Associations of Coffee and Tea Consumption on Neural Network Connectivity: Unveiling the Role of Genetic Factors in Alzheimer’s Disease Risk DOI Open Access
Tianqi Li, Mohammad Fili,

Parvin Mohammadiarvejeh

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(24), P. 4303 - 4303

Published: Dec. 13, 2024

Background: Coffee and tea are widely consumed beverages, but their long-term effects on cognitive function aging remain largely unexplored. Lifestyle interventions, particularly dietary habits, offer promising strategies for enhancing performance preventing decline. Methods: This study utilized data from the UK Biobank cohort (n = 12,025) to examine associations between filtered coffee, green tea, standard consumption neural network functional connectivity across seven resting-state networks. We focused networks spanning prefrontal occipital areas that linked complex behavioral functions. Linear mixed models were used assess main of coffee consumption, as well interactions with Apolipoprotein E (APOE) genetic risk—the strongest risk factor Alzheimer’s disease (AD). Results: Higher was associated increased in several networks, including Motor Execution, Sensorimotor, Fronto-Cingular, a Prefrontal + ‘What’ Pathway Network. Similarly, greater intake enhanced Extrastriate Visual Primary Networks. In contrast, higher reduced such Memory Consolidation, “What” The APOE4 genotype family history AD influenced relationship Consolidation Additionally, modified association Sensorimotor Conclusions: distinct patterns brain activity may provide insights into AD-related changes. genotype, particular, appears play significant role modulating these relationships. These findings enhance our knowledge how commonly beverages influence potentially among older adults.

Language: Английский

Cognitive Impairment and Synaptic Dysfunction in Cardiovascular Disorders: The New Frontiers of the Heart–Brain Axis DOI Creative Commons
Teresa Soda, Teresa Pasqua, Giovambattista De Sarro

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(10), P. 2387 - 2387

Published: Oct. 18, 2024

Within the central nervous system, synaptic plasticity, fundamental to processes like learning and memory, is largely driven by activity-dependent changes in strength. This plasticity often manifests as long-term potentiation (LTP) depression (LTD), which are bidirectional modulations of efficacy. Strong epidemiological experimental evidence show that heart-brain axis could be severely compromised both neurological cardiovascular disorders. Particularly, disorders, such heart failure, hypertension, obesity, diabetes insulin resistance, arrhythmias, may lead cognitive impairment, a condition known cardiogenic dementia. Herein, we review available knowledge on molecular mechanisms dementia arise describe how LTP and/or LTD induction maintenance CA1 region hippocampus metabolic syndrome, arrhythmias. We also discuss emerging endothelial dysfunction contribute directly altering hippocampal impairing synaptically induced activation nitric oxide synthase. A better understanding CV disorders impact proper function synapses will shed novel light underpinnings dementia, thereby providing new perspective for more specific pharmacological treatments.

Language: Английский

Citations

3
Advancements and challenges in mouse models of Alzheimer’s disease DOI
Zhengjiang Qian, Yanjiao Li,

Keqiang Ye

et al.

Trends in Molecular Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

3
Pros and Cons of APOE4 Homozygosity and Effects on Neuroplasticity, Malnutrition, and Infections in Early Life Adversity, Alzheimer’s Disease, and Alzheimer’s Prevention DOI
Reinaldo B. Oriá, Carr J. Smith, J. Wesson Ashford

et al.

Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: 100(s1), P. S179 - S185

Published: Aug. 2, 2024

Fortea et al.'s. (2024) recent data analysis elegantly calls attention to familial late-onset Alzheimer's disease (AD) with APOE4 homozygosity. The article by Grant reviews the factors associated AD, particularly APOE genotype and lifestyle, broad implications for prevention, both individuals lifestyles living in resource-rich countries those enduring environmental adversity poverty settings, including high exposure enteric pathogens precarious access healthcare. discusses issue of its benefits lifestyle modifications. This review highlights that bearing could constitute an evolutionary benefit coping heavy infections malnutrition early life critical formative first two years brain development. However, may be this a health concern under shifts unhealthy diets during aging, leading severe cognitive impairments increased risk AD. commentary supports discussions improving decreasing risks AD while providing further understanding modelling amidst adversity. pathophysiology should help elucidate these critical, newly appreciated pathogenic pathways developing approaches prevention management context genetic variations

Language: Английский

Citations

1
Associations of Coffee and Tea Consumption on Neural Network Connectivity: Unveiling the Role of Genetic Factors in Alzheimer’s Disease Risk DOI Open Access
Tianqi Li, Mohammad Fili,

Parvin Mohammadiarvejeh

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(24), P. 4303 - 4303

Published: Dec. 13, 2024

Background: Coffee and tea are widely consumed beverages, but their long-term effects on cognitive function aging remain largely unexplored. Lifestyle interventions, particularly dietary habits, offer promising strategies for enhancing performance preventing decline. Methods: This study utilized data from the UK Biobank cohort (n = 12,025) to examine associations between filtered coffee, green tea, standard consumption neural network functional connectivity across seven resting-state networks. We focused networks spanning prefrontal occipital areas that linked complex behavioral functions. Linear mixed models were used assess main of coffee consumption, as well interactions with Apolipoprotein E (APOE) genetic risk—the strongest risk factor Alzheimer’s disease (AD). Results: Higher was associated increased in several networks, including Motor Execution, Sensorimotor, Fronto-Cingular, a Prefrontal + ‘What’ Pathway Network. Similarly, greater intake enhanced Extrastriate Visual Primary Networks. In contrast, higher reduced such Memory Consolidation, “What” The APOE4 genotype family history AD influenced relationship Consolidation Additionally, modified association Sensorimotor Conclusions: distinct patterns brain activity may provide insights into AD-related changes. genotype, particular, appears play significant role modulating these relationships. These findings enhance our knowledge how commonly beverages influence potentially among older adults.

Language: Английский

Citations

1