Predicting immune status and gene mutations in stomach adenocarcinoma patients based on inflammatory response-related prognostic features DOI Creative Commons
Huanjun Li,

Jingtang Chen,

Zhiliang Chen

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 9, 2025

Stomach adenocarcinoma (STAD) is an aggressive malignant tumor. Herein, we characterized the prognosis based on inflammatory response-related features and evaluated their potential impact survival immune status of STAD patients. Inflammation-related genes obtained from public databases were used to analyze response scores samples. The differentially expressed (DEGs) between adjacent gastric tissue then analyzed using "limma" package. Genes associated with intersection inflammation-related DEGs. key screened by last absolute shrinkage selection operator (LASSO) Cox stepwise regression analyses construct prognostic models nomograms. tumor dysfunction exclusion (TIDE) algorithm was assess differences in immunotherapy high- low-risk groups explore gene mutation signatures R software maftools In addition, GSEA predict pathway characteristics different subgroups. Finally, scratch transwell assays performed role SERPINE1 cells. We found that a high-inflammatory group poor 14 DEGs out 126 identified be patients, nomograms constructed subsequently (SLC7A1, CD82, ROS1 SLC7A2) demonstrated good predictive performance terms STAD. Patients high-risk had higher StromalScore TIDE scores. It also patients may have burden. Enrichment analysis revealed significant enrichment epithelial-mesenchymal transition, angiogenesis KRAS pathways group. In-vitro experiments showed down-regulation attenuated migratory invasive abilities AGS This study provides new insights into prediction for perspective response.

Language: Английский

The genus Valeriana L.: ethnopharmacology, phytochemistry and biological activities—an updated review DOI Creative Commons

Cansel Çelik,

Hasan Kırmızıbekmez

Phytochemistry Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Abstract The genus Valeriana L. is a large with its 436 accepted species distributed all over the world. Some members of have been utilized in different folk medicines to cure many diseases especially anxiety, sleep disorders and epilepsy since remote times. Pharmacological studies on extracts prepared mostly from below ground parts some mainly V. officinalis , jatamansi V . amurensis revealed their diverse bioactivities including, anxiolytic, antidepressant, anticonvulsant, anti-inflammatory, cytotoxic, anticancer activities. Many secondary metabolites isolated characterized several that belong iridoid, sesquiterpene, lignan, flavonoid chemical classes. Bioactivity iridoids, sesquiterpenes, lignans derived these possess significant biological activities such as anticancer, neuroprotective, antiviral This comprehensive review aims provide an overview traditional use phytochemical composition well very recent species. Recent vitro, vivo, clinical are reviewed discussed, particularly focusing anti-viral compounds Among metabolites, seem be responsible for pharmacological extracts. Although promising results were reported vitro studies, it essential perform vivo even order discover new potential drug leads this genus.

Language: Английский

Citations

0
Predicting immune status and gene mutations in stomach adenocarcinoma patients based on inflammatory response-related prognostic features DOI Creative Commons
Huanjun Li,

Jingtang Chen,

Zhiliang Chen

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 9, 2025

Stomach adenocarcinoma (STAD) is an aggressive malignant tumor. Herein, we characterized the prognosis based on inflammatory response-related features and evaluated their potential impact survival immune status of STAD patients. Inflammation-related genes obtained from public databases were used to analyze response scores samples. The differentially expressed (DEGs) between adjacent gastric tissue then analyzed using "limma" package. Genes associated with intersection inflammation-related DEGs. key screened by last absolute shrinkage selection operator (LASSO) Cox stepwise regression analyses construct prognostic models nomograms. tumor dysfunction exclusion (TIDE) algorithm was assess differences in immunotherapy high- low-risk groups explore gene mutation signatures R software maftools In addition, GSEA predict pathway characteristics different subgroups. Finally, scratch transwell assays performed role SERPINE1 cells. We found that a high-inflammatory group poor 14 DEGs out 126 identified be patients, nomograms constructed subsequently (SLC7A1, CD82, ROS1 SLC7A2) demonstrated good predictive performance terms STAD. Patients high-risk had higher StromalScore TIDE scores. It also patients may have burden. Enrichment analysis revealed significant enrichment epithelial-mesenchymal transition, angiogenesis KRAS pathways group. In-vitro experiments showed down-regulation attenuated migratory invasive abilities AGS This study provides new insights into prediction for perspective response.

Language: Английский

Citations

0