TRIM36 serves as a prognostic indicator linked to immune infiltration in KIRC
Jikai Zhang,
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B.S. Zou,
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Yun-Feng Geng
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et al.
Heliyon,
Journal Year:
2025,
Volume and Issue:
11(4), P. e42540 - e42540
Published: Feb. 1, 2025
Renal
cell
carcinoma
(RCC)
represents
approximately
85%
of
all
renal
malignant
tumors,
with
kidney
clear
(KIRC)
being
the
most
typical
subtype.
The
tripartite
motif
(TRIM)
family
is
involved
in
cancer
initiation,
progression,
and
therapy
resistance.
While
TRIM36
has
exhibited
anti-tumor
effects
various
cancers,
its
relationship
KIRC
remains
unclear.
In
our
research,
we
studied
between
KIRC.
Through
a
combination
bioinformatic
analyses
validation
experiments,
noted
rise
expression
KIRC,
upregulation
associated
poorer
prognosis
Also,
findings
from
wound
healing
assays
transwell
migration
showed
that
promotes
proliferation
cells.
To
understand
underlying
mechanisms,
screened
relevant
genes
conducted
enrichment
analysis.
We
identified
may
interact
5
hub
involve
cycle
division
processes
Additionally,
through
immune
infiltration
analysis,
found
6
tumor-infiltrating
lymphocytes
(TILs)
inhibitors.
summary,
research
identifies
as
promising
biomarker
comprehensively
explores
promoting
effect
on
Language: Английский
Proteomics and lipidomics of human umbilical cord mesenchymal stem cells exposed to ionizing radiation
European journal of medical research,
Journal Year:
2025,
Volume and Issue:
30(1)
Published: April 28, 2025
Mesenchymal
stem
cell
(MSC)-based
therapies
exhibit
beneficial
effects
on
various
forms
of
tissue
damage,
including
ionizing
radiation-induced
lesions.
However,
whether
radiation
affects
the
functions
human
umbilical
cord
mesenchymal
cells
(hucMSCs)
remains
unclear.
This
study
aimed
to
investigate
effect
and
possible
mechanisms
proliferation
differentiation
hucMSCs.
The
hucMSCs
were
divided
into
1
Gy
group
(exposure
a
single
dose
(1
Gy)
X-ray
Gy/min)
for
14
days)
control
(without
treatment)
group.
proliferation,
apoptosis,
adipogenic
osteogenic
abilities
in
two
groups
evaluated.
Moreover,
lipidomics
proteomics
analyses
conducted
explore
crucial
lipids
proteins
by
which
affected
In
addition,
BYSL
radiation-treated
explore,
as
well
involved
potential
mechanisms.
treatment
inhibited
promoted
decreased
Key
lipids,
such
triglyceride
(TG)
phosphatidylcholine
(PC),
hub
(BYSL,
MRTO4,
RRP9)
exhibited
significant
differences
between
BYSL,
RRP9
significantly
correlated
with
TG
PC.
overexpression
evidently
hucMSCs,
protein
expression
levels
p-GSK-3β/GSK-3β
β-catenin,
while
suppressed
apoptosis.
GSK-3β
inhibitor
(1-Az)
reversed
p-GSK-3β/GSK-3β,
β-catenin
Our
findings
reveal
that
are
radiation,
may
be
associated
changes
key
(TG
PC)
RRP9).
Furthermore,
promotes
via
GSK-3β/β-catenin
pathway.
These
help
explain
response
have
clinical
implications
improving
outcomes
MSC-based
after
radiotherapy.
Language: Английский
Insights into the Gene Expression Profile of Classical Hodgkin Lymphoma: A Study towards Discovery of Novel Therapeutic Targets
Molecules,
Journal Year:
2024,
Volume and Issue:
29(15), P. 3476 - 3476
Published: July 25, 2024
Classical
Hodgkin
lymphoma
(cHL)
is
a
common
B-cell
cancer
and
significant
health
concern,
especially
in
Western
Asian
countries.
Despite
the
effectiveness
of
chemotherapy,
many
relapse
cases
are
being
reported,
highlighting
need
for
improved
treatments.
This
study
aimed
to
address
this
issue
by
discovering
biomarkers
through
analysis
gene
expression
data
specific
cHL.
Additionally,
potential
anticancer
inhibitors
were
explored
target
discovered
biomarkers.
proceeded
retrieving
microarray
from
cHL
patients,
which
was
then
analyzed
identify
differentially
expressed
genes
(DEGs).
Functional
network
annotation
upregulated
revealed
active
involvement
matrix
metallopeptidase
12
(MMP12)
C-C
motif
ligand
22
(CCL22)
progression
mentioned
found
be
actively
involved
cancer-related
pathways,
i.e.,
oxidative
phosphorylation,
complement
pathway,
myc_targets_v1
TNFA
signaling
via
NFKB,
etc.,
showed
strong
associations
with
other
known
promote
progression.
MMP12,
topping
list
logFC
value
+6.6378,
selected
inhibition
using
docking
simulation
strategies.
The
compounds
docked
into
site
MMP12
molecular
structure,
revealing
binding
scores
-7.7
kcal/mol
-7.6
BDC_24037121
BDC_27854277,
respectively.
Simulation
studies
complexes
further
supported
effective
ligands,
yielding
MMGBSA
MMPBSA
-78.08
-82.05
MMP12-BDC_24037121
-48.79
-49.67
MMP12-BDC_27854277,
Our
findings
highlight
role
cHL,
effectively
inhibiting
its
function
potentially
halting
advancement
Further
exploration
downregulated
warranted,
as
associated
may
play
CCL22
should
considered
investigation
due
Language: Английский