Epidemiology and molecular characteristics of respiratory syncytial virus (RSV) among italian community-dwelling adults, 2021/22 season DOI Creative Commons
Donatella Panatto, Alexander Domnich, Piero Luigi Lai

et al.

BMC Infectious Diseases, Journal Year: 2023, Volume and Issue: 23(1)

Published: March 7, 2023

Respiratory syncytial virus (RSV) is a leading cause of acute respiratory infections worldwide. While historically RSV research has been focused on children, data infection in adults are limited. The goal this study was to establish the prevalence community-dwelling Italian and analyze its genetic variability during 2021/22 winter season.In cross-sectional study, random sample naso-/oropharyngeal specimens from symptomatic seeking for SARS-CoV-2 molecular testing between December 2021 March 2022 were tested other pathogens by means reverse-transcription polymerase chain reaction. RSV-positive samples further molecularly characterized sequence analysis.Of 1,213 tested, 1.6% (95% CI: 0.9-2.4%) positive subgroups A (44.4%) B (55.6%) identified similar proportions. epidemic peak occurred 2021, when as high 4.6% 2.2-8.3%). detection (p = 0.64) that influenza (1.9%). All strains belonged ON1 BA genotypes, respectively. Most (72.2%) also being SARS-CoV-2, Streptococcus pneumoniae rhinovirus most frequent. load significantly higher among mono-detections than co-detections.During season, predominant circulation some non-pharmaceutical containment measures still place, substantial proportion genetically diversified both subtypes. In view upcoming registration vaccines, establishment National surveillance system urgently needed.

Language: Английский

The effects of the COVID-19 pandemic on community respiratory virus activity DOI Open Access
Eric J. Chow, Timothy M. Uyeki, Helen Y. Chu

et al.

Nature Reviews Microbiology, Journal Year: 2022, Volume and Issue: unknown

Published: Oct. 17, 2022

Language: Английский

Citations

473
Municipal and neighbourhood level wastewater surveillance and subtyping of an influenza virus outbreak DOI Creative Commons
Élisabeth Mercier, Patrick M. D’Aoust, Ocean Thakali

et al.

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: Sept. 22, 2022

Recurrent influenza epidemics and pandemic potential are significant risks to global health. Public health authorities use clinical surveillance locate monitor influenza-like cases outbreaks mitigate hospitalizations deaths. Currently, integration of is the only reliable method for reporting types subtypes warn emergent strains. The utility wastewater (WWS) during COVID-19 as a less resource intensive replacement or complement has been predicated on analyzing viral fragments in wastewater. We show here that virus targets stable partitions favorably solids fraction. By quantifying, typing, subtyping municipal primary sludge community outbreak, we forecasted citywide flu outbreak with 17-day lead time provided population-level near real-time feasibility WWS at neighbourhood levels real using minimal resources infrastructure.

Language: Английский

Citations

110
Why has the epidemiology of RSV changed during the COVID-19 pandemic? DOI Creative Commons
Bahaa Abu-Raya, Marina Viñeta Paramo,

Frederic Reicherz

et al.

EClinicalMedicine, Journal Year: 2023, Volume and Issue: 61, P. 102089 - 102089

Published: July 1, 2023

The coronavirus disease 2019 (COVID-19) pandemic has drastically perturbed the epidemiology of Respiratory Syncytial Virus (RSV) respiratory tract infections in children. reasons for this are not clear. In article, we review current literature and critically discuss different theories to explain why RSV changed during COVID-19 pandemic. Proposed mechanisms include decreased viral immunity vulnerable age groups caused by prolonged lack circulation early pandemic, potential Severe Acute Syndrome Corona 2 (SARS-CoV-2)-induced immune dysregulation, interactions between SARS-CoV-2 RSV, modifications health-seeking behaviors as well heath systems factors. Research genomics phylogeny, more robust immunology research is needed guide prevention health care resource planning.

Language: Английский

Citations

109
Infection and co-infection patterns of community-acquired pneumonia in patients of different ages in China from 2009 to 2020: a national surveillance study DOI Creative Commons
Yanning Liu,

Yun-Fa Zhang,

Qiang Xu

et al.

The Lancet Microbe, Journal Year: 2023, Volume and Issue: 4(5), P. e330 - e339

Published: March 28, 2023

Language: Английский

Citations

101
Preparing for uncertainty: endemic paediatric viral illnesses after COVID-19 pandemic disruption DOI
Kevin Messacar, Rachel E. Baker, Sang Woo Park

et al.

The Lancet, Journal Year: 2022, Volume and Issue: 400(10364), P. 1663 - 1665

Published: July 14, 2022

Language: Английский

Citations

91
Global analysis of respiratory viral circulation and timing of epidemics in the pre–COVID-19 and COVID-19 pandemic eras, based on data from the Global Influenza Surveillance and Response System (GISRS) DOI Creative Commons
Marco Del Riccio, Saverio Caini, Guglielmo Bonaccorsi

et al.

