Aryl hydrocarbon receptor impairs circadian regulation in Alzheimer's disease: Potential impact on glymphatic system dysfunction DOI
Antero Salminen

European Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 60(2), P. 3901 - 3920

Published: June 25, 2024

Circadian clocks maintain diurnal rhythms of sleep-wake cycle 24 h that regulate not only the metabolism an organism but also many other periodical processes. There is substantial evidence circadian regulation impaired in Alzheimer's disease. properties known to be disturbed patients, such as integrity blood-brain barrier (BBB) well glymphatic flow controls waste clearance from brain. Interestingly, evolutionarily conserved transcription factor, is, aryl hydrocarbon receptor (AhR), impairs function core clock proteins and thus could disturb rhythmicity BBB. abundant activation AhR signalling inhibits expression major proteins, brain muscle arnt-like 1 (BMAL1), regulator (CLOCK) period (PER1) different experimental models. The robustly increased brains protein level enriched astrocytes It seems since it (i) BBB, which cooperatively interconnected with system brain, (ii) neuroinflammation dysbiosis gut microbiota generate potent activators AhR, are able impair flow. I will examine current indicating functions BBB involved development pathology.

Language: Английский

Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS): Revisiting the Meaning and Significance of the Method DOI Creative Commons
Toshiaki Taoka, Rintaro Ito, Rei Nakamichi

et al.

Magnetic Resonance in Medical Sciences, Journal Year: 2024, Volume and Issue: 23(3), P. 268 - 290

Published: Jan. 1, 2024

More than 5 years have passed since the Diffusion Tensor Image Analysis ALong Perivascular Space (DTI-ALPS) method was proposed with intention of evaluating glymphatic system. This is handy due to its noninvasiveness, provision a simple index in straightforward formula, and possibility retrospective analysis. Therefore, ALPS adopted evaluate system for many disorders studies. The purpose this review look back discuss at moment.

Language: Английский

Citations

58
The Glymphatic System in Humans: Investigations With Magnetic Resonance Imaging DOI Creative Commons
Shinji Naganawa, Toshiaki Taoka, Rintaro Ito

et al.

Investigative Radiology, Journal Year: 2023, Volume and Issue: 59(1), P. 1 - 12

Published: March 10, 2023

Abstract The concept of the glymphatic system was proposed more than a decade ago as mechanism for interstitial fluid flow and waste removal in central nervous system. function has been shown to be particularly activated during sleep. Dysfunction implicated several neurodegenerative diseases. Noninvasive vivo imaging is expected useful elucidating pathophysiology these Currently, magnetic resonance most commonly used technique evaluate humans, large number studies have reported. This review provides comprehensive overview investigations human using imaging. can divided into 3 categories, including without gadolinium-based contrast agents (GBCAs), with intrathecal administration GBCAs, intravenous GBCAs. purpose examine not only movement brain parenchyma, but also dynamics perivascular subarachnoid spaces, well parasagittal dura meningeal lymphatics. Recent research even extended include eye inner ear. serves an important update guide future directions.

Language: Английский

Citations

42
Glymphatic system dysfunction predicts amyloid deposition, neurodegeneration, and clinical progression in Alzheimer's disease DOI Creative Commons

Shu‐Yi Huang,

Ya‐Ru Zhang,

Yu Guo

et al.

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: 20(5), P. 3251 - 3269

Published: March 19, 2024

Abstract INTRODUCTION Although glymphatic function is involved in Alzheimer's disease (AD), its potential for predicting the pathological and clinical progression of AD sequential association with core biomarkers poorly understood. METHODS Whole‐brain activity was measured by diffusion tensor image analysis along perivascular space (DTI‐ALPS) participants dementia ( n = 47), mild cognitive impairment (MCI; 137), normal controls 235) from Disease Neuroimaging Initiative. RESULTS ALPS index significantly lower than MCI or controls. Lower associated faster changes amyloid positron emission tomography (PET) burden signature region interest volume, higher risk amyloid‐positive transition progression, rates amyloid‐ neurodegeneration‐related decline. Furthermore, associations decline were fully mediated PET brain atrophy. DISCUSSION Glymphatic failure may precede pathology, predicts deposition, neurodegeneration, AD. Highlights The (ALPS) reduced patients (AD) dementia, prodromal AD, preclinical predicted accelerated beta (Aβ) Aβ‐positive transition. decrease occurs before cerebrospinal fluid Aβ42 reaches positive threshold. atrophy, Aβ atrophy link

Language: Английский

Citations

42
Glymphatic System Pathology and Neuroinflammation as Two Risk Factors of Neurodegeneration DOI Creative Commons
Stanisław Szlufik,

Kamila Kopeć,

Stanisław Szleszkowski

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(3), P. 286 - 286

Published: Feb. 5, 2024

The key to the effective treatment of neurodegenerative disorders is a thorough understanding their pathomechanism. Neurodegeneration and neuroinflammation are mutually propelling brain processes. An impairment glymphatic system function in neurodegeneration contributes progression pathological question arises as how related. This review highlights direct indirect influence these two seemingly independent Protein aggregates, characteristic feature neurodegeneration, correlated with clearance neuroinflammation. Glial cells cannot be overlooked when considering neuroinflammatory Astrocytes essential for functioning play crucial role inflammatory responses central nervous system. It imperative acknowledge significance AQP4, protein that exhibits high degree polarization astrocytes AQP4 influences processes have not yet been clearly delineated. Another interesting issue gut–brain axis microbiome, which potentially impact discussed A discussion correlation between may contribute exploring pathomechanism neurodegeneration.

