The Diagnostic Significance of Cellular Immune Inflammation Markers in Assessing Different Malignancy Grades Gliomas
Abstract
Purpose.
The
purpose
of
this
study
was
to
evaluate
the
diagnostic
relevance
inflammatory
markers
in
gliomas,
taking
into
account
different
histological
subtypes
and
malignancy
levels.
Methods.
This
prospective
included
139
adult
glioma
patients.
Patients
were
stratified
by
tumour
grade
genetic
mutation,
yielding
25
cases
diffuse
astrocytoma
2,
3
or
4
with
IDH1/2-mutations
89
glioblastoma.
detected
50
patients,
15
which
had
co-deletion
at
1p19q.
pre-operative
neutrophil-lymphocyte
ratio
(NLR),
lymphocyte-monocyte
(LMR)
platelet-lymphocyte
(PLR)
calculated.
Results.
LMR
2
group
higher
than
that
3,
glioblastoma
groups
(3,71
vs
3,09
3;
p
<
0,05)
areas
under
curve
(AUCs)
0,6552
(0,4930-0,8174)
0,6586
(0,5583-0,7590)
respectively.
patients
IDH1/2-mutation
gliomas
(3.44
3.0;
=
0.039).
No
differences
observed
between
oligodendroglioma
(3.43
3.19;
0.76).
all
cohorts
not
affected
use
corticosteroids.
NLR
(2.9
1.96,
0.05).
Increases
neutrophils
correlated
corticosteroids
(3.7
vs.
8.0,
0.05
1.95
3.79,
0.05,
respectively).
Conclusion.
is
a
reliable,
non-corticosteroid
independent
biomarker
for
diagnosing
lower
levels
indicating
tumor
malignancy.
Conversely,
an
unreliable
due
its
elevation,
often
results
from
glucocorticoid
therapy.
Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown
Published: March 26, 2025
Language: Английский