Chemical Biology & Drug Design,
Journal Year:
2023,
Volume and Issue:
103(1)
Published: Dec. 13, 2023
Abstract
As
an
expert
in
the
field
of
drug
design
and
discovery,
I
tried,
this
up‐to‐date
perspective
or
commentary
article,
to
recap
shed
light
on
previous
latest
revolutionary
strategies
employed
medicinal
therapeutic
chemistry
target
principal
viral
weapon
used
by
virulent
RNA
viruses
(e.g.,
severe
acute
respiratory
syndrome
coronavirus
2
“SARS‐CoV‐2”)
infect
humans
spread
infections,
genomic
strands.
These
act
taking
advantage
weakness
points
attractive
bioweapon
disable
attack
it
(itself),
accordingly
stop
entire
reproduction,
effectively
end
microbial
infections
such
as
disease
2019
(COVID‐19).
The
generation
respective
slightly
falsely‐weaved
strands,
either
endogenously
exogenously,
is
key
for
designing
most
these
approaches.
Trials,
Journal Year:
2025,
Volume and Issue:
26(1)
Published: March 24, 2025
Pandemics
have
increasingly
become
more
frequent.
Globally,
between
1970
and
2016,
a
total
of
over
1770
disease
outbreaks
38
known
two
unknown
causes
were
reported.
Vaccines
are
key
medical
countermeasure
for
most
these
outbreaks,
however,
developed
tested
outside
Sub-Saharan
Africa.
There
is
underrepresentation
Africa
in
vaccine
clinical
trials.
This
attributed
to
poor
visibility
existing
sites,
limited
infrastructure
unpredictable
regulatory
timelines,
lack
capacity
basic
science
research.
We
draw
on
lessons
from
an
Ebola
outbreak
Uganda
suggest
factors
establishing
trial
site
low
resource
setting.
The
trained
staff,
availability
adaptation
generic
protocols,
establishment
cold
chain
storage
facilities,
south-south
collaborations,
in-country
stewardship,
close
collaboration
with
ethical
bodies.
African
institutions
could
capitalise
the
epidemics
accompanying
responses
build
trials
position
themselves
take
part
global
Journal of Biomolecular Structure and Dynamics,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 19
Published: Feb. 6, 2024
The
lack
of
effective
medicines
or
vaccines,
combined
with
climate
change
and
other
environmental
factors,
annually
subjects
a
significant
proportion
the
world's
inhabitants
to
risk
dengue
virus
(DENV)
infection.
These
conditions
increase
likelihood
exposure
mosquito-borne
diseases
such
as
fever.
Hence,
many
research
approaches
tend
develop
efficient
vaccine
candidates
against
virus.
Therefore,
we
used
immunoinformatics
bioinformatics
design
construction
for
developing
candidate
serotypes.
In
this
study,
in
silico
structure,
containing
non-structural
protein
1
region
(NS1)
(consensus
epitope),
envelope
domain
III
(EDIII)
structural
part
construction,
bc-loop
II
(EDII)
neutralizing
protected
epitope,
were
employed.
We
utilized
tools
enhance
immunogenicity
effectiveness
candidates.
Evaluations
included
refining
validating
physicochemical
characteristics,
B
T-cell
epitopes,
homology
modeling,
three-dimensional
structure
assess
designed
vaccine's
quality.
results
tertiary
prediction
validation
revealed
high-quality
modeling
all
constructs.
Additionally,
instructed
model
demonstrated
stability
throughout
molecular
dynamics
simulation.
immune
simulation
suggested
that
titers
IgG
IgM
could
be
raised
desirable
values
following
injection
into
vivo
models.
It
can
concluded
construct
effectively
induce
humoral
cellular
immunity
proposed
four
Current Pharmaceutical Analysis,
Journal Year:
2024,
Volume and Issue:
20(4), P. 231 - 240
Published: April 1, 2024
Background:
The
screening
of
active
ingredients
in
traditional
Chinese
medicine
is
an
important
task
the
modernization
medicine,
and
commonly
used
analytical
means
past
were
mainly
to
screen
extracts
through
pharmacological
experiments,
but
method
has
major
defects.
target
fishing
strategy
provides
a
new
idea
for
ingredients,
it
rapidly
become
hot
research
direction,
there
are
many
methods
that
need
be
summarized
aggregated.
Objective:
It
aims
provide
readers
with
understanding
achievements,
developments,
dilemmas
techniques
over
few
years
ideas
subsequent
research.
Methods:
Research
articles
recent
using
as
entry
point
basis
summarize
types
literature
based
on
their
principles
characteristics
discuss
advantages
disadvantages
each
method.
Conclusion:
This
paper
summarizes
classification
development
such
ultrafiltration,
equilibrium
dialysis,
cell
membrane
chromatography,
immobilization
molecules
describes
these
methods.
applications
summarized,
problems
solutions
discussed.
Expert Review of Anti-infective Therapy,
Journal Year:
2024,
Volume and Issue:
22(7), P. 547 - 555
Published: March 8, 2024
Background
This
study
aims
to
compare
the
effectiveness
and
safety
of
nirmatrelvir/ritonavir
(Paxlovid)
sotrovimab
for
coronavirus
disease
2019
(COVID-19).
Expert Review of Anti-infective Therapy,
Journal Year:
2024,
Volume and Issue:
22(7), P. 569 - 577
Published: June 1, 2024
Since
the
end
of
2022,
Azvudine
was
widely
used
to
treat
hospitalized
coronavirus
disease
2019
(COVID-19)
patients
in
China.
However,
data
on
real-world
effectiveness
against
severe
outcomes
and
post-COVID-19-conditions
(PCC)
among
infected
by
acute
respiratory
syndrome
2
(SARS-CoV-2)
Omicron
variants
limited.
This
study
evaluates
COVID-19
during
a
SARS-CoV-2
BA.5
dominance
period.
Expert Review of Anti-infective Therapy,
Journal Year:
2024,
Volume and Issue:
22(6), P. 487 - 493
Published: Jan. 24, 2024
Background
To
evaluate
the
opinions
of
healthcare
workers
regarding
drug
therapy
problems
linked
to
anti-infective
medicines
used
for
treatment
COVID-19
infection
in
Pakistan.
Expert Review of Anti-infective Therapy,
Journal Year:
2024,
Volume and Issue:
22(11), P. 977 - 985
Published: May 4, 2024
Objectives
This
study
assessed
the
effectiveness
of
oral
antiviral
agents
nirmatrelvir
–
ritonavir
(NMV-r)
and
molnupiravir
(MOV)
for
treating
mild-to-moderate
coronavirus
disease
2019
(COVID-19)
in
patients
with
COPD.
