Identifying Serum Small Extracellular Vesicle MicroRNA as a Noninvasive Diagnostic and Prognostic Biomarker for Ovarian Cancer

ACS Nano, Journal Year: 2023, Volume and Issue: 17(19), P. 19197 - 19210

Published: Sept. 26, 2023

There remains a lack of effective and noninvasive methods for the diagnosis prognosis prediction epithelial ovarian carcinoma (EOC). Here, we investigated possibility serum-derived small extracellular vesicle (sEV) microRNAs (miRNAs) as potential biomarkers distinguishing between benign malignant adnexal masses predicting EOC patients. A serum sEV miRNA model identifying (sEVmiR-EOC) was successfully established in training cohort. Furthermore, sEVmiR-EOC confirmed testing cohort validation cohort, demonstrating robust diagnostic accuracy. The showed better performance than carbohydrate antigen 125 (CA125) discriminating patients with stage I from Using samples follow-up data, identified miR-141-3p miR-200c-3p prognostic predictors. Finally, change RiskScore preoperative postoperative found that could predict

Language: Английский

Parasites revive hope for cancer therapy

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: Oct. 5, 2024

Language: Английский

Serum metabolic fingerprints encode functional biomarkers for ovarian cancer diagnosis: a large-scale cohort study

EBioMedicine, Journal Year: 2025, Volume and Issue: 115, P. 105706 - 105706

Published: April 23, 2025

Language: Английский