“Bridging Microbiomes: Exploring Oral and Gut Microbiomes in Autoimmune Thyroid Diseases- New Insights and Therapeutic Frontiers DOI Creative Commons

Daliya Abubakar,

Hala Abdullahi,

Ibrahim Ibrahim

et al.

Gut Microbes Reports, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 20

Published: Jan. 15, 2025

Autoimmune thyroid diseases (AITDs) are the most common organ-specific autoimmune disorders characterized by dysfunction and immune system deficiencies. In recent decades, role of microbiome in has gained increasing attention, with emerging research linking gut alterations to development AITDs. This review summarizes current knowledge on relationship between AITDs microbiome. Additionally, it emphasizes oral AITDs, an area often overlooked research. Beyond microbiome, virome mycobiome have been recognized as critical but underexplored components human potentially contributing dysregulation pathogenesis The also explores modulating for managing including diet adjustment, potential use probiotics, postbiotics, symbiotics, even fecal microbiota transplantation (FMT) restore a balanced that may positively influence and, extension, course thoroughly intricate gut, microbiomes, paving way precision medicine applications Examining microbiota-thyroid interactions highlights targeted, personalized treatments novel therapeutic therapies, guiding future strategies more effective precisely tailored AITD management approaches.

Language: Английский

Magnesium and Longevity DOI Creative Commons
Patrick Chambers

Published: Nov. 7, 2024

Magnesium (Mg) is not prominent among the list of well known anti-aging agents. Yet signs and symptoms aging mimic those Mg deficiency. required for over 800 enzymatic reactions (as 2022). This review does correlate status with clinical data on agents linked to longevity. The approach physiologic highlights specific dependent by these longevity biomarkers. Many share common pathways extend healthspan. a cofactor in synthesis vitamin D melatonin activation six eight B vitamins. It all CYP450 enzymes. directly responsible appropriate methylation proteins DNA, which control epigenome. MTHFR (methylenetetrahydrofolate reductase) 677T allele that compromises present majority Americans. Aberrant predicts severity Covid-19 its persistence into long Covid. silent benefactor may indirectly link agents, but only if viewed context calcium (Ca), i.e., Ca:Mg. Both compete same receptor. To fully exploit sufficient required. pertinent physiology presented.

Language: Английский

Citations

5
“Bridging Microbiomes: Exploring Oral and Gut Microbiomes in Autoimmune Thyroid Diseases- New Insights and Therapeutic Frontiers DOI Creative Commons

Daliya Abubakar,

Hala Abdullahi,

Ibrahim Ibrahim

et al.

Gut Microbes Reports, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 20

Published: Jan. 15, 2025

Autoimmune thyroid diseases (AITDs) are the most common organ-specific autoimmune disorders characterized by dysfunction and immune system deficiencies. In recent decades, role of microbiome in has gained increasing attention, with emerging research linking gut alterations to development AITDs. This review summarizes current knowledge on relationship between AITDs microbiome. Additionally, it emphasizes oral AITDs, an area often overlooked research. Beyond microbiome, virome mycobiome have been recognized as critical but underexplored components human potentially contributing dysregulation pathogenesis The also explores modulating for managing including diet adjustment, potential use probiotics, postbiotics, symbiotics, even fecal microbiota transplantation (FMT) restore a balanced that may positively influence and, extension, course thoroughly intricate gut, microbiomes, paving way precision medicine applications Examining microbiota-thyroid interactions highlights targeted, personalized treatments novel therapeutic therapies, guiding future strategies more effective precisely tailored AITD management approaches.

Language: Английский

Citations

0