Seroprevalence of SARS-CoV-2 IgG antibodies in children seeking medical care in Seattle, WA June 2020 to December 2022

Microbiology Spectrum, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

ABSTRACT Seroprevalence studies play an important role in estimating the number of children infected with SARS-CoV-2. We report SARS-CoV-2 seroprevalence seeking medical care for any reason at a free-standing pediatric hospital Seattle, WA over 2.5-year period and four distinct pandemic waves. randomly selected residual serum samples from young adults as inpatients outpatients Seattle Children’s Hospital between June 2020 December 2022 to test presence anti-nucleocapsid (N) antibodies. Samples were categorized into waves based on Washington State epidemiology: Wave 1 (June 2020–October 2020), 2 (November 2020–June 2021), 3 (July 2021–November 4 (December 2021–December 2022). Patient characteristics COVID-19 vaccine status obtained, zip codes used ascertain Social Vulnerability Index (SVI). Multivariable Poisson regression models robust variance estimates examine relationship patient anti-N-positivity each wave. Among 8,040 7,102 patients included analyses, rose 2.4% (95% CI, 2.0%–3.1%) 25.5% CI 23.3%–27.8%) (following Omicron surge). High SVI, Hispanic ethnicity, or use government insurance was associated increased anti-N positivity most observed steady increase followed by sharp after surge early 2022. Our data demonstrate burden specific groups health disparities within our region throughout pandemic. IMPORTANCE results highlight importance seropositivity essential tools provide information incidence prevalence seropositivity. also reinforce other reports demonstrating inequitable that this continued persist pandemic, even high adherence mitigation efforts. It highlights SVI’s value identifying communities must be part research, public vaccination strategies.

Language: Английский

Temporal patterns of asymptomatic SARS‐CoV‐2 infection among pediatric population in Japan: A 3‐year analysis

Journal of Medical Virology, Journal Year: 2024, Volume and Issue: 96(8)

Published: Aug. 1, 2024

To elucidate the seroprevalence and rate of asymptomatic infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Japanese children, serological analysis was performed using serum samples collected from March 2020 to February 2023. A total 1493 were during first study period (March 2021). None positive for SARS-CoV-2 antibody. In second 2021 2022), seven 1055 patients (0.7%) experienced infection. The third 2022 2023) divided into three terms: June 30, 2022; July October November gradually increased throughout this period, rates 6.0%, 18.6%, 30.4% terms, respectively. Pediatric cases occurred after surge Omicron variants. Since none antibody-positive had a previous history disease 2019, may represent

Language: Английский