FK506-binding proteins: Emerging target and therapeutic opportunity in multiple tumors DOI Creative Commons
Hang Ke, Zihan Chen, Long Chen

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141914 - 141914

Published: March 1, 2025

The FK506-binding protein (FKBP) family plays a key role in variety of tumors and is involved the regulation important signaling pathways including AKT, NF-κB p53, which affects cell proliferation, migration, multiple death modes. Here, we summarize findings that different FKBP members exhibit dual functions promoting or inhibiting tumorigenesis types tumors. expression levels are closely related to prognosis patients, thus might be used as potential diagnostic prognostic biomarkers. In future, it necessary combine single-cell sequencing resolve spatial distribution isoforms, develop clinical validation promote translation from molecular mechanism precision therapy.

Language: Английский

FK506-binding proteins: Emerging target and therapeutic opportunity in multiple tumors DOI Creative Commons
Hang Ke, Zihan Chen, Long Chen

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141914 - 141914

Published: March 1, 2025

The FK506-binding protein (FKBP) family plays a key role in variety of tumors and is involved the regulation important signaling pathways including AKT, NF-κB p53, which affects cell proliferation, migration, multiple death modes. Here, we summarize findings that different FKBP members exhibit dual functions promoting or inhibiting tumorigenesis types tumors. expression levels are closely related to prognosis patients, thus might be used as potential diagnostic prognostic biomarkers. In future, it necessary combine single-cell sequencing resolve spatial distribution isoforms, develop clinical validation promote translation from molecular mechanism precision therapy.

Language: Английский

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