Role and Diagnostic Significance of Apolipoprotein D in Selected Neurodegenerative Disorders DOI Creative Commons
Agata Kolanek,

Roman Cemaga,

Mateusz Maciejczyk

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(24), P. 2814 - 2814

Published: Dec. 14, 2024

The World Health Organization in 2021 ranked Alzheimer’s disease and other dementias as the seventh leading cause of death globally. Neurodegenerative disorders are progressive, intractable, often fatal diseases. Early diagnosis may allow patients to enjoy prolonged survival with attenuated symptomatology because early intervention. Hence, further research on finding non-invasive biomarkers neurodegenerative diseases is warranted. Apolipoprotein D (ApoD) a glycoprotein involved lipid metabolism, oxidative stress regulation, inflammation. It expressed various body fluids regions central nervous system. ApoD’s roles neuroprotection, transport, anti-inflammatory processes crucial far prevention pathologies concerned. This review aims summarize background knowledge ApoD, it covers studies indexed PubMed, Scopus, Web Science databases. discusses evidence for multifaceted ApoD mechanisms pathogenesis multiple sclerosis, disease, Parkinson’s disease. be specific, sensitive, easily obtained, cost-effective biomarker its applications diagnostic practices, treatment strategies, advancing disorders’ management.

Language: Английский

Plasma protein risk scores for mild cognitive impairment and Alzheimer's disease in the Framingham heart study DOI Creative Commons
Habbiburr Rehman, Ting Fang Alvin Ang, Qiushan Tao

et al.

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(3)

Published: March 1, 2025

Abstract INTRODUCTION It is unclear whether aggregated plasma protein risk scores (PPRSs) could be useful in predicting the risks of mild cognitive impairment (MCI) and Alzheimer's disease (AD). METHODS The Cox proportional hazard model with Least Absolute Shrinkage Selection Operator penalty was used to build PPRSs for MCI AD 1515 Framingham Heart Study Generation 2 1128 proteins measured at exam 5 (cognitively normal [CN] = 1258, 129, 128). RESULTS PPRS had a ratio (HR) 6.97 [5.34, 9.12], discriminating power (C‐index 82.52%). HR 5.74 [4.67, 7.05] 88.15%). Both were also significantly associated changes, brain atrophy, biomarkers. Proteins involved several pathways related leukocyte, chemotaxis, immunity, inflammation, cellular migration. DISCUSSION This study suggests that serve well predict developing as changes AD‐related pathogenesis brain. Highlights developed preclinical stage, MCI. loss volume, increasing level Leukocyte, migration enriched identified being PPRSs.

Language: Английский

Citations

0
Biomarkers of chronic inflammation and cognitive decline: A prospective observational study DOI Creative Commons
Bhavna A. Guduguntla, Alexi Vasbinder, Élizabeth Anderson

et al.

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring, Journal Year: 2024, Volume and Issue: 16(1)

Published: Jan. 1, 2024

Abstract We sought to determine whether the biomarkers of chronic inflammation predict cognitive decline in a prospective observational study. measured baseline serum soluble urokinase plasminogen activator receptor (suPAR) and high sensitivity C‐reactive protein (hs‐CRP) levels 282 participants University Michigan Memory Aging Project. Cognitive function was using Montreal Assessment (MoCA) Clinical Dementia Rating (CDR) scale for up five time points. SuPAR hs‐CRP were not significantly higher with mild impairment ( n = 97) or dementia 59), compared those normal 126). Overall, 14% experienced significant over study period. The change MoCA CDR scores did differ according suPAR levels. Chronic systemic inflammation, as by levels, is unlikely contribute decline.

Language: Английский

Citations

2
A genetic and proteomic comparison of key AD biomarkers across tissues DOI Creative Commons
Thomas W. Marsh, Daniel Western, Jigyasha Timsina

et al.

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: 20(9), P. 6423 - 6440

Published: July 30, 2024

Abstract INTRODUCTION Plasma has been proposed as an alternative to cerebrospinal fluid (CSF) for measuring Alzheimer's disease (AD) biomarkers, but no studies have analyzed in detail which biofluid is more informative genetics of AD. METHOD Eleven proteins associated with AD (α‐synuclein, apolipoprotein E [apoE], CLU, GFAP, GRN, NfL, NRGN, SNAP‐25, TREM2, VILIP‐1, YKL‐40) were assessed plasma ( n = 2317) and CSF 3107). Both genome‐wide association study (GWAS) analyses performed each protein, followed by functional annotation. Additional characterization biomarker included calculation correlations predictive power. RESULTS Eighteen protein quantitative train loci (pQTLs) 10 16 pQTLs 9 identified. shared some genetic loci, levels between tissues correlated weakly. better compared plasma. DISCUSSION The present results indicate that than Highlights identification novel trait both (CSF). neurodegeneration‐related (AD). Neurofilament light (NfL), triggering receptor expressed on myeloid cells 2 (TREM2), chitinase‐3‐like 1 (YKL‐40) tend show relatively strong inter‐tissue associations. A signal the APOE ) region was identified, eQTL APOC1 .

Language: Английский

Citations

1
Exerkine irisin mitigates cognitive impairment by suppressing gut-brain axis-mediated inflammation DOI Creative Commons
Hu Zhang, Jiling Liang,

Jielun Huang

et al.

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

0
Role and Diagnostic Significance of Apolipoprotein D in Selected Neurodegenerative Disorders DOI Creative Commons
Agata Kolanek,

Roman Cemaga,

Mateusz Maciejczyk

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(24), P. 2814 - 2814

Published: Dec. 14, 2024

The World Health Organization in 2021 ranked Alzheimer’s disease and other dementias as the seventh leading cause of death globally. Neurodegenerative disorders are progressive, intractable, often fatal diseases. Early diagnosis may allow patients to enjoy prolonged survival with attenuated symptomatology because early intervention. Hence, further research on finding non-invasive biomarkers neurodegenerative diseases is warranted. Apolipoprotein D (ApoD) a glycoprotein involved lipid metabolism, oxidative stress regulation, inflammation. It expressed various body fluids regions central nervous system. ApoD’s roles neuroprotection, transport, anti-inflammatory processes crucial far prevention pathologies concerned. This review aims summarize background knowledge ApoD, it covers studies indexed PubMed, Scopus, Web Science databases. discusses evidence for multifaceted ApoD mechanisms pathogenesis multiple sclerosis, disease, Parkinson’s disease. be specific, sensitive, easily obtained, cost-effective biomarker its applications diagnostic practices, treatment strategies, advancing disorders’ management.

Language: Английский

Citations

0