Modulation of the Circadian Rhythm and Oxidative Stress as Molecular Targets to Improve Vascular Dementia: A Pharmacological Perspective

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4401 - 4401

Published: April 16, 2024

The circadian rhythms generated by the master biological clock located in brain's hypothalamus influence central physiological processes. At molecular level, a core set of genes interact to form transcription-translation feedback loops that provide basis rhythm. In animal models disease, desynchronization peripheral tissues with has been detected. Interestingly, patients vascular dementia have sleep disorders and irregular patterns. These alterations impact hormonal levels, cardiovascular health (including blood pressure regulation vessel function), pattern expression activity antioxidant enzymes. Additionally, oxidative stress can arise from ischemia-reperfusion injury, amyloid-beta production, abnormal phosphorylation tau protein, neurotransmitters, among others. Several signaling pathways are involved pathogenesis dementia. While precise mechanisms linking still being studied, there is evidence suggest maintaining healthy patterns supporting proper rhythm function may be important for reducing risk Here, we reviewed main action targets related cycle

Language: Английский

---

Ripening associated antioxidant and phytochemical changes in mango (Mangifera indica) cultivar Dusehri

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 2, 2025

The phytochemical fingerprinting that add to the nutritional and nutraceutical value of fruits during ripening stages is beneficial for human consumption. Therefore, ripening-dependent changes in content antioxidant activities mango (Mangifera indica L.) cultivar Dusehri at various were evaluated. Bioassays phenolic content, flavonoid activities, UHPLC/MS profiling was performed five (RSI-RSV). Total contents significantly increased from 4.25 13.08 µg GAE/mg extract upto stage III non-significant decrease observed thereafter. Flavonoid varied between 1.16 1.23 QE/mg extract. DPPH based free radical scavenging activity (41.07–52.33%) I V while FRSP analysis showed (53.01–27.61 TE/mg extract) V. capacity total reducing power potential pulp gradually towards stages. A change amylase inhibition dropped IV UHPLC depicted aconitic, methylisocitric, 2,4,6-Hydroxy benzoic acid beta glucogallin, poly phenols, 1-Methylxanthine, 3-Furicacid, Heptenoic many others are present different dusehri mango. PCA hierarchal show Stage & II clustering III-V make separate cluster. These phytochemiclas responsible health benefits. study concludes have significant antioxidative due diverse phytochemicals.

Language: Английский

---

Phytochemical Analysis and Biological Activities of Leiotulus aureus Extracts: Antioxidant, Anticholinesterase, Antidiabetic, and Antidepressant Properties

Process Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

---

Exploring the Role of Phenolic Compounds in Chronic Kidney Disease: A Systematic Review

Molecules, Journal Year: 2024, Volume and Issue: 29(11), P. 2576 - 2576

Published: May 30, 2024

Chronic kidney disease (CKD) presents a formidable global health concern, affecting one in six adults over 25. This review explores the potential of phenolic compounds managing CKD and its complications. By examining existing research, we highlight their diverse biological activities to combat CKD-related issues. We analyze nutritional benefits, bioavailability, safety profile these compounds. While clinical evidence is promising, preclinical studies offer valuable insights into underlying mechanisms, optimal dosages, side effects. Further research crucial validate therapeutic efficacy for CKD. advocate continued exploration innovative applications food, pharmaceuticals, nutraceuticals. aims catalyze scientific community's efforts leverage against challenges.

Language: Английский

---

Incorporating white radish extract and L. plantarum to ultra-filtrated soft cheese for boost its functional, microbiological, and sensory qualities

Biocatalysis and Agricultural Biotechnology, Journal Year: 2024, Volume and Issue: 58, P. 103188 - 103188

Published: April 23, 2024

Language: Английский

---

Biotransformation of phytochemicals: Way forward to gut microbial, nutraceuticals and herbal therapeutics advancements

Functional Food Science - Online ISSN 2767-3146, Journal Year: 2024, Volume and Issue: 4(3), P. 96 - 118

Published: March 25, 2024

Mammalian gastrointestinal tract is inhabited by trillions of symbiotic microbiotas representing viruses, bacteria, archaea and eukaryotes including yeasts, fungi protozoa. Compared to humans, the herbivores harbor a complex metabolically efficient microbes which not only detoxify inadvertently consumed anti-nutritional phytochemicals, but also convert ingested tannin-polyphenols, saponins, phytoestrogens alkaloids into metabolites are more available bioactive than their precursors. Some toxicants eliminate them from body. The resulting display range nutritional therapeutic benefits besides direct impact on enhancing diversity functioning gut microbiome. Metabolically active microbiota generated might be futuristic alternative biotherapeutics develop nutraceuticals plant-based health formulations primarily for ‘metabotype 0’ individuals. Further insights novel microbial species, modes biotransformation phytochemicals botanicals will pave way non-antibiotic interventions avert infections boost human veterinary health. Keywords: Gut microbiome; Phytochemicals; Biotransformation; Biotherapeutics Highlights: dietary prevent host against chronic diseases infections. Little known about metabolism action GI herbal supplements. having anti-inflammatory, anti-oxidative anti-carcinogenic properties therapeutics.