International Journal of Infectious Diseases, Journal Year: 2024, Volume and Issue: 144, P. 107052 - 107052

Published: April 17, 2024

Language: Английский

Citations

20
Pathogenesis of influenza and SARS-CoV-2 co-infection at the extremes of age: decipher the ominous tales of immune vulnerability DOI Creative Commons

Kailin Mai,

Weiqi Pan,

Zhengshi Lin

et al.

Advanced Biotechnology, Journal Year: 2025, Volume and Issue: 3(1)

Published: Jan. 21, 2025

The co-circulation of influenza and SARS-CoV-2 has led to co-infection events, primarily affecting children older adults, who are at higher risk for severe disease. Although prevalence is relatively low, it associated with worse outcomes compared mono-infections. Previous studies have shown that the depend on multiple factors, including viral interference, virus-host interaction host response. Children elderly exhibit distinct patterns antiviral response, which involve airway epithelium, mucociliary clearance, innate adaptive immune cells, inflammatory mediators. This review explores pathogeneses co-infection, focusing responses in elderly. By comparing immature immunity senescence we aim provide insights clinical management cases.

Language: Английский

Citations

2
Rapid and quantitative detection of respiratory viruses using surface-enhanced Raman spectroscopy and machine learning DOI
Yanjun Yang, Beibei Xu, Jackelyn Murray

et al.

Biosensors and Bioelectronics, Journal Year: 2022, Volume and Issue: 217, P. 114721 - 114721

Published: Sept. 15, 2022

Language: Английский

Citations

65
The Role of Psychological Factors and Vaccine Conspiracy Beliefs in Influenza Vaccine Hesitancy and Uptake among Jordanian Healthcare Workers during the COVID-19 Pandemic DOI Creative Commons
Malik Sallam, Ramy Mohamed Ghazy,

Khaled Al‐Salahat

et al.

Vaccines, Journal Year: 2022, Volume and Issue: 10(8), P. 1355 - 1355

Published: Aug. 19, 2022

Vaccination to prevent influenza virus infection and lessen its severity is recommended among healthcare workers (HCWs). Health professionals have a higher risk of exposure viruses could transmit the vulnerable patients who are prone severe disease mortality. The aim current study was evaluate levels vaccine acceptance uptake as well determinants, Jordanian HCWs over last season 2021/2022. This based on self-administered electronic survey that distributed in March 2022. Psychological determinants conspiracy beliefs were assessed using previously validated 5C scale questionnaire (confidence, complacency, constraints, calculation collective responsibility) scale. sample comprised total 1218 HCWs: nurses (n = 412, 33.8%), physicians 367, 30.1%), medical technicians 182, 14.9%), pharmacists 161, 13.2%) dentists 87, 7.1%), others. About two-thirds expressed willingness receive vaccination if provided free charge 807, 66.3%), whereas less than one-third willing pay for 388, 31.9%). self-reported 62.8%. following factors significantly associated with freely, opposed hesitancy/rejection: male sex; HCW categories; confidence responsibility; lower constraints calculation. Higher correlated categories, older age, monthly income, responsibility, complacency embrace general beliefs. results can provide helpful clues improve coverage Jordan. Consequently, this help protect patient groups reserve valuable resources settings. appeared be most significant uptake, rates which should considered educational interventional measures aiming promote vaccination.

Language: Английский

Citations

63
Influenza A(H1N1)pdm09 Virus but Not Respiratory Syncytial Virus Interferes with SARS-CoV-2 Replication during Sequential Infections in Human Nasal Epithelial Cells DOI Creative Commons

Clément Fage,

Mathilde Hénaut,

Julie Carbonneau

et al.

Viruses, Journal Year: 2022, Volume and Issue: 14(2), P. 395 - 395

Published: Feb. 15, 2022

The types of interactions between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other viruses are not well-characterized due to the low number co-infection cases described since onset pandemic. We have evaluated SARS-CoV-2 (D614G mutant) influenza A(H1N1)pdm09 or syncytial virus (RSV) in nasal human airway epithelium (HAE) infected simultaneously sequentially (24 h apart) with combinations. replication kinetics each were determined by RT-qPCR at different post-infection times. Our results showed that during simultaneous infection, interferes RSV-A2 but replication. prior infection HAE reduces both viruses. is decreased a RSV-A2. pretreatment BX795, TANK-binding kinase 1 inhibitor, partially alleviates reduced sequential Thus, RSV-A2, whereas only subsequent SARS-CoV-2. mechanism involved viral interference mediated production interferon.

Language: Английский

Citations

39