Exploring Potential Therapeutic Applications of Tazarotene: Gene Regulation Mechanisms and Effects on Melanoma Cell Growth DOI Creative Commons
Chun‐Hua Wang, Lu‐Kai Wang, Fu‐Ming Tsai

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(4), P. 237 - 237

Published: March 28, 2025

Tazarotene, a retinoid derivative, is widely used in treating skin conditions such as psoriasis and acne. Recent studies have demonstrated its potential promising therapeutic agent for melanoma situ. Its primary mechanism of action involves the selective activation retinoic acid receptors (RAR-β RAR-γ), which play important roles regulating cell growth, differentiation, apoptosis. By activating these receptors, tazarotene influences expression several downstream inducible genes, tazarotene-induced gene-1 (TIG1), TIG2, TIG3. These genes crucial proliferation, invasiveness, immune responses tumor microenvironment. This review aims to provide comprehensive overview current status derivatives—particularly tazarotene—in treatment latest research regarding their molecular mechanisms. We will explore how suppresses growth through gene regulation mechanisms discuss role within Additionally, we assess advantages challenges using topical future clinical applications. contribute wider understanding tazarotene’s antitumor mechanisms, providing solid theoretical foundation option

Language: Английский

Exploring Potential Therapeutic Applications of Tazarotene: Gene Regulation Mechanisms and Effects on Melanoma Cell Growth DOI Creative Commons
Chun‐Hua Wang, Lu‐Kai Wang, Fu‐Ming Tsai

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(4), P. 237 - 237

Published: March 28, 2025

Tazarotene, a retinoid derivative, is widely used in treating skin conditions such as psoriasis and acne. Recent studies have demonstrated its potential promising therapeutic agent for melanoma situ. Its primary mechanism of action involves the selective activation retinoic acid receptors (RAR-β RAR-γ), which play important roles regulating cell growth, differentiation, apoptosis. By activating these receptors, tazarotene influences expression several downstream inducible genes, tazarotene-induced gene-1 (TIG1), TIG2, TIG3. These genes crucial proliferation, invasiveness, immune responses tumor microenvironment. This review aims to provide comprehensive overview current status derivatives—particularly tazarotene—in treatment latest research regarding their molecular mechanisms. We will explore how suppresses growth through gene regulation mechanisms discuss role within Additionally, we assess advantages challenges using topical future clinical applications. contribute wider understanding tazarotene’s antitumor mechanisms, providing solid theoretical foundation option

Language: Английский

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