Phytochemistry and anticholinesterase activities of eight Marrubium taxa

Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: Jan. 6, 2025

Marrubium (Lamiaceae) species are traditionally used for their expectorant and antipyretic effects. However, limited research has been conducted on the phytochemical bioactivity of most species, except M. vulgare L. utilized in both pharmaceutical food industries. In present study, phenolic profiles marrubiin contents eight taxa, four which endemic to Türkiye, were investigated. Methanolic extracts prepared using an ultrasonic bath, while acidic extractions performed following instructions outlined European Pharmacopoeia. The samples also evaluated acetylcholinesterase (AChE) butyrylcholinesterase (BChE) activities. results indicated that all taxa contained different amounts forsythoside B (30–183 mg/100 g dw) verbascoside (124–287 dw). Elevated levels tiliroside detected, particularly within taxa. some did not contain marrubiin, marker compound genus. highest AChE BChE inhibitory activities observed peregrinum. Verbascoside candidate molecules as compounds genus Marrubium. This study provides a detailed chemical composition one-fifth world's first time. anisodon show potential industry.

Language: Английский

Bakuchiol impact on ageing and longevity: Insights from Caenorhabditis elegans studies

Annals of Phytomedicine An International Journal, Journal Year: 2024, Volume and Issue: 13(1)

Published: July 1, 2024

The efficacy of any herbal medication hinges on delivering adequate levels plant extract from the therapeutically active phytomolecules.Bakuchiol (BAK), a monoterpenoid derived Psoralea corylifolia with its relevance in cultural and traditional Chinese medicine.Owing to unique aspects, this molecule has been demonstrated improve lifespan antiageing fewer side effects than synthetic alternatives easier use.BAK offers enormous benefits for skin rejuvenation; it acts as natural retinol alternative, enhancing collagen formation, maintaining suppleness minimizing wrinkles.Furthermore, research conducted model organism Caenorhabditis elegans, nematode prominently one primo systems ageing revealed significant elevation acetylcholine (Ach) transmission, reduction reactive oxygen species (ROS) extension lifespan.Research into longevity using phytomolecules is an intriguing area that explores potential leverageing compounds plants prolong organism.C. elegans provided valuable insights intricate molecular genetic mechanisms underlying process.The emerging complex relationship between bakuchiol C. controlling development by gently altering genes, particularly those within mTOR insulin/IGF-1 signaling pathways, BAK bestowed worms ability extended promoting cellular renewal.The current study sheds light alter pathways linked suggest activate proteins strongly associated lifespans better health.

Language: Английский