Real-world safety of deucravacitinib: insights from the Food and Drug Administration Adverse Event Reporting System

International Journal of Clinical Pharmacy, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Language: Английский

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Weight-Adjusted Waist Index, Psoriasis, and All-Cause Mortality: Findings from the NHANES 2003–2006 and 2009–2014

Clinical Cosmetic and Investigational Dermatology, Journal Year: 2025, Volume and Issue: Volume 18, P. 7 - 18

Published: Jan. 1, 2025

Purpose: Psoriasis is associated with obesity, which in turn linked to increased mortality risk. Therefore, we undertook a cohort study utilizing data from the National Health and Nutrition Examination Survey (NHANES) examine impact of weight-adjusted waist index (WWI) on likelihood all-cause psoriasis individuals. Patients Methods: This utilized investigate influence WWI probability A retrospective analysis included 19,919 participants aged 18 80 years, or without psoriasis. The primary endpoint studied was all-encompassing up December 2019. interplay between analyzed through multivariable logistic regression techniques. Survival probabilities were assessed employing Kaplan-Meier curves Cox analyses. Results: Out subjects that eventually included, 522 had found be significantly positively correlated. significant correlation an incremental unit increase 63% risk patients (HR = 1.63, 95% CI 1.02– 2.61). Subgroup analyses demonstrated consistent findings within population. These suggest independent mortality. Conclusion: Our investigation revealed there strong positive US adults. For those psoriasis, managing WWI, crucial. Keywords: mortality, NHANES

Language: Английский

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Psoriasis and Psoriatic Arthritis—Associated Genes, Cytokines, and Human Leukocyte Antigens

Medicina, Journal Year: 2024, Volume and Issue: 60(5), P. 815 - 815

Published: May 16, 2024

In recent years, research has intensified in exploring the genetic basis of psoriasis (PsO) and psoriatic arthritis (PsA). Genome-wide association studies (GWASs), including tools like ImmunoChip, have significantly deepened our understanding disease mechanisms by pinpointing risk-associated loci. These efforts elucidated biological pathways involved PsO pathogenesis, particularly those related to innate immune system, antigen presentation, adaptive responses. Specific loci, such as TRAF3IP2, REL, FBXL19, been identified having a significant impact on development. Interestingly, different variants at same locus can predispose individuals either or PsA (e.g., IL23R deletion LCE3B LCE3C), with some being uniquely linked (like HLA B27 chromosome 6). This article aims summarize known new data genetics PsA, their associated genes, involvement system cytokines.

Language: Английский

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Breakthrough Psoriasis in Patients Receiving Biologicals

Psoriasis Targets and Therapy, Journal Year: 2025, Volume and Issue: Volume 15, P. 1 - 8

Published: Jan. 1, 2025

Background: Biological therapies, including TNF-alpha, IL12/23, IL17 and IL23 antagonists, adequately control a very high number of patients with moderate-to-severe psoriasis an excellent long-term safety profile. However, on occasion, biological therapy stabilized disease or complete remission report episodes sudden breakthrough psoriasis. Aim: To study prospectively in monocentric tertiary setting, the clinical characteristics presenting although completely (PASI 90– 100) under therapy. Materials Methods: Psoriasis treated by therapies achieving PASI 100 for at least 6 months were invited to enter follow-up 5 years. The features described as well rescue outcomes. Results: From total cohort 1121 receiving biologicals, 985 responded inclusion criteria. After years, 10/882 cases (1,13%) identified. Two induced Köbner phenomenon 8 severe psychological stress. Rescue included topical potent corticosteroids additional injections biological. recovered spontaneously when stressful event was resolved. In none cases, there consistency between next scheduled injection, nor duration exposure treatment. No class agent could be systematically incriminated. Conclusion: Breakthrough is exceptional among using either triggered pathogenesis events linked stress- Köbner-related immunomodulation, permitting lesions appear. Keywords: psoriasis, IL17, IL23, phenomenon, stress

Language: Английский

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Indikation zur Systemtherapie bei Psoriasis: Kommentierte Checkliste für die Praxis

JDDG Journal der Deutschen Dermatologischen Gesellschaft, Journal Year: 2025, Volume and Issue: 23(2), P. 281 - 283

Published: Feb. 1, 2025

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Enrichment analysis of loci associated with psoriasis susceptibility identified in genome-wide association studies

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: March 15, 2025

Language: Английский

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Pharmacotherapeutic management of psoriatic disease: addressing psoriatic Arthritis and cutaneous manifestations

Expert Opinion on Pharmacotherapy, Journal Year: 2024, Volume and Issue: 25(16), P. 2203 - 2212

Published: Oct. 18, 2024

Introduction Psoriasis and psoriatic arthritis (PsA) are interrelated autoimmune conditions sharing similar genetic immunological pathways. PsA often develops within ten years of psoriasis onset, though it may precede cutaneous symptoms in some patients. Effective management these requires a multidisciplinary approach to address skin, bone, joint, vascular manifestations.

Language: Английский

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Health benefits of exercise and dietary interventions for patients with psoriasis – a literature review

Journal of Education Health and Sport, Journal Year: 2024, Volume and Issue: 73, P. 51552 - 51552

Published: June 14, 2024

Introduction: Psoriasis is a prevalent chronic inflammatory systemic disease that can manifest in variety of clinical manifestations. was thought to only affect the skin. Recent findings from dermatologic, rheumatologic, and cardiologic research indicate it disease, henceforth referred as psoriatic disease. Purpose work: Collecting information on benefits physical activity diet modifications patients with psoriasis aspects such metabolic syndrome, cardiovascular risk, mental health, general well-being. Summary: affects many areas life. Physical improves body weight, risk psoriasis. Engaging may reduce probability developing also ameliorate its course. The Mediterranean diet, ketogenic probiotics, alcohol withdrawal alleviate course It noteworthy mention potential limitations arise context this including embarrassment resulting skin lesions joint discomfort arthritis. Sports training ought be customized for each patient, taking into account their preferences.

Language: Английский

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Especialidades médicas - Volume 1

Editora Pascal LTDA eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 9, 2024

Este livro aborda de forma clara e didática as principais especialidades médicas, oferecendo conteúdo atualizado para profissionais estudantes. Explora áreas como cardiologia, neurologia cirurgia, com ênfase na prática clínica nos desafios atuais da medicina. Os capítulos combinam teoria casos reais, proporcionando uma visão ampla prática. Essencial quem deseja aprofundar seus conhecimentos se preparar os profissão médica.

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