Activation of the muscle-to-brain axis ameliorates neurocognitive deficits in an Alzheimer disease mouse model via enhancing neurotrophic and synaptic signaling DOI Creative Commons

Hash Brown Taha,

Allison Birnbaum, Ian Matthews

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 16, 2024

Abstract INTRODUCTION Skeletal muscle regulates central nervous system (CNS) function and health, activating the muscle-to-brain axis through secretion of skeletal originating factors (‘myokines’) with neuroprotective properties. However, precise mechanisms underlying these benefits in context Alzheimer’s disease (AD) remain poorly understood. METHODS To investigate signaling response to amyloid β (Aβ)- induced toxicity, we generated 5xFAD transgenic female mice enhanced (5xFAD;cTFEB;HSACre) at prodromal (4-months old) late (8-months symptomatic stages. RESULTS TFEB overexpression reduced Aβ plaque accumulation cortex hippocampus both ages rescued behavioral neurocognitive deficits 8- months-old mice. These changes were associated transcriptional protein remodeling neurotrophic synaptic integrity, partially due CNS-targeting myokine prosaposin (PSAP). DISCUSSION Our findings implicate as a novel pathway against pathogenesis AD.

Language: Английский

Exercise training alleviates symptoms and cognitive decline in a reserpine-induced fibromyalgia model by activating hippocampal PGC-1α/FNDC5/BDNF pathway DOI
Muaz Belviranlı, Nilsel Okudan,

Tuğba Sezer

et al.

Neuroscience, Journal Year: 2024, Volume and Issue: 549, P. 145 - 155

Published: May 15, 2024

Language: Английский

Citations

2
Activation of the muscle-to-brain axis ameliorates neurocognitive deficits in an Alzheimer’s disease mouse model via enhancing neurotrophic and synaptic signaling DOI Creative Commons

Hash Brown Taha,

Allison Birnbaum, Ian Matthews

et al.

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 13, 2024

Language: Английский

Citations

2
Activation of the muscle-to-brain axis ameliorates neurocognitive deficits in an Alzheimer disease mouse model via enhancing neurotrophic and synaptic signaling DOI Creative Commons

Hash Brown Taha,

Allison Birnbaum, Ian Matthews

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 16, 2024

Abstract INTRODUCTION Skeletal muscle regulates central nervous system (CNS) function and health, activating the muscle-to-brain axis through secretion of skeletal originating factors (‘myokines’) with neuroprotective properties. However, precise mechanisms underlying these benefits in context Alzheimer’s disease (AD) remain poorly understood. METHODS To investigate signaling response to amyloid β (Aβ)- induced toxicity, we generated 5xFAD transgenic female mice enhanced (5xFAD;cTFEB;HSACre) at prodromal (4-months old) late (8-months symptomatic stages. RESULTS TFEB overexpression reduced Aβ plaque accumulation cortex hippocampus both ages rescued behavioral neurocognitive deficits 8- months-old mice. These changes were associated transcriptional protein remodeling neurotrophic synaptic integrity, partially due CNS-targeting myokine prosaposin (PSAP). DISCUSSION Our findings implicate as a novel pathway against pathogenesis AD.

Language: Английский

Citations

1