Language: Английский

Citations

16
Emerging non-invasive MRI techniques for glymphatic system assessment in neurodegenerative disease DOI
D. Botta,

Ioana Hutuca,

Elyas El Ghoul

et al.

Journal of Neuroradiology, Journal Year: 2025, Volume and Issue: 52(3), P. 101322 - 101322

Published: Jan. 31, 2025

Language: Английский

Citations

3
New perspectives on the glymphatic system and the relationship between glymphatic system and neurodegenerative diseases DOI Creative Commons
Yujie Sun,

Qiankun Lv,

Junyi Liu

et al.

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: 205, P. 106791 - 106791

Published: Jan. 6, 2025

Neurodegenerative diseases (ND) are characterized by the accumulation of aggregated proteins. The glymphatic system, through its rapid exchange mechanisms between cerebrospinal fluid (CSF) and interstitial (ISF), facilitates movement metabolic substances within brain, serving functions akin to those peripheral lymphatic system. This emerging waste clearance mechanism offers a novel perspective on removal pathological in ND. article elucidates recent discoveries regarding system updates relevant concepts model. It discusses potential roles ND, including Alzheimer's disease (AD), Parkinson's (PD), multiple atrophy (MSA), proposes as therapeutic target for these conditions.

Language: Английский

Citations

2
Association of Cognition and Brain Reserve in Aging and Glymphatic Function Using Diffusion Tensor Image-along the Perivascular Space (DTI-ALPS) DOI
Wen-Chiu Hsiao, Hsin‐I Chang, Shih‐Wei Hsu

et al.

Neuroscience, Journal Year: 2023, Volume and Issue: 524, P. 11 - 20

Published: April 6, 2023

Language: Английский

Citations

26
Correlation of glymphatic system abnormalities with Parkinson’s disease progression: a clinical study based on non-invasive fMRI DOI

Jing‐Cai Meng,

Mingqiang Shen,

Yanli Lu

et al.

Journal of Neurology, Journal Year: 2023, Volume and Issue: 271(1), P. 457 - 471

Published: Sept. 27, 2023

Language: Английский

Citations

24
Impaired glymphatic function as a biomarker for subjective cognitive decline: An exploratory dual cohort study DOI Creative Commons
Yuxia Li,

Luyao Wang,

Jiayi Zhong

et al.

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: 20(9), P. 6542 - 6555

Published: Aug. 6, 2024

Abstract BACKGROUND Subjective cognitive decline (SCD) has been recognized as a potential risk stage for progression to Alzheimer's disease (AD), while glymphatic dysfunction is considered an important characteristic of AD. We hypothesize that occurs during the SCD stage, aiming discover biomarkers SCD. METHODS Participants from two independent studies, Sino Longitudinal Study on Cognitive Decline (SILCODE, n = 654) and Disease Neuroimaging Initiative (ADNI, 650), representing different ethnicities stages, were included assess function using diffusion tensor image analysis along perivascular space (DTI‐ALPS). RESULTS Abnormal with ALPS index demonstrating excellent classification performance normal controls (area under receiver operating curve [AUC] SILCODE 0.816, AUC ADNI 0.797). Lower indicates higher progression, which negatively correlated Questionnaire 9 scores amyloid positron emission tomography burden. DISSCUSION Our study suggests serve biomarker Highlights Glymphatic characterized by (ALPS) becomes abnormal in subjective (SCD), earliest symptomatic manifestation preclinical (AD). The demonstrates East Asian Western cohorts. lower show clinical progression. closely associated serval scales beta

Language: Английский

Citations

10
Blood–Brain Barrier Disruption and Perivascular Spaces in Small Vessel Disease and Neurodegenerative Diseases: A Review on MRI Methods and Insights DOI Creative Commons
Paulien H.M. Voorter, Maud van Dinther, Willemijn J. Jansen

et al.

Journal of Magnetic Resonance Imaging, Journal Year: 2023, Volume and Issue: 59(2), P. 397 - 411

Published: Sept. 1, 2023

Perivascular spaces (PVS) and blood-brain barrier (BBB) disruption are two key features of cerebral small vessel disease (cSVD) neurodegenerative diseases that have been linked to cognitive impairment involved in the waste clearance system. Magnetic resonance imaging (MRI) offers possibility study these pathophysiological processes noninvasively vivo. This educational review provides an overview MRI techniques used assess PVS functionality BBB disruption. MRI-visible can be scored on structural images by either (subjectively) counting or (automatically) delineating PVS. We highlight emerging (diffusion) measure proxies perivascular fluid its movement, which may provide a more comprehensive understanding role diseases. For measurement disruption, we explain most commonly technique, dynamic contrast-enhanced (DCE) MRI, as well recently developed technique based arterial spin labeling (ASL). DCE ASL thought complementary characteristics BBB. Furthermore, describe clinical studies utilized cSVD diseases, particularly Alzheimer's (AD). These demonstrate dysfunction insight into large overlap, but also differences between AD. Overall, valuable insights mechanisms underlying potential markers for progression treatment response. LEVEL OF EVIDENCE: 3 TECHNICAL EFFICACY: Stage 2.

Language: Английский

Citations

19