Language: Английский

---

Identification of polyphenol composition in grape (Vitis vinifera cv. Bidaneh Sefid) stem using green extraction methods and LC–MS/MS analysis

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(9), P. 6789 - 6798

Published: July 9, 2024

Abstract The utilization of grape stems, a by‐product the processing industry, as source valuable bioactive compounds, particularly polyphenols, has gained attention in recent years. This study aimed to investigate different eco‐friendly extraction methods for obtaining polyphenols from ( Vitis vinifera cv. Bidaneh Sefid) focusing on green solvents and innovative techniques. Four were tested, involving use water polyethylene glycol (PEG) solvents, along with maceration, microwave, ultrasound, reduced‐pressure High‐performance liquid chromatography coupled electrospray ionization tandem mass spectrometry (HPLC–ESI‐MS/MS) was used characterize quantify compounds extracts. A total 29 including phenolic acids, flavonoids, proanthocyanidins, stilbenes, detected. Among four 1 (water + microwave ultrasound atmospheric pressure) 2 reduced found be most effective. Our demonstrated that using PEG combined techniques like pressure, effectively extracted both hydrophobic hydrophilic stems. These findings suggest further exploration these could lead development value‐added products emphasizing significance recovery winemaking by‐products.

Language: Английский

---

Comparative evaluation of phytochemical, in vitro antioxidant activities and elemental composition of the fruit, leaves, and stem bark of Tetrapleura tetraptera

Functional Food Science - Online ISSN 2767-3146, Journal Year: 2023, Volume and Issue: 3(12)

Published: Dec. 26, 2023

Introduction: Nowadays, medicinal plants are widely accepted as a better option than synthetic medications due to their lower cost and little no side effects. The current study aimed compare the elemental composition, phytochemical profile, antioxidant efficacy of n-hexane extracts derived from Tetrapleura tetraptera fruit, stem bark, leaves. Methods: fresh fruits, leaves, bark plant were collected dried. dried samples pulverized exhaustively extracted with n-hexane. screened for both qualitative quantitative constituents. Antioxidant parameters such Ferric Reducing Property (FRAP) 2,2-Diphenyl-1-picryl hydroxyl radical scavenging activity (DPPH) also carried out. analysis various organs was evaluated using standard protocols. Results: presence alkaloids, flavonoids, tannins, saponins, terpenes, resins, phenolswas revealed in data. T. has higher concentrations alkaloids flavonoids leaf according examination elements plant. had highest Total Phenolic Content at 1000 µg/mL, whereas leaves lowest TPC 200 µg/mL.At concentration exhibited greatest total flavonoid (TFC) extracts, followed by fruits At µg/mL concentration, FRAP test maximum bark. Generally speaking, when rises, so do TPC, TFC, activities. Compared ascorbic acid (2.76 µg/mL), level DPPH activity, an IC 50 13.34 µg/mL. that Ca, Mg, Fe, fruit order.Conclusion: This research result established plant, T can be standardized offer alternative eco-friendly drug immunity building. barks underutilized, however, its studies other investigations pointed potential cosmeceutical industries medicine. Keywords: ethnomedicine, ferric-reducing assay,

Language: Английский

---

The investigation of bioactive compounds in the Charentsi grape variety and its derived wines

Bioactive Compounds in Health and Disease - Online ISSN 2574-0334 Print ISSN 2769-2426, Journal Year: 2023, Volume and Issue: 6(11), P. 303 - 303

Published: Nov. 24, 2023

Background: Grapes contain thousands of chemical compounds, including sugars, organic acids, phenolic minerals, nitrogen, amino and aromatic compounds.Objectives: The study investigates the possibility producing high-quality red wines from Charentsi grape variety observes extraction bioactive compounds formed during fermentation.Results: acids in grapes wine were also studied. There significant differences mentioned above between samples based on yeasts used. Our observations showed that amount tartaric acid was 7.26 g/l, after fermentation by using different samples, content was: BSC:103 2.06 AC-4: 1.79 g/l. sample contained 3.01g/l malic acid, while selections BCS103 AC-4 2.01g/l 3.00g/l, respectively. In case citric 0.5 g/l a, with 0.52 0.57 respectively.The did not lactic or succinic acid. Wine fermented a newly yeasts. yeast, these values 1.89 1.63 1.3 1.61 AC-4.The anthocyanin flavonoids are 2084.5 mg/kg 8828.6 mg/kg, high quantities as well. concentrations BCS103, 842.7 mg/l 4898.22 mg/l, they 783.3 5025.5 AC-4. total detected 4957.9 5102.6 According to analysis, 37%-40% 55-56% transferred wine.Conclusion: highly functional due their acids. These biologically active influenced yeast strain used for fermentation.Keywords: grapes, wine,

Language: Английский

---

Effect of prebiotics, probiotics, and synbiotics on gut microbiome in diabetes among coastal communities

Functional Food Science - Online ISSN 2767-3146, Journal Year: 2024, Volume and Issue: 4(1), P. 11 - 11

Published: Jan. 8, 2024

Cutting-edge research on oceans and human health is enhancing our comprehension of disease-causing organisms in coastal ecosystems. Coastal areas are affected by pollution resulting from the changes hydrology land utilization. In population, an elevated incidence diabetes was observed. Diabetes mellitus a prominent metabolic disease that causing major burdens for patients as well physicians. intricate condition encompasses several molecular pathways associated with gut microbiome. The microbiome significantly influences permeability gastrointestinal mucosa. Alterations wide range microbiomes have been various issues including diabetes. two contributors to type 2 insulin resistance inflammation which may result dysregulation due dysbiosis. Due dysbiosis, show high prevalence individuals living areas. correlation between dysbiosis can be made, especially considering probiotics demonstrated some impact helping diabetic their interrupted metabolism revert normal. Probiotic intake has reportedly resulted improved control among Prebiotics non-digestible carbohydrates naturally extracted or synthetically produced. Uses synbiotics synergistic altering environment. communities, potential effects probiotic, prebiotic, synbiotic therapy investigated. Although these therapies encouraging results areas, more needed fully understand implications controlling this setting. review, we describe role residing regions underlying mechanisms existed analysing predicting function people. pre, pro, 1 precisely summarized. Keywords: Type diabetes, microbiome, region, prebiotics, synbiotics, probiotics.

Language: Английский

---