Cecal Microbial Diversity and Metabolome Reveal a Reduction in Growth Due to Oxidative Stress Caused by a Low-Energy Diet in Donkeys DOI Creative Commons
L. Li, Xiaoyu Guo,

Yanli Zhao

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(11), P. 1377 - 1377

Published: Nov. 11, 2024

Dietary energy level plays an important role in animal growth and development. The present study investigated the effect of dietary on performance, antioxidative state, nutrient digestion meat donkeys. It simultaneously explored probable reason for cecal microbiota metabolome. Twelve donkeys (male) aged 1 year with a similar weight (150 ± 25 kg) were divided into two treatment groups: low-energy group (E1) high-energy (E2). experiment was 10-day pre-trial period 135-day trial period. Donkeys periods fed diets digestible values (in dry matter) 12.08 13.38 MJ/kg (pre-fattening, 1–45 d), 13.01 14.27 (mid-fattening, 46–90 13.54 14.93 (late-fattening, 91–135 d). results show that E1 decreases body weight, average daily gain (ADG), digestibility crude protein, ether extract, neutral detergent fiber, acid fiber (p < 0.05), but increases acetate butyrate concentrations, non-esterified fatty acids (NEFAs) serum, ratio matter intake to ADG(F/G). diminished activities catalase glutathione peroxidase, while it increased content interleukin, tumor necrosis factor-alpha, reactive oxygen species (ROS) 0.05). Cecal microbiome showed abundance Firmicutes Actinobacteria significantly lower than E2 = 0.029, p 0.002), whereas Bacteroidetes higher 0.005). genera Ruminococcaceae-UCG-004, Acinetobacter, Rikenellaceae_RC9_gut_group. Meanwhile, metabolome formyl-5-hydroxykynurenamine, chorismate, 3-sulfinoalanine, 3-isopropylmalate upregulated E1, brassinolide downregulated. altered metabolites mainly enriched metabolic pathways related metabolism mitigate oxidative stress donkeys, such as tryptophan metabolism, brassinosteroid biosynthesis etc. In conclusion, resulted negative balance resulting more nutrients being oxidized provide energy, inducing stress, thereby leading decreasing growth. reduction donkey from changes cecum metabolites.

Language: Английский

Imperata cylindrica polysaccharide ameliorates intestinal dysbiosis and damage in hyperuricemic nephropathy DOI

Wenchen Yu,

Gang Huang, Junwen Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134432 - 134432

Published: Aug. 7, 2024

Language: Английский

Citations

4
Effects of Artemisia argyi leaf water extract (AWE) on growth performance, muscle quality, intestinal microbial, and metabolomics of common carp (Cyprinus carpio) DOI

Di Sun,

Nanyang Zeng,

Y. Pan

et al.

Aquaculture Reports, Journal Year: 2025, Volume and Issue: 40, P. 102635 - 102635

Published: Jan. 25, 2025

Language: Английский

Citations

0
Advances in Donkey Disease Surveillance and Microbiome Characterization in China DOI Creative Commons
Muhammad Zahoor Khan, Yan Li, Mingxia Zhu

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(4), P. 749 - 749

Published: March 26, 2025

This review article highlights the surveillance of bacterial, viral, and parasitic diseases in donkey populations China. Key findings highlight significant threats from Equine herpesviruses (EHV-8 EHV-1), which cause encephalitis, abortion, respiratory distress. Several infections including Giardia duodenalis, Cryptosporidium spp., Enterocytozoon bieneusi, Toxoplasma gondii present important zoonotic concerns across multiple regions Additionally, this synthesizes current knowledge on microbiota various body sites examines their functional significance health disease. The complex relationship between host represents a critical area research donkeys. Recent molecular advancements have enhanced our understanding diverse microbial ecosystems inhabiting different donkeys profound impact outcomes. As single-stomach herbivores, possess communities throughout digestive tracts that are essential for intestinal homeostasis nutritional processing. Significant variations composition exist segments, with hindgut displaying greater richness diversity compared to foregut. Beyond system, distinct profiles been characterized skin, oral cavity, reproductive tract, secretions such as milk. implications extend areas nutrition, immune function, disease susceptibility. Research demonstrates how dietary interventions, environmental stressors, physiological states significantly alter communities, correlating changes inflammatory markers, antioxidant responses, metabolic functions. specific signatures associated conditions like endometritis suggest potential microbiota-based diagnostics therapeutics. identification antibiotic-resistant strains Proteus mirabilis Klebsiella pneumoniae meat food safety requiring monitoring systems standardized protocols. These provide foundation improved healthcare management, targeted surveillance, protective measures those working or consuming donkey-derived products.

Language: Английский

Citations

0
Cecal Microbial Diversity and Metabolome Reveal a Reduction in Growth Due to Oxidative Stress Caused by a Low-Energy Diet in Donkeys DOI Creative Commons
L. Li, Xiaoyu Guo,

Yanli Zhao

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(11), P. 1377 - 1377

Published: Nov. 11, 2024

Dietary energy level plays an important role in animal growth and development. The present study investigated the effect of dietary on performance, antioxidative state, nutrient digestion meat donkeys. It simultaneously explored probable reason for cecal microbiota metabolome. Twelve donkeys (male) aged 1 year with a similar weight (150 ± 25 kg) were divided into two treatment groups: low-energy group (E1) high-energy (E2). experiment was 10-day pre-trial period 135-day trial period. Donkeys periods fed diets digestible values (in dry matter) 12.08 13.38 MJ/kg (pre-fattening, 1–45 d), 13.01 14.27 (mid-fattening, 46–90 13.54 14.93 (late-fattening, 91–135 d). results show that E1 decreases body weight, average daily gain (ADG), digestibility crude protein, ether extract, neutral detergent fiber, acid fiber (p < 0.05), but increases acetate butyrate concentrations, non-esterified fatty acids (NEFAs) serum, ratio matter intake to ADG(F/G). diminished activities catalase glutathione peroxidase, while it increased content interleukin, tumor necrosis factor-alpha, reactive oxygen species (ROS) 0.05). Cecal microbiome showed abundance Firmicutes Actinobacteria significantly lower than E2 = 0.029, p 0.002), whereas Bacteroidetes higher 0.005). genera Ruminococcaceae-UCG-004, Acinetobacter, Rikenellaceae_RC9_gut_group. Meanwhile, metabolome formyl-5-hydroxykynurenamine, chorismate, 3-sulfinoalanine, 3-isopropylmalate upregulated E1, brassinolide downregulated. altered metabolites mainly enriched metabolic pathways related metabolism mitigate oxidative stress donkeys, such as tryptophan metabolism, brassinosteroid biosynthesis etc. In conclusion, resulted negative balance resulting more nutrients being oxidized provide energy, inducing stress, thereby leading decreasing growth. reduction donkey from changes cecum metabolites.

Language: Английский

Citations

1