Sex differences in the molecular profile of adult diffuse glioma are shaped by IDH status and tumor microenvironment
Neuro-Oncology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 5, 2024
Abstract
Background
Sex
differences
in
adult
diffuse
glioma
(ADG)
are
well
established
clinically,
yet
the
underlying
molecular
mechanisms
remain
inadequately
understood.
Here,
we
aim
to
reveal
features
and
cellular
compositions
unique
each
sex
ADG
comprehend
role
of
disease
etiology.
Methods
We
quantified
transcriptome
using
multiple
independent
patient
datasets.
Next,
delved
into
single-cell
landscape
examine
gene
expression
composition.
To
explore
how
influences
progression,
analyzed
paired
samples
from
primary
recurrent
cases,
aiming
identify
sex-specific
features.
Results
Our
analysis
revealed
that
mutations
isocitrate
dehydrogenase
(IDH)
genes
tumor
microenvironment
emerged
as
influencers
sex-differential
enrichments.
In
IDHwt
tumors,
neuronal
signaling
pathway
found
be
enriched
male
while
hypoxia
inflammatory
response
pathways
female
tumors.
This
pattern
was
reversed
IDHmut
gliomas.
hypothesized
these
distinctions
could
attributed
heterogeneous
composition
between
sexes.
Using
data,
observed
distinctive
patterns
cell
states,
composition,
cell–cell
interaction
tumors
separately.
Further,
by
comparing
changes
samples,
identified
characteristics
Conclusions
results
provide
a
comprehensive
multilevel
characterization
ADG;
such
findings
novel
insights
progression
sex.
Language: Английский
The prognostic significance of androgen receptor expression in gliomas
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Sept. 27, 2024
Androgen
receptor
(AR)
overexpression
has
been
identified
in
gliomas
and
its
stem
cells,
suggesting
that
AR
plays
an
important
role
tumor
carcinogenesis.
The
prognostic
significance
of
remains
unknown.
mRNA
expression
relevant
clinical
data
were
obtained
from
Cancer
Genome
Atlas
Chinese
Glioma
databases.
levels
compared
across
different
histopathologic
grades
molecular
subtypes.
Kaplan-Meier
analyses
patients
with
investigated
for
the
potential
values
AR.
Compared
normal
brain
tissue,
show
significantly
higher
(p
<
0.01).
was
more
prominent
grade
disease
worse
subtypes
protein
is
abundant
glioblastoma
than
lower
(LGG)
(grade
2/3)
0.0001).
This
corroborated
by
a
linear
association
between
(r
=
0.65).
In
LGG,
both
associated
overall
survival
(OS).
Five-year
OS
LGG
high
versus
low
59.1%
73.3%,
respectively
not
within
patients.
Gender
or
prognosis.
Higher
are
features
predicting
poorer
prognosis
gliomas.
gene
correlated
poor
but
cohort
saturated
expression/functions
glioblastoma.
Language: Английский
Impact of Sex Hormones on Glioblastoma: Sex-Related Differences and Neuroradiological Insights
Life,
Journal Year:
2024,
Volume and Issue:
14(12), P. 1523 - 1523
Published: Nov. 21, 2024
Glioblastoma
(GBM)
displays
significant
gender
disparities,
being
1.6
times
more
prevalent
in
men,
with
a
median
survival
time
of
15.0
months
for
males
compared
to
25.5
females.
These
differences
may
be
linked
gonadal
steroid
hormones,
particularly
testosterone,
which
interacts
the
androgen
receptor
(AR)
promote
tumor
proliferation.
Conversely,
estrogen
(E2),
progesterone
(P4),
and
P4
metabolites
exert
complex
effects
on
GBM.
Despite
these
insights,
identification
reliable
hormonal
markers
remains
challenging,
studies
investigating
hormone
therapies
yield
inconclusive
results
due
small
sample
sizes
heterogeneous
histology.
Additionally,
genetic,
epigenetic,
immunological
factors
play
critical
roles
sex
female
patients
demonstrating
increased
O6-Methylguanine-DNA
methyltransferase
promoter
methylation
greater
genomic
instability.
complexities
highlight
need
personalized
therapeutic
strategies
that
integrate
influences
alongside
other
sex-specific
biological
characteristics
management
In
this
review,
we
present
current
understanding
potential
role
hormones
natural
history
Language: Английский