IL-17 A Exacerbated Neuroinflammatory and Neurodegenerative Biomarkers in Intranasal Amyloid-Beta Model of Alzheimer’s Disease

Journal of Neuroimmune Pharmacology, Journal Year: 2025, Volume and Issue: 20(1)

Published: March 31, 2025

Language: Английский

Iron Chelators and Alzheimer’s Disease Clinical Trials

Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: 100(s1), P. S243 - S249

Published: July 19, 2024

Alzheimer’s disease (AD) is a major neurodegenerative disorder impacting millions of people with cognitive impairment and affecting activities daily living. The deposition neurofibrillary tangles hyperphosphorylated tau proteins accumulation amyloid-β (Aβ) are the main pathological characteristics AD. However, actual causal process AD not yet identified. Oxidative stress occurs prior to amyloid Aβ plaque formation phosphorylation in role master antioxidant, glutathione, metal ions (e.g., iron) frontline area research. Iron overload specific brain regions associated rate decline. We have presented outcome from various interventional trials involving iron chelators intended minimize To date, however, no significant positive outcomes been reported using warrant further

Language: Английский

Oxidative Stress Monitoring Platform: A Longitudinal In vitro Multinuclear (1H/19F) MR Spectroscopic Study

Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

Language: Английский