The Emerging Role of Photobiomodulation in COVID-19 Therapy Part II DOI Open Access
Richard Williams

Medical Research Archives, Journal Year: 2023, Volume and Issue: 11(8)

Published: Jan. 1, 2023

Purpose: To empirically confirm the utility of photobiomodulation (PBM) in treatment acute and long COVID-19 guided by a mechanistic analysis photochemical effects pulsed light on SARS-CoV-2 infections disease progression. Background: comprises coronavirus severe inflammatory infecting tissue populated ACE-2 receptors upper lower respiratory tract AEC causing an overexpression pro-inflammatory cytokines. Once lungs, viremic spread cytokine profusion progresses into multi-organ hyperinflammation visceral epithelium, vascular endothelium, neurons CNS, PNS, ANS, brain with long-term sequelae. In response to oxidative state, red NIR PBM down-regulates proinflammatory cytokines, activating M2 macrophages Th2 helper cells increase anti-inflammatory immune accordance biphasic dose response. Published reports efficacious therapy using conformal LED pads or scanned lasers. Results: A series two COVID case studies comprising 69 ambulatory (stage 1-to-5) five stage-6 hospitalized patients impact whole-organ deep-tissue algorithmically-pulsed pad optical delivery methods. Together, symptomatic recovery from 64-84 min sessions occurred within three days for 62/62 patients. Full four all (all but cases resolved one week). Prophylactic benefits were recorded 17/17 asymptomatic-to-mild 0-1) exposed viral shedding infected family members. outcomes include total resolution dyspnea, ability maintain SpO2 above 97% without oxygen supplementation, relief digestive distress, elimination fog, improved memory recall, restored executive function, symptomatically managing emotional deficits. Total treatments date comprise approximately three-hundred fifty 60% COVID-19, 20% metabolic COVID, neurological COVID. Unresolved totaling 0.25% anxiety nosophobia where was found deliver only short-term palliative relief. Conclusion: Ongoing results increasingly support application deep COVID-19. Both scanning lasers demonstrate favorable outcomes. higher fluences than same session times. Further prophylactic are indicated.

Language: Английский

New perspectives on the glymphatic system and the relationship between glymphatic system and neurodegenerative diseases DOI Creative Commons
Yujie Sun,

Qiankun Lv,

Junyi Liu

et al.

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: 205, P. 106791 - 106791

Published: Jan. 6, 2025

Neurodegenerative diseases (ND) are characterized by the accumulation of aggregated proteins. The glymphatic system, through its rapid exchange mechanisms between cerebrospinal fluid (CSF) and interstitial (ISF), facilitates movement metabolic substances within brain, serving functions akin to those peripheral lymphatic system. This emerging waste clearance mechanism offers a novel perspective on removal pathological in ND. article elucidates recent discoveries regarding system updates relevant concepts model. It discusses potential roles ND, including Alzheimer's disease (AD), Parkinson's (PD), multiple atrophy (MSA), proposes as therapeutic target for these conditions.

Language: Английский

Citations

2
The anti-inflammatory effects of photobiomodulation are mediated by cytokines: Evidence from a mouse model of inflammation DOI Creative Commons
Shirin Shamloo,

Erwin B. Defensor,

Peter Ciari

et al.

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: April 6, 2023

There is an urgent need for therapeutic approaches that can prevent or limit neuroinflammatory processes and neuronal degeneration. Photobiomodulation (PBM), the use of specific wavelengths light, a safe approach shown to have anti-inflammatory effects. The current study was aimed at evaluating effects PBM on LPS-induced peripheral central inflammation in mice assess its potential as treatment. Daily, 30-min treatment with red/NIR light (RL) RL 40 Hz gamma frequency flicker 10 days prior LPS challenge showed brain systemically. downregulated induction key proinflammatory cytokines associated inflammasome activation, IL-1β IL-18, upregulated cytokine, IL-10. provided robust effects, addition potentiated these Overall, results demonstrate acts through cytokine expression modulation.

Language: Английский

Citations

27
Photobiomodulation in experimental models of Alzheimer’s disease: state-of-the-art and translational perspectives DOI Creative Commons
Zhihai Huang, Michael R. Hamblin, Quanguang Zhang

et al.

Alzheimer s Research & Therapy, Journal Year: 2024, Volume and Issue: 16(1)

Published: May 21, 2024

Abstract Alzheimer’s disease (AD) poses a significant public health problem, affecting millions of people across the world. Despite decades research into therapeutic strategies for AD, effective prevention or treatment this devastating disorder remains elusive. In review, we discuss potential photobiomodulation (PBM) preventing and alleviating AD-associated pathologies, with focus on biological mechanisms underlying therapy. Future directions guidance clinical practice non-invasive non-pharmacological therapy are also highlighted. The available evidence indicates that different paradigms, including transcranial systemic PBM, along recently proposed remote all could be promising AD. PBM exerts diverse effects, such as enhancing mitochondrial function, mitigating neuroinflammation caused by activated glial cells, increasing cerebral perfusion, improving glymphatic drainage, regulating gut microbiome, boosting myokine production, modulating immune system. We suggest may serve powerful intervention

Language: Английский

Citations

10
Unlocking the potential of photobiomodulation therapy for brain neurovascular coupling: The biological effects and medical applications DOI
Bingzi Yan, Jie Zhou, F. Yan

et al.

Journal of Cerebral Blood Flow & Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Photobiomodulation (PBM) therapy stands as an innovative neurostimulation modality that has demonstrated both efficacy and safety in improving brain function. This exerts multifaceted influences on neurons, blood vessels, their intricate interplay known neurovascular coupling (NVC). Growing evidence indicates NVC may present a promising target for PBM intervention. However, the detailed mechanisms underlying its therapeutic benefits remain to be fully understood. review aims elucidate potential metabolic pathways signaling cascades involved modulatory effects of PBM, while also exploring extensive repertoire applications neurologic psychiatric conditions. The prospects within realm investigation are intensively considered, providing deeper insights into powerful capabilities revolutionize treatments.

Language: Английский

Citations

1
The effect of photobiomodulation on the brain during wakefulness and sleep DOI Creative Commons

Cécile Moro,

Audrey Valverde, Marjorie Dole

et al.

Frontiers in Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: July 28, 2022

Over the last seventy years or so, many previous studies have shown that photobiomodulation, use of red to near infrared light on body tissues, can improve central and peripheral neuronal function survival in both health disease. These improvements are thought arise principally from an impact photobiomodulation mitochondrial non-mitochondrial mechanisms a range different cell types, including neurones. This has downstream effects stimulatory protective genes. An often-neglected feature nearly all these is they been induced during state wakefulness. Recent when applied sleep, also be benefit, but way, by improving flow cerebrospinal fluid clearance toxic waste-products brain. In this review, we consider potential differential dependent arousal. We speculate cells systems depending whether it wakefulness may follow circadian rhythm. further arousal-dependent mediated through biophoton – ultra-weak emission network communication repair across

Language: Английский

Citations

35
Activation of testosterone‐androgen receptor mediates cerebrovascular protection by photobiomodulation treatment in photothrombosis‐induced stroke rats DOI Creative Commons
Yu Feng, Zhihai Huang,

Xiaohui Ma

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(2)

Published: Feb. 1, 2024

Numerous epidemiological studies have reported a link between low testosterone levels and an increased risk of cerebrovascular disease in men. However, there is ongoing controversy surrounding replacement therapy due to potential side effects. PBMT has been demonstrated improve function promote synthesis peripheral tissues. Despite this, the molecular mechanisms that could connect with vascular brain photothrombosis (PT)-induced stroke rats remain largely unknown.

Language: Английский

Citations

5
Recent Mechanisms of Neurodegeneration and Photobiomodulation in the Context of Alzheimer’s Disease DOI Open Access
Matthew P. Su, Damir Nizamutdinov, Hanli Liu

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(11), P. 9272 - 9272

Published: May 25, 2023

Alzheimer’s disease (AD) is a neurodegenerative and the world’s primary cause of dementia, condition characterized by significant progressive declines in memory intellectual capacities. While dementia main symptom Alzheimer’s, presents with many other debilitating symptoms, currently, there no known treatment exists to stop its irreversible progression or cure disease. Photobiomodulation has emerged as very promising for improving brain function, using light range from red near-infrared spectrum depending on application, tissue penetration, density target area. The goal this comprehensive review discuss most recent achievements mechanisms AD pathogenesis respect neurodegeneration. It also provides an overview photobiomodulation associated pathology benefits transcranial potential therapeutic solution. This discusses older reports hypotheses development AD, well some approved drugs.

Language: Английский

Citations

13
Effectiveness of non-pharmacological therapies on cognitive function in patients with dementia—A network meta-analysis of randomized controlled trials DOI Creative Commons

Guangxin Luo,

Zhang Junqiu,

Ze-Yi Song

et al.

Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 15

Published: March 2, 2023

Non-pharmacological therapies (NPTs) have received increasing attention from researchers as a category of treatment to improve cognitive impairment in patients with dementia because their fewer side effects. In this study, photobiomodulation (PBM), enriched environment (EE), exercise therapy (ET), computerized training (CCT), and stimulation (CST) were selected compare the effects NPTs that by quantifying information randomized controlled trials (RCTs).We did systematic review network meta-analysis. We searched PubMed, Embase, Cochrane Central Register Controlled Trials (CENTRAL), China National Knowledge Infrastructure Database, Wan Fang Chinese Biomedical Literature Web Science, VIP Database time database creation 1 August 2022. Two investigators independently screened literature, extracted information, assessed RCTs' quality Collaboration Network Risk Bias 2.0. meta-analysis was performed using R language (X64 version 4.1.3) STATA 17.0.We identified 1,268 citations these included 38 comprising 3,412 participants. For improving dementia, results showed compared control group (CON), PBM (SMD = 0.90, 95% CI: 0.43-1.37), EE 0.71, 0.02-1.41), ET 0.42, 0.16-0.68), CST 0.36, 0.11-0.62) significantly different (P < 0.05); There no significant difference CCT 0.41, -0.07-0.88) > 0.05). The ranked has more potential be best intervention 0.90). addition, there between function 0.54, 0.00; 1.08, P 0.05).In excellent cognition people may benefits than other four NPTs.https://www.crd.york.ac.uk/prospero/, identifier CRD42022363746.

Language: Английский

Citations

12
Photobiomodulation for Hypertension and Alzheimer’s Disease DOI Creative Commons
Audrey Valverde, John Mitrofanis

Journal of Alzheimer s Disease, Journal Year: 2022, Volume and Issue: 90(3), P. 1045 - 1055

Published: Sept. 30, 2022

Although the cause(s) of Alzheimer's disease in majority cases remains elusive, it has long been associated with hypertension. In animal models disease, hypertension shown to exacerbate Alzheimer-like pathology and behavior, while humans, during mid-life increases risk developing later life. Unfortunately, once individuals are diagnosed there few therapeutic options available. There is neither an effective symptomatic treatment, one that treats debilitating cognitive memory deficits, nor, more importantly, a neuroprotective stops relentless progression pathology. Further, no specific preventative treatment offsets onset disease. A key factor or clue this quest for may lie contribution review, we explore idea photobiomodulation, application wavelengths light onto body tissues, can reduce neuropathology behavioral deficits by controlling We suggest photobiomodulation be option neurodegenerative

Language: Английский

Citations

19
Use of 31P magnetisation transfer magnetic resonance spectroscopy to measure ATP changes after 670 nm transcranial photobiomodulation in older adults DOI Creative Commons
Elizabeth J. Fear,

Frida H. Torkelsen,

Elisa Zamboni

et al.

Aging Cell, Journal Year: 2023, Volume and Issue: 22(11)

Published: Oct. 6, 2023

Abstract Mitochondrial function declines with age, and many pathological processes in neurodegenerative diseases stem from this dysfunction when mitochondria fail to produce the necessary energy required. Photobiomodulation (PBM), long‐wavelength light therapy, has been shown rescue mitochondrial animal models improve human health, but clinical uptake is limited due uncertainty around efficacy mechanisms responsible. Using 31 P magnetisation transfer magnetic resonance spectroscopy (MT‐MRS) we quantify, for first time, effects of 670 nm PBM treatment on healthy ageing brains. We find a significant increase rate ATP synthase flux brain after cohort older adults. Our study provides initial evidence therapeutic improving restoring recognises that wider studies are now required confirm any resultant cognitive benefits.

Language: Английский

Citations

11