, which efficiently evaluated substance capture capacity 123.1% than classic perception tactics. versatility utility established annotation procedure were showcased study on stimulation pork mediated 2,2-bis(4-hydroxyphenyl)propane enabled global metabolite from knowns unknowns at metabolite-lipid-protein level. On silico extended library search provided group truth, 83.5–117.1% accuracy surpassed 1.2–14.3% precision after manual validation. β-Ala-His dipeptidase first evidenced critical node related transformation α-helical (36.57 35.74%) random coil (41.53 42.36%) 2,2-bis(4-hydroxyphenyl)propane, ultimately triggering augment catalytic performance, inducing series oxidative stress, further intervening availability animal-derived substrates. integration ionic feature models allows effective recurrent organisms deciphering unacquainted matter multiomics.

Language: Английский

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Se-Pair Search for Deciphering Selenium-Encoded Peptide and a Pyrolysis-Thermolysis Dietary Model for Minimizing Loss of “KKSe(M)R” during Processing

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(22), P. 12566 - 12581

Published: May 21, 2024

Dietary deficiency of selenium is a global health hazard. Supplementation organic selenopeptides via food crops relatively safe approach. Selenopeptides with heterogeneous selenium-encoded isotopes or poorly fragmented peptide backbone remain unidentified in site-specific selenoproteomic analysis. Herein, we developed the Se-Pair Search, UniProtKB-FASTA-independent peptide-matching strategy, exploiting fragmentation patterns shared backbones to optimize spectral interpretation, along developing new selenosite assignment schemes (steps 1–3) standardize selenium-localization data reporting for selenoproteome community and thereby facilitating discovery unexpected selenopeptides. Using selenium-biofortified rice under cooking, fermentation, high-temperature high-pressure processing conditions as pyrolysis-thermolysis dietary model, probed single-molecule-level kinetic evolution novel selenopeptide "KKSe(M)R" qual-quantitative information on graph-theory-oriented localization calculations, abundance patterns, activation energy, rate constants at selenoproteome-wide scale. We ground-truth-annotated thirteen products inferred four pathways characterize formation reactivity main intermediate variables KKSe(M)R constructed an advanced probe-type ultrasound technique prior minimizing loss during processing. Importantly, reveal unappreciated pyro-excitation diversion time temperature matrices. These findings provide pioneering theoretical guidance controlling supplementation within safety thresholds.

Language: Английский

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Advanced functional materials as reliable tools for capturing food‐derived peptides to optimize the peptidomics pre‐treatment enrichment workflow

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2024, Volume and Issue: unknown

Published: July 23, 2024

Abstract Peptidomics strategies with high throughput, sensitivity, and reproducibility are key tools for comprehensively analyzing peptide composition potential functional activities in foods. Nevertheless, complex signal interference, limited ionization efficiency, low abundance have impeded food‐derived peptides’ progress food detection analysis. As a result, novel materials been born at the right moment that could eliminate interference perform efficient enrichment. Of note, few studies focused on developing enrichment sample This work summarizes development of endogenous peptide, phosphopeptide, glycopeptide utilizing employed extensively recently: organic framework materials, carbon‐based nanomaterials, bio‐based magnetic molecularly imprinted polymers. It focuses limitations, solutions, future prospects application peptidomics various advanced materials. The size‐exclusion effect adjustable aperture modification material enhanced sensitivity selectivity aided streamlining process cutting down time. Not only that, immobilization metal ions such as Ti 4+ Nb 5+ capture phosphopeptides, introduction hydrophilic groups arginine, L ‐cysteine, glutathione into effectively optimized glycopeptides. Although portion carefully constructed currently exhibit promising applications field analytical chemistry, there is reason to believe they will further advance through improved pre‐treatment steps.

Language: Английский

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Exploring the application of molecular simulation technology in food sector: focusing on food component interactions and food quality

Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105480 - 105480

Published: Nov. 1, 2024

Language: Английский

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Dissecting the binding effect of Crocetin glucosyltransferase 2 in crocetin biotransformation in saffron (Crocus sativus L.) from different origins

Food Chemistry, Journal Year: 2024, Volume and Issue: 455, P. 139917 - 139917

Published: May 31, 2024

Language: Английский